Ben Deverman Lab Materials

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Title	Authors	Publication
A High-Efficiency AAV for Endothelial Cell Transduction Throughout the Central Nervous System.	Krolak T, Chan KY, Kaplan L, Huang Q, Wu J, Zheng Q, Kozareva V, Beddow T, Tobey IG, Pacouret S, Chen AT, Chan YA, Ryvkin D, Gu C, Deverman BE	Nat Cardiovasc Res. 2022 Apr;1(4):389-400. doi: 10.1038/s44161-022-00046-4. Epub 2022 Apr 13.
An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery.	Huang Q, Chan KY, Wu J, Botticello-Romero NR, Zheng Q, Lou S, Keyes C, Svanbergsson A, Johnston J, Mills A, Lin CY, Brauer PP, Clouse G, Pacouret S, Harvey JW, Beddow T, Hurley JK, Tobey IG, Powell M, Chen AT, Barry AJ, Eid FE, Chan YA, Deverman BE	Science. 2024 Jun 14;384(6701):1220-1227. doi: 10.1126/science.adm8386. Epub 2024 May 16.
Systematic multi-trait AAV capsid engineering for efficient gene delivery.	Eid FE, Chen AT, Chan KY, Huang Q, Zheng Q, Tobey IG, Pacouret S, Brauer PP, Keyes C, Powell M, Johnston J, Zhao B, Lage K, Tarantal AF, Chan YA, Deverman BE	Nat Commun. 2024 Aug 4;15(1):6602. doi: 10.1038/s41467-024-50555-y.
Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier.	Huang Q, Chen AT, Chan KY, Sorensen H, Barry AJ, Azari B, Zheng Q, Beddow T, Zhao B, Tobey IG, Moncada-Reid C, Eid FE, Walkey CJ, Ljungberg MC, Lagor WR, Heaney JD, Chan YA, Deverman BE	PLoS Biol. 2023 Jul 19;21(7):e3002112. doi: 10.1371/journal.pbio.3002112. eCollection 2023 Jul.

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	ID	Plasmid	Gene/Insert	Vector Type	Publication
100.447.615902.183749	183749	kiCAP-AAV-BI30	AAV9 modified with 7mer insertion between amino acids 588 and 589 of VP1	AAV	A High-Efficiency AAV for Endothelial Cell Transduction Throughout the Central Nervous System. Nat Cardiovasc Res. 2022 Apr;1(4):389-400. doi: 10.1038/s44161-022-00046-4. Epub 2022 Apr 13.
50.18.147209.183775	183775	pAAV-CAG-SV40NLSf-GFP-3xmiR122-WPRE-HGHpA	NLS-GFP	AAV	A High-Efficiency AAV for Endothelial Cell Transduction Throughout the Central Nervous System. Nat Cardiovasc Res. 2022 Apr;1(4):389-400. doi: 10.1038/s44161-022-00046-4. Epub 2022 Apr 13.
50.15.642521.183776	183776	pAAV-CAG-Cre-3xmiR122-WPRE-HGHpA	Cre	AAV	A High-Efficiency AAV for Endothelial Cell Transduction Throughout the Central Nervous System. Nat Cardiovasc Res. 2022 Apr;1(4):389-400. doi: 10.1038/s44161-022-00046-4. Epub 2022 Apr 13.
20.91.438943.218796	218796	kiCAP-AAV-BI-hTFR1	AAV Rep-Cap BI-hTFR1	Mammalian Expression	An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery. Science. 2024 Jun 14;384(6701):1220-1227. doi: 10.1126/science.adm8386. Epub 2024 May 16.
	203532	iCAP-BI-28-KanR	AAV-BI28 Cap	Mammalian Expression, AAV	Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier. PLoS Biol. 2023 Jul 19;21(7):e3002112. doi: 10.1371/journal.pbio.3002112. eCollection 2023 Jul.
	203533	iCAP-BI-48-KanR	AAV-BI48 Cap	Mammalian Expression, AAV	Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier. PLoS Biol. 2023 Jul 19;21(7):e3002112. doi: 10.1371/journal.pbio.3002112. eCollection 2023 Jul.
	203534	iCAP-BI-49-KanR	AAV-BI49 Cap	Mammalian Expression, AAV	Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier. PLoS Biol. 2023 Jul 19;21(7):e3002112. doi: 10.1371/journal.pbio.3002112. eCollection 2023 Jul.
	203535	iCAP-BI-62-KanR	AAV-BI62 Cap	Mammalian Expression, AAV	Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier. PLoS Biol. 2023 Jul 19;21(7):e3002112. doi: 10.1371/journal.pbio.3002112. eCollection 2023 Jul.
	203536	iCAP-BI-65-KanR	AAV-BI65 Cap	Mammalian Expression, AAV	Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier. PLoS Biol. 2023 Jul 19;21(7):e3002112. doi: 10.1371/journal.pbio.3002112. eCollection 2023 Jul.
	203539	AAV-CAG-SV40NLSf-mScarlet-P2A-hLuc-WPRE	NLS-mScarlet-2A-mScarlet	Mammalian Expression, AAV	Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier. PLoS Biol. 2023 Jul 19;21(7):e3002112. doi: 10.1371/journal.pbio.3002112. eCollection 2023 Jul.