...bias observed in young macaques and vascular bias in mature marmosets. CAP-Mac also robustly expressed...primary cells Monomeric StayGold variants AAV.CAP-Mac for systemic gene transfer in primate brains Endothelial-specific...rs.3.rs-3188559/v1.  Neurogenetic alchemy: CAP-Mac unleashes the secrets of primate brains with brilliance...adeno-associated virus (AAV) vector named AAV.CAP-Mac for non-invasive systemic gene delivery in non-human...2023). They found the best-performing variant, CAP-Mac, was effective at breaching the blood-brain barrier...to identification and characterization of AAV.CAP-Mac. Image reproduced from Chuapoco, Flytzanis, Goeden...2023, under CC-BY license.   Find the AAV.CAP-Mac plasmid here!   Chuapoco, M.R., Flytzanis, N.C.,...

... our paper, “Synthetic recombinase-based state machines in living cells” (1), into a more straight-forward...our engineered devices, recombinase-based state machines for your own experimental needs. For more context...the paper. Why might one be interested in state machine technology? Biological research has produced a ...timing of these factors. Recombinase-based state machines (RSMs), which take on a particular DNA-sequence...terminators, etc) are composed. Fear not – the state machine design space is highly degenerate and often times...Roquet et al., Synthetic recombinase-based state machines in living cells. Science. 353, aad8559 (2016).... recombinase-based state machines...

...ab1 chromatogram file 4Peaks (Mac) SnapGene Viewer (Mac/PC) FinchTV(Mac/PC) Chromas (PC) 2. You should...

...web and desktop version that works with Windows, Mac, and Linux operating systems.  Zotero  Zotero is ...is a desktop based program that’s compatible with Mac, Windows, and Linux.  Mendeley and Zotero have a ...

...is magnetic bead-activated cell sorting, or MACS. But MACS usually only allows for sorting based on a ...achieves greater purity of your sorted cell sample than MACS. An effective strategy to sort out your cells of...

...This post was contributed by guest blogger Sean Mac Fhearraigh, co-founder of www.assaygenie.com. No ... cycle.  Many thanks to our Guest Blogger, Sean Mac Fhearraigh! Seán was a PhD student at University...

...al, 2023 AAV.CAP-Mac CNS: neurons (rats, infant green monkey, rhesus macaque); vasculature (adult...Old World monkeys AAV.CAP-Mac is largely neurotropic in infant rhesus macaques and green monkeys (Chuapoco...caption adapted from Campos et al., 2023. AAV.CAP-Mac is a systemic capsid, developed and deposited by ...selected from a library screened in marmosets. AAV.CAP-Mac effectively transduces vasculature in adult marmosets...astrocytes (Chuapoco et al., 2023). Additionally, AAV.CAP-Mac has a lower transduction rate than AAV9 in the liver... rhesus macaques (Chen et al., 2022). AAV.MaCPNS2 is slightly more effective than AAV.MaCPNS1 at transducing...rats); CNS neurons (infant rhesus macaques) Mice, rats, rhesus macaques No (mechanism unknown)   Chen...

...source and available for desktop use for Windows, Mac OS X, and Linux. Inkscape is versatile and has a ...

...This guest blog post was contributed by Seán Mac Fhearraigh, PhD, of www.phdadvice.com. I sold out, well...death assays. You can find Seán on twitter @Macfhearraigh.    Read more posts about Scientific Career ...

... Pubmed PMID: 3325793 Schumacher MA (2012) Bacterial plasmid partition machinery: a minimalist approach...origin of replication and the replication control machinery (Need a refresher on the Origin of Replication...they compete for the same replication control machinery within the cell. Most plasmids encode a negative...through inhibiting translation of replication machinery proteins, or directly inhibit replication by binding...origin of replication and blocking replication machinery (del Solar, 1998). As the copy number of the plasmid... structure that physically blocks replication machinery when plasmid copy number is high (del Solar et...replication of each plasmid using unique replication machinery. However, when plasmids have the same origin of...