...egularly I nterspaced S hort P alindromic R epeats) pathway, as an RNA-guided DNA binding platform, to repress...mutagenesis ( Cong et al. , Mali et al. , Jiang et al. , Hwang et al. ), is that the nuclease-deficient mutant ...

...efficiency of homology-directed repair (HDR), the pathway for resolving DNA double-strand breaks (DSBs) preferred..., P., Lee, K. D., Ortega, M. A., Sawyer, C., Schwaegerle, N. D., Peraro, L., Young, L., Lee, S.-J., Ciaramella...

...because the non-homologous end-joining (NHEJ) repair pathway is not very robust. In many cases, homology-directed...natural products. To easily explore and engineer pathways within this genus, Huimin Zhao’s lab created two...

... a microbial pathogen, they trigger signalling pathways that lead to the activation of an immune response...PIG4, SAA, TP53I4 SAA2 serum amyloid A2 - SBDS Shwachman-Bodian-Diamond syndrome CGI-97, FLJ10917, SDS,...of alpha-syn(A53T). Target Accelerator Genetic Pathway Reference Set : From Jesse Boehm , William Hahn...ORFs that represent over 25 cellular signaling pathways and processes. Addgene Blogs Adeno Associated ...

...fibroblasts via microRNA-dependent and -independent pathways. EMBO Mol Med. 2017 Aug;9(8):1117-1131. Parmar...modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into...

...Chemogenetic tools are actuators for specific cellular pathways, receptors, or ion channels targeted to specific...biological processes, including initiating signaling pathways in inflammation and neurotransmission. This, and...

...use in basic biology, for example, by targeting pathways underlying cancer or other disease processes. ...

...understand how a given gene is involved in a complex pathway. Some of the most heavily-studied genes in cancer...

... that routes the protein through the secretory pathway to improve folding and disulfide bond formation...

...What led you to it? Howarth: Our collaborator Uli Schwarz-Linek at St. Andrews discovered the domain. It ...

...Mapping the brainDissecting circuits Studying GPCR pathways   Acknowledgements We thank the Bryan Roth...

...activates the immune system's classical complement pathway, starting a cascade of events that results in the...

... References Lorsch JR, Collins FS, Lippincott-Schwartz J. Cell biology. Fixing problems with cell lines...

...specific stimulus. While the escape response neural pathway is well characterized, there is much left to be...

...nearly infinite regulatory capabilities of gene pathways just waiting to be discovered. As we started building...

...any researchers working on ACVR1 or any of the pathways that impinge upon FOP to deposit their plasmids...

...to follow the design, execute, analyze, repeat pathway that is required of scientists.” Professor George...

...settling down into a singular focus on molecular pathways, I found myself curious about other routes – In...

...chemogenetics communities to activate neurons and neuronal pathways using light and chemicals respectively. Didem ...

...transferrable across host species or metabolic pathways. A new study takes us one step closer to the vision...