...general repair pathways: the efficient but error-prone non-homologous end joining (NHEJ) pathway and the less...occurring repair pathway and is the primary repair mechanism for DSBs. While this pathway is efficient in...but high-fidelity homology directed repair (HDR) pathway. HDR relies on copying DNA from a matching template...involved in NHEJ or upregulating those in the HDR pathway can also help. Additionally, constructs with Cas9...fused components that promote the intended repair pathway or inhibit unwanted ones and improve editing efficiency...However, they promote the base excision repair pathway, which fully removes the uridine from the DNA and...evolved to excise inosine to access the same repair pathway and convert A to any other base. In principle, ...

...Chemogenetic tools are actuators for specific cellular pathways targeted to specific cell populations (most often...biological processes, including initiating signalling pathways in inflammation and neurotransmission. This, and...

...selectively control and investigate cell signaling pathways. Receptors are remotely controlled via small molecules...