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Bassik lab Mouse CRISPR-Cas9 Deletion Library - Unassigned1

Pooled Library

#1000000127

Purpose

CRISPR gRNA mouse knockout pooled library - Unassigned1

Depositor

Michael Bassik

Available since

May 23, 2018

Availability

Academic Institutions and Nonprofits only
Bassik lab Mouse CRISPR-Cas9 Deletion Library - Unassigned2

Pooled Library

#1000000128

Purpose

CRISPR gRNA mouse knockout pooled library - Unassigned2

Depositor

Michael Bassik

Available since

May 23, 2018

Availability

Academic Institutions and Nonprofits only
mCRISPRa-v2, Mitochondria, Trafficking, and Motility (m4), top 5 sgRNAs/gene

Pooled Library

#84001

Purpose

Mouse CRISPRa Pooled Library targeting Mitochondria, Trafficking, and Motility genes

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
mCRISPRa-v2, Stress and Proteostasis (m3), top 5 sgRNAs/gene

Pooled Library

#84000

Purpose

Mouse CRISPRi Pooled Library targeting stress and proteostasis genes

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
mCRISPRa-v2, Unassigned (m7), top 5 sgRNAs/gene

Pooled Library

#84004

Purpose

Mouse CRISPRa Pooled Library targeting unassigned genes

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
Bassik lab Mouse CRISPR-Cas9 Deletion Library - Mouse unique 2

Pooled Library

#1000000130

Purpose

CRISPR gRNA mouse knockout pooled library - Mouse Unique2

Depositor

Michael Bassik

Available since

May 23, 2018

Availability

Academic Institutions and Nonprofits only
Bassik lab Mouse CRISPR-Cas9 Deletion Library - Mouse unique 1

Pooled Library

#1000000129

Purpose

CRISPR gRNA mouse knockout pooled library - Mouse Unique1

Depositor

Michael Bassik

Available since

May 23, 2018

Availability

Academic Institutions and Nonprofits only
Human Brunello kinome pooled library, guides 1-4 in lentiCRISPRv2 backbone

Pooled Library

#75314

Purpose

Human sgRNA library in backbone lentiCRISPRv2 targeting 763 kinase genes and containing 3,052 unique sgRNAs along with 100 non-targeting controls

Depositor

David Root, John Doench

Article

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

June 27, 2016

Availability

Academic Institutions and Nonprofits only
Synuclein VHH Immune Library

Pooled Library

#1000000071

Purpose

Synuclein phagemid VHH phage display library

Depositor

Anne Messer, Michael J Fox Foundation MJFF

Available since

June 14, 2016

Availability

Industry, Academic Institutions, and Nonprofits
TP53 MITE Library

Pooled Library

#113569

Purpose

Pooled lentiviral plasmid library containing ~8,000 single amino acid substitution and nonsense mutant variants of p53

Depositor

David Root, William Hahn

Article

Giacomelli et al Nat Genet. 2018 Oct;50(10):1381-1387. do

Expression

Mammalian

Species

Homo sapiens

Use

Lentiviral

Available since

Jan. 4, 2019

Availability

Academic Institutions and Nonprofits only
SPLINTR GFP v1

Pooled Library

#179774

Purpose

SPLINTR (Single-cell Profiling and LINeage TRacing) is a high diversity lentiviral barcode library for tracing clonal lineages using bulk and single-cell readouts.

Depositor

Mark Dawson

Article

Fennell et al Nature. 2022 Jan;601(7891):125-131. doi:

Expression

Mammalian

Use

Lentiviral

Available since

May 11, 2022

Availability

Academic Institutions and Nonprofits only
hCRISPRi-v2, Membrane Proteins (h6), top 5 sgRNAs/gene

Pooled Library

#83976

Purpose

Human CRISPRi Pooled Library targeting membrane proteins

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Dec. 14, 2016

Availability

Academic Institutions and Nonprofits only
mCRISPRa-v2, Kinases, Phosphatases, and Drug Targets (m1), top 5 sgRNAs/gene

Pooled Library

#83998

Purpose

Mouse CRISPRi Pooled Library tartgeting kinsases, phosphatases and Drug Targets

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
Liu Lab MusCK (A + B)

Pooled Library

#1000000178

Depositor

Xiaole Shirley Liu

Available since

Oct. 29, 2021

Availability

Academic Institutions and Nonprofits only
Sabatini/Lander Lab Activity-Optimized Genome-wide Human sgRNA Library in lentiCRISPR v1

Pooled Library

#1000000100

Purpose

CRISPR gRNA knockout pooled library (version 1) for targeting the human genome

Depositor

David Sabatini, Eric Lander

Available since

April 3, 2017

Availability

Academic Institutions and Nonprofits only
Liu Mouse CRISPR Knockout Library in lentiCRISPRv2-blast

Pooled Library

#1000000173

Depositor

Xiaole Shirley Liu

Available since

May 13, 2021

Availability

Academic Institutions and Nonprofits only
Green monkey (Chlorocebus sabaeus) sgRNA library

Pooled Library

#178284

Purpose

Genome-wide CRISPR screening library targeting 20,991 genes in C. sabaeus, 84,963 total gRNAs

Depositor

David Root, John Doench

Article

Wei et al Cell. 2021 Jan 7;184(1):76-91.e13. doi:

Expression

Mammalian

Species

Chlorocebus sabaeus (african green monkey)

Use

CRISPR and Lentiviral

Available since

Nov. 23, 2021

Availability

Academic Institutions and Nonprofits only
CRISPRi non-coding library (CRiNCL) - Unique to HEK293T

Pooled Library

#86543

Depositor

Jonathan Weissman

Article

Liu et al Science. 2017 Jan 06. Vol. 355, Issue 63

Available since

March 8, 2017

Availability

Academic Institutions and Nonprofits only
Sabatini/Lander Lab Activity-Optimized Genome-wide Mouse sgRNA Library in pLenti-sgRNA

Pooled Library

#1000000096

Purpose

CRISPR gRNA knockout pooled library for targeting the mouse genome

Depositor

David Sabatini, Eric Lander

Available since

April 3, 2017

Availability

Academic Institutions and Nonprofits only
pRep-Cap Scanning Saturation Mutagenesis (SSM) pooled library

Pooled Library

#199601

Purpose

pRep-Cap SSM library enables VP1, VP2, and VP3 expression under the control of the endogenous p40 promoter

Depositor

George Church

Article

Ogden et al Science. 2019 Nov 29;366(6469):1139-1143

Expression

Mammalian

Species

Aav2

Use

AAV

Available since

June 13, 2023

Availability

Academic Institutions and Nonprofits only
Human SAM Library in lenti sgRNA(MS2)_zeo backbone

Pooled Library

#1000000057

Purpose

Genome-wide CRISPR gRNA pooled library for activation of human genes

Depositor

Feng Zhang

Available since

Jan. 16, 2015

Availability

Academic Institutions and Nonprofits only
Human CRISPRa sgRNA library Calabrese in backbone XPR_502 (P65 HSF), Set A

Pooled Library

#92379

Purpose

CRISPRa

Depositor

David Root, John Doench

Article

Sanson et al Nat Commun. 2018 Dec 21;9(1):5416. doi:

Has Service

Lentiviral Prep

Use

Lentiviral

Available since

Aug. 3, 2017

Availability

Academic Institutions and Nonprofits only
mCRISPRi-v2, Membrane Proteins (m6), top 5 sgRNAs/gene

Pooled Library

#83994

Purpose

Mouse CRISPRi Pooled Library targeting membrane proteins

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
Pan-cancer CasRx lncRNA Albarossa library

Pooled Library

#212966

Purpose

The human CasRx CRISPR lentiviral library encodes 75,725 gRNA arrays (two gRNAs per array) targeting 24,171 lncRNAs.

Depositor

Roland Rad

Article

Montero et al Nat Methods. 2024 Feb 26. doi: 10.1038/s

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

Feb. 21, 2024

Availability

Academic Institutions and Nonprofits only
pSMAL-CellTag-V2

Pooled Library

#115644

Purpose

Viral barcoding library to combinatorially index cells for single-cell analysis of clonal dynamics

Depositor

Samantha Morris

Article

Biddy et al Nature. 2018 Dec;564(7735):219-224. doi:

Has Service

Concentrated Lentiviral Prep

Expression

Mammalian

Species

Synthetic

Use

Lentiviral

Available since

Dec. 5, 2018

Availability

Academic Institutions and Nonprofits only
pCVSN2c-MCP-oScarlet-KASH-6xMS2 Barcode Library

Pooled Library

#227672

Purpose

RVdG genome plasmids that carry an error-correctable barcode compatible with 3’ capture single cell or single nuclei RNA sequencing readout. For the production of CVS N2c strain G-deleted rabies virus

Depositor

Tomasz Nowakowski, Cathryn Cadwell

Article

Shin et al bioRxiv [Preprint]. 2024 Dec 11:2024.10.

Expression

Mammalian

Species

Synthetic

Available since

Feb. 12, 2025

Availability

Academic Institutions and Nonprofits only
pSMAL-CellTag-V3

Pooled Library

#115645

Purpose

Viral barcoding library to combinatorially index cells for single-cell analysis of clonal dynamics

Depositor

Samantha Morris

Article

Biddy et al Nature. 2018 Dec;564(7735):219-224. doi:

Has Service

Concentrated Lentiviral Prep

Expression

Mammalian

Species

Synthetic

Use

Lentiviral

Available since

Dec. 5, 2018

Availability

Academic Institutions and Nonprofits only
ClonTracer Barcoding Library (7.5 ug)

Pooled Library

#69830

Purpose

High complexity 30bp-long semi random DNA barcode library in lentiviral backbone

Depositor

Frank Stegmeier

Article

Bhang et al Nat Med. 2015 Apr 13. doi: 10.1038/nm.38

Expression

Mammalian

Species

Synthetic

Use

Lentiviral

Available since

Sept. 11, 2015

Availability

Academic Institutions and Nonprofits only
Human CRISPR Knockout Pooled Library (H3)

Pooled Library

#133914

Purpose

CRISPR gRNA knockout pooled library for targeting the human genome - version H3

Depositor

Xiaole Shirley Liu, Myles Brown

Expression

Mammalian

Species

Homo sapiens

Use

CRISPR and Lentiviral

Available since

Jan. 24, 2020

Availability

Academic Institutions and Nonprofits only
Mouse Validation (mVAL) CRISPR Library

Pooled Library

#159391

Purpose

Pooled CRISPR library targets core intrinsic immune evasion genes

Depositor

Jason Moffat

Article

Lawson et al Nature. 2020 Oct;586(7827):120-126. doi:

Expression

Mammalian

Species

Mus musculus

Use

CRISPR and Lentiviral

Available since

Nov. 9, 2020

Availability

Academic Institutions and Nonprofits only
Mouse Toronto KnockOut (mTKO) CRISPR Library - pLCKO2

Pooled Library

#159393

Purpose

Mouse lentiviral genome-wide CRISPR library

Depositor

Jason Moffat

Article

Lawson et al Nature. 2020 Oct;586(7827):120-126. doi:

Expression

Mammalian

Species

Mus musculus

Use

CRISPR and Lentiviral

Available since

Nov. 9, 2020

Availability

Academic Institutions and Nonprofits only
LX-miR

Pooled Library

#112200

Purpose

gRNA library targets human primary miRNAs

Depositor

Ren-Jang Lin

Article

Kurata et al RNA. 2018 May 2. pii: rna.066282.118. do

Expression

Mammalian

Species

Homo sapiens

Use

Lentiviral

Available since

Sept. 20, 2018

Availability

Academic Institutions and Nonprofits only
pre-associated oBC-minP-GFP-mBC backbone (p043)

Pooled Library

#194098

Purpose

pre-associated oBC-minP-GFP-mBC backbone (p043), can directly be used to deposit library of regulatory elements

Depositor

Jay Shendure

Article

Lalanne et al bioRxiv 2022.12.10.519236

Expression

Bacterial and Mammalian

Use

RNAi

Available since

April 3, 2024

Availability

Academic Institutions and Nonprofits only
Human Lentiviral sgRNA Library - Kinases

Pooled Library

#51044

Purpose

Sub-pool of Sabatini/Lander sgRNA library enriched for kinase targets.

Depositor

David Sabatini, Eric Lander

Article

Wang et al Science. 2014 Jan 3;343(6166):80-4. doi:

Expression

Mammalian

Species

Homo sapiens

Use

CRISPR and Lentiviral

Available since

Feb. 7, 2014

Availability

Academic Institutions and Nonprofits only
Bassik lab Mouse CRISPR-Cas9 Deletion Library - Apoptosis and cancer

Pooled Library

#1000000121

Purpose

CRISPR gRNA mouse knockout pooled library - Apoptosis and cancer

Depositor

Michael Bassik

Available since

May 23, 2018

Availability

Academic Institutions and Nonprofits only
Barcode Library 0 (BCL0)

Pooled Library

#179851

Purpose

Lentiviral barcode library that consists of 10^6 unique barcodes. Barcodes consist of 12bp degenerate region followed by two stable bases (C or G) and 4bp unique library code ACGT.

Depositor

Jason Moffat

Article

Rehman et al Cell. 2021 Jan 7;184(1):226-242.e21. doi

Expression

Mammalian

Use

Lentiviral

Available since

May 12, 2022

Availability

Academic Institutions and Nonprofits only
Wei lab paired-guide RNA (pgRNA) CRISPR–Cas9 library for human long non-coding RNAs (lncRNAs)

Pooled Library

#89640

Purpose

Paired sgRNA library containing 12,472 pgRNAs targeting 671 human long non-coding RNAs (lncRNAs)

Depositor

Wensheng Wei

Article

Zhu et al Nat Biotechnol. 2016 Dec;34(12):1279-128

Expression

Mammalian

Use

Lentiviral

Available since

May 17, 2017

Availability

Academic Institutions and Nonprofits only
pEPIP_PepTile_40merFragments_65CancerDrivers

Pooled Library

#172109

Purpose

Lentiviral peptide expression library for overexpression fitness screening

Depositor

Prashant Mali

Article

Ford et al Cell Syst. 2021 Jul 21;12(7):716-732.e7.

Use

Lentiviral

Available since

Oct. 21, 2021

Availability

Academic Institutions and Nonprofits only
Human Brunello kinome pooled library, guides 1-4 in lentiGuide-Puro backbone

Pooled Library

#75312

Purpose

Human sgRNA library in backbone lentiGuide-Puro targeting 763 kinase genes and containing 3,052 unique sgRNAs along with 100 non-targeting controls

Depositor

David Root, John Doench

Article

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

June 27, 2016

Availability

Academic Institutions and Nonprofits only
pCMV-Rep78/68 Scanning Saturation Mutagenesis (SSM)

Pooled Library

#198050

Purpose

By supplying an AAV cap gene of interest in trans, researchers can use this library to investigate the effects of rep mutations on production of a wide range of AAV capsid serotypes

Depositor

George Church

Article

Jain et al bioRxiv 2023.01.31.526541

Expression

Mammalian

Use

AAV

Available since

May 4, 2023

Availability

Academic Institutions and Nonprofits only
Bassik lab Mouse CRISPR-Cas9 Deletion Library - Stress Proteostasis

Pooled Library

#1000000125

Purpose

CRISPR gRNA mouse knockout pooled library - Stress proteostasis

Depositor

Michael Bassik

Available since

May 23, 2018

Availability

Academic Institutions and Nonprofits only
Human Lentiviral sgRNA Library - Nuclear

Pooled Library

#51047

Purpose

Sub-pool of Sabatini/Lander sgRNA library enriched for nuclear targets.

Depositor

David Sabatini, Eric Lander

Article

Wang et al Science. 2014 Jan 3;343(6166):80-4. doi:

Expression

Mammalian

Species

Homo sapiens

Use

CRISPR and Lentiviral

Available since

Feb. 7, 2014

Availability

Academic Institutions and Nonprofits only
mCRISPRa-v2, genome-wide, 10 sgRNAs/gene

Pooled Library

#1000000093

Purpose

Genome-wide CRISPR gRNA pooled library for activation of mouse genes

Depositor

Jonathan Weissman

Available since

Nov. 15, 2016

Availability

Academic Institutions and Nonprofits only
RLC11

Pooled Library

#163955

Purpose

RLC11 pooled library

Depositor

Jeremy Rock

Article

Bosch et al Cell. 2021 Jul 16. pii: S0092-8674(21)00

Expression

Bacterial

Use

CRISPR

Available since

Oct. 1, 2021

Availability

Academic Institutions and Nonprofits only
Human lentiviral CRISPR library_v1

Pooled Library

#69763

Purpose

Genome-scale sgRNA screening library in lentiviral vector pLB, targeting 20,121 human protein-coding genes

Depositor

Haoquan Wu

Article

Ma et al Cell Rep. 2015 Jul 28;12(4):673-83. doi:

Expression

Mammalian

Species

Homo sapiens

Use

CRISPR and Lentiviral

Available since

Feb. 9, 2016

Availability

Academic Institutions and Nonprofits only
hCRISPRa_dual_1_2

Pooled Library

#187249

Purpose

Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

Depositor

Jonathan Weissman, Marco Jost

Article

Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

Species

Synthetic

Use

Lentiviral

Available since

Sept. 30, 2022

Availability

Academic Institutions and Nonprofits only
PYR1 Double Mutant Library

Pooled Library

#1000000181

Depositor

Timothy Whitehead

Available since

June 21, 2022

Availability

Academic Institutions and Nonprofits only
Humagne Set C

Pooled Library

#172650

Purpose

Set C contains best-ranked guides 1 and 4.

Depositor

David Root, John Doench

Article

DeWeirdt et al Nat Biotechnol. 2020 Jul 13. pii: 10.103

Expression

Mammalian

Available since

Nov. 10, 2021

Availability

Academic Institutions and Nonprofits only
STICR_Index3

Pooled Library

#186335

Purpose

High Complexity Lentiviral Barcode Library

Depositor

Tomasz Nowakowski

Article

Delgado et al Nature. 2021 Dec 15. pii: 10.1038/s41586

Expression

Mammalian

Species

Synthetic

Use

Lentiviral

Available since

Sept. 12, 2022

Availability

Academic Institutions and Nonprofits only
Humagne Set D

Pooled Library

#172651

Purpose

Set D contains best-ranked guides 2 and 3.

Depositor

David Root, John Doench

Article

DeWeirdt et al Nat Biotechnol. 2020 Jul 13. pii: 10.103

Expression

Mammalian

Available since

Nov. 10, 2021

Availability

Academic Institutions and Nonprofits only

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