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Comprehensive mutagenesis maps the effect of all single codon mutations in the AAV2 rep gene on AAV production

Jain NK, Ogden PJ, Church GM
bioRxiv 2023.01.31.526541 (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
198014pCMV-AAV2capFor high-level expression of the AAV2 cap gene, suitable for use with pCMV-Rep78/68 SSM library
198015pCMV-AAV5capFor high-level expression of the AAV5 cap gene, suitable for use with pCMV-Rep78/68 SSM library
198016pCMV-AAV9capFor high-level expression of the AAV9 cap gene, suitable for use with pCMV-Rep78/68 SSM library
198050pCMV-Rep78/68 Scanning Saturation Mutagenesis (SSM)By supplying an AAV cap gene of interest in trans, researchers can use this library to investigate the effects of rep mutations on production of a wide range of AAV capsid serotypes

Antibodies from Article