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LRBA Deficiency Can Lead to Lethal Colitis That Is Diminished by SHIP1 Agonism.

Sudan R, Fernandes S, Srivastava N, Pedicone C, Meyer ST, Chisholm JD, Engelman RW, Kerr WG
Front Immunol. 2022 May 4;13:830961. doi: 10.3389/fimmu.2022.830961. eCollection 2022. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
183767pS97splitRBP_S1-EnzExpresses SHIP1-Enzyme domain flanked by RBP
183768pS97splitRBP_S2-EnzExpresses SHIP2-Enzyme domain flanked by RBP
183769pS97splitRBP_S1dC2Expresses SHIP1-delta-C2-Enzyme domain flanked by RBP
183770pET24TEV-tSHIP1Expresses C-terminal truncated SHIP1 (tSHIP1)with C-terminal TEV and 6HIS tags from pET24 backbone
183771pET24TEV-tSHIP2Expresses C-terminal truncated SHIP2 (tSHIP2) with C-terminal TEV and 6HIS tags from pET24 backbone

Antibodies from Article