pLKO.1 puro Citations (401)
Originally described in: Lentivirus-delivered stable gene silencing by RNAi in primary cells.Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD RNA 2003 Apr;9(4):493-501. PubMed Journal
Articles Citing pLKO.1 puro
| Articles |
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PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.
Wang L, Harris TE, Roth RA, Lawrence JC.
J Biol Chem. 2007 Jul 6. 282(27):20036-44.
PubMed
Associated Plasmids |
| Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR. Tzatsos A. J Biol Chem. 2009 Aug 21;284(34):22525-34. doi: 10.1074/jbc.M109.027748. Epub 2009 Jun 26. PubMed |
| Identification of prospective factors promoting osteotropism in breast cancer: a potential role for CITED2. Lau WM, Weber KL, Doucet M, Chou YT, Brady K, Kowalski J, Tsai HL, Yang J, Kominsky SL. Int J Cancer. 2010 Feb 15;126(4):876-84. doi: 10.1002/ijc.24780. PubMed |
| Phagocytosis of cells dying through autophagy induces inflammasome activation and IL-1beta release in human macrophages. Petrovski G, Ayna G, Majai G, Hodrea J, Benko S, Madi A, Fesus L. Autophagy. 2011 Mar;7(3):321-30. PubMed |
| Scavenger receptor WC1 contributes to the gammadelta T cell response to Leptospira. Wang F, Herzig CT, Chen C, Hsu H, Baldwin CL, Telfer JC. Mol Immunol. 2011 Mar;48(6-7):801-9. doi: 10.1016/j.molimm.2010.12.001. Epub 2011 Jan 11. PubMed |
| JNK signaling promotes intestinal tumorigenesis through activation of mTOR complex 1 in Apc(Delta716) mice. Fujishita T, Aoki M, Taketo MM. Gastroenterology. 2011 May;140(5):1556-63.e6. doi: 10.1053/j.gastro.2011.02.007. Epub 2011 Feb 12. PubMed |
| Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. Kawazu M, Saso K, Tong KI, McQuire T, Goto K, Son DO, Wakeham A, Miyagishi M, Mak TW, Okada H. PLoS One. 2011 Mar 18;6(3):e17830. doi: 10.1371/journal.pone.0017830. PubMed |
| The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, Metzen E. PLoS One. 2011 Apr 29;6(4):e19151. doi: 10.1371/journal.pone.0019151. PubMed |
Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP.
Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ.
Oncogene. 2012 Jan 12;31(2):238-50. doi: 10.1038/onc.2011.224. Epub 2011 Jun 13.
PubMed
Associated Plasmids |
| Loss of DLK expression in WI-38 human diploid fibroblasts induces a senescent-like proliferation arrest. Daviau A, Couture JP, Blouin R. Biochem Biophys Res Commun. 2011 Sep 23;413(2):282-7. doi: 10.1016/j.bbrc.2011.08.086. Epub 2011 Aug 27. PubMed |
| Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis. Belyea BC, Naini S, Bentley RC, Linardic CM. Clin Cancer Res. 2011 Dec 1;17(23):7324-36. doi: 10.1158/1078-0432.CCR-11-1004. Epub 2011 Sep 23. PubMed |
| The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cordenonsi M, Zanconato F, Azzolin L, Forcato M, Rosato A, Frasson C, Inui M, Montagner M, Parenti AR, Poletti A, Daidone MG, Dupont S, Basso G, Bicciato S, Piccolo S. Cell. 2011 Nov 11;147(4):759-72. doi: 10.1016/j.cell.2011.09.048. PubMed |
| FGF signalling inhibits neural induction in human embryonic stem cells. Greber B, Coulon P, Zhang M, Moritz S, Frank S, Muller-Molina AJ, Arauzo-Bravo MJ, Han DW, Pape HC, Scholer HR. EMBO J. 2011 Nov 15;30(24):4874-84. doi: 10.1038/emboj.2011.407. PubMed |
| Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Piskounova E, Polytarchou C, Thornton JE, LaPierre RJ, Pothoulakis C, Hagan JP, Iliopoulos D, Gregory RI. Cell. 2011 Nov 23;147(5):1066-79. doi: 10.1016/j.cell.2011.10.039. PubMed |
| gamma-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis. Vinopal S, Cernohorska M, Sulimenko V, Sulimenko T, Vosecka V, Flemr M, Draberova E, Draber P. PLoS One. 2012;7(1):e29919. doi: 10.1371/journal.pone.0029919. Epub 2012 Jan 3. PubMed |
| The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer. Al Sorkhy M, Ferraiuolo RM, Jalili E, Malysa A, Fratiloiu AR, Sloane BF, Porter LA. BMC Cancer. 2012 Jan 26;12:45. doi: 10.1186/1471-2407-12-45. PubMed |
| Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency. Lee DF, Su J, Sevilla A, Gingold J, Schaniel C, Lemischka IR. Nat Protoc. 2012 Mar 22;7(4):729-48. doi: 10.1038/nprot.2012.018. PubMed |
KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals.
Moleirinho S, Chang N, Sims AH, Tilston-Lunel AM, Angus L, Steele A, Boswell V, Barnett SC, Ormandy C, Faratian D, Gunn-Moore FJ, Reynolds PA.
Oncogene. 2012 May 21. doi: 10.1038/onc.2012.196.
PubMed
Associated Plasmids |
| FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma. Crose LE, Etheridge KT, Chen C, Belyea B, Talbot LJ, Bentley RC, Linardic CM. Clin Cancer Res. 2012 Jul 15;18(14):3780-90. doi: 10.1158/1078-0432.CCR-10-3063. Epub 2012 May 30. PubMed |
| Inverted Alu dsRNA structures do not affect localization but can alter translation efficiency of human mRNAs independent of RNA editing. Capshew CR, Dusenbury KL, Hundley HA. Nucleic Acids Res. 2012 Sep 1;40(17):8637-45. Epub 2012 Jun 25. PubMed |
| New insight into the SDF-1/CXCR4 axis in a breast carcinoma model: hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation. Jin F, Brockmeier U, Otterbach F, Metzen E. Mol Cancer Res. 2012 Aug;10(8):1021-31. doi: 10.1158/1541-7786.MCR-11-0498. Epub 2012 Jul 5. PubMed |
| The oncogene LRF is a survival factor in chondrosarcoma and contributes to tumor malignancy and drug resistance. Kumari R, Li H, Haudenschild DR, Fierro F, Carlson CS, Overn P, Gupta L, Gupta K, Nolta J, Yik JH, Di Cesare PE. Carcinogenesis. 2012 Nov;33(11):2076-83. doi: 10.1093/carcin/bgs254. Epub 2012 Jul 30. PubMed |
| High-mobility group box 2 (HMGB2) modulates radioresponse and is downregulated by p53 in colorectal cancer cell. Shin YJ, Kim MS, Kim MS, Lee J, Kang M, Jeong JH. Cancer Biol Ther. 2013 Mar;14(3):213-21. doi: 10.4161/cbt.23292. Epub 2012 Dec 19. PubMed |
| Gene transduction in human monocyte-derived dendritic cells using lentiviral vectors. Satoh T, Manel N. Methods Mol Biol. 2013;960:401-9. doi: 10.1007/978-1-62703-218-6_30. PubMed |
| alpha-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKalpha in vitro. Wang L, Brautigan DL. Nat Commun. 2013;4:1559. doi: 10.1038/ncomms2565. PubMed |
| Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease. Tang Z, Bereczki E, Zhang H, Wang S, Li C, Ji X, Branca RM, Lehtio J, Guan Z, Filipcik P, Xu S, Winblad B, Pei JJ. J Biol Chem. 2013 May 31;288(22):15556-70. doi: 10.1074/jbc.M112.435123. Epub 2013 Apr 12. PubMed |
| Cadherin-17 interacts with alpha2beta1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis. Bartolome RA, Barderas R, Torres S, Fernandez-Acenero MJ, Mendes M, Garcia-Foncillas J, Lopez-Lucendo M, Casal JI. Oncogene. 2014 Mar 27;33(13):1658-69. doi: 10.1038/onc.2013.117. Epub 2013 Apr 22. PubMed |
| Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2). Janke K, Brockmeier U, Kuhlmann K, Eisenacher M, Nolde J, Meyer HE, Mairbaurl H, Metzen E. J Cell Sci. 2013 Jun 15;126(Pt 12):2629-40. doi: 10.1242/jcs.117564. Epub 2013 Apr 19. PubMed |
| Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia. Willems L, Jacque N, Jacquel A, Neveux N, Maciel TT, Lambert M, Schmitt A, Poulain L, Green AS, Uzunov M, Kosmider O, Radford-Weiss I, Moura IC, Auberger P, Ifrah N, Bardet V, Chapuis N, Lacombe C, Mayeux P, Tamburini J, Bouscary D. Blood. 2013 Nov 14;122(20):3521-32. doi: 10.1182/blood-2013-03-493163. Epub 2013 Sep 6. PubMed |
| miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis. Fu X, Meng Z, Liang W, Tian Y, Wang X, Han W, Lou G, Wang X, Lou F, Yen Y, Yu H, Jove R, Huang W. Oncogene. 2014 Aug 21;33(34):4296-306. doi: 10.1038/onc.2013.385. Epub 2013 Sep 23. PubMed |
| Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 4. Ieguchi K, Omori T, Komatsu A, Tomita T, Deguchi A, Maru Y. Biochem Biophys Res Commun. 2013 Nov 1;440(4):623-9. doi: 10.1016/j.bbrc.2013.09.119. Epub 2013 Oct 5. PubMed |
| Lentiviral overexpression of miRNAs. Zollner H, Hahn SA, Maghnouj A. Methods Mol Biol. 2014;1095:177-90. doi: 10.1007/978-1-62703-703-7_15. PubMed |
| PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells. Okashita N, Kumaki Y, Ebi K, Nishi M, Okamoto Y, Nakayama M, Hashimoto S, Nakamura T, Sugasawa K, Kojima N, Takada T, Okano M, Seki Y. Development. 2014 Jan;141(2):269-80. doi: 10.1242/dev.099622. Epub 2013 Dec 11. PubMed |
| microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. Offer SM, Butterfield GL, Jerde CR, Fossum CC, Wegner NJ, Diasio RB. Mol Cancer Ther. 2014 Mar;13(3):742-51. doi: 10.1158/1535-7163.MCT-13-0878. Epub 2014 Jan 8. PubMed |
| Plakoglobin but not desmoplakin regulates keratinocyte cohesion via modulation of p38MAPK signaling. Spindler V, Dehner C, Hubner S, Waschke J. J Invest Dermatol. 2014 Jun;134(6):1655-64. doi: 10.1038/jid.2014.21. Epub 2014 Jan 17. PubMed |
| Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines. Yik JH, Hu Z, Kumari R, Christiansen BA, Haudenschild DR. Arthritis Rheumatol. 2014 Jun;66(6):1537-46. doi: 10.1002/art.38378. PubMed |
| Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Niu Y, Shen B, Cui Y, Chen Y, Wang J, Wang L, Kang Y, Zhao X, Si W, Li W, Xiang AP, Zhou J, Guo X, Bi Y, Si C, Hu B, Dong G, Wang H, Zhou Z, Li T, Tan T, Pu X, Wang F, Ji S, Zhou Q, Huang X, Ji W, Sha J. Cell. 2014 Feb 13;156(4):836-43. doi: 10.1016/j.cell.2014.01.027. Epub 2014 Jan 30. PubMed |
Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.
Shen B, Zhang W, Zhang J, Zhou J, Wang J, Chen L, Wang L, Hodgkins A, Iyer V, Huang X, Skarnes WC.
Nat Methods. 2014 Mar 2. doi: 10.1038/nmeth.2857.
PubMed
Associated Plasmids |
| hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. Perez-Gonzalez A, Pazo A, Navajas R, Ciordia S, Rodriguez-Frandsen A, Nieto A. PLoS One. 2014 Mar 7;9(3):e90957. doi: 10.1371/journal.pone.0090957. eCollection 2014. PubMed |
Anoctamin 6 regulates C2C12 myoblast proliferation.
Zhao P, Torcaso A, Mariano A, Xu L, Mohsin S, Zhao L, Han R.
PLoS One. 2014 Mar 24;9(3):e92749. doi: 10.1371/journal.pone.0092749. eCollection 2014.
PubMed
Associated Plasmids |
| ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism. Yang Y, Ahn YH, Chen Y, Tan X, Guo L, Gibbons DL, Ungewiss C, Peng DH, Liu X, Lin SH, Thilaganathan N, Wistuba II, Rodriguez-Canales J, McLendon G, Creighton CJ, Kurie JM. J Clin Invest. 2014 Jun;124(6):2696-708. doi: 10.1172/JCI72171. Epub 2014 Apr 24. PubMed |
| MS4A8B promotes cell proliferation in prostate cancer. Ye L, Yao XD, Wan FN, Qu YY, Liu ZY, Shen XX, Li S, Liu XJ, Yue F, Wang N, Dai B, Ye DW. Prostate. 2014 Jun;74(9):911-22. doi: 10.1002/pros.22802. Epub 2014 Apr 30. PubMed |
| Murine norovirus: propagation, quantification, and genetic manipulation. Hwang S, Alhatlani B, Arias A, Caddy SL, Christodoulou C, Cunha JB, Emmott E, Gonzalez-Hernandez M, Kolawole A, Lu J, Rippinger C, Sorgeloos F, Thorne L, Vashist S, Goodfellow I, Wobus CE. Curr Protoc Microbiol. 2014 May 1;33:15K.2.1-61. doi: 10.1002/9780471729259.mc15k02s33. PubMed |
| SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma. Siegle JM, Basin A, Sastre-Perona A, Yonekubo Y, Brown J, Sennett R, Rendl M, Tsirigos A, Carucci JA, Schober M. Nat Commun. 2014 Jul 31;5:4511. doi: 10.1038/ncomms5511. PubMed |
| Goat activin receptor type IIB knockdown by muscle specific promoter driven artificial microRNAs. Patel AK, Shah RK, Patel UA, Tripathi AK, Joshi CG. J Biotechnol. 2014 Oct 10;187:87-97. doi: 10.1016/j.jbiotec.2014.07.450. Epub 2014 Aug 7. PubMed |
| Regulation of mitochondrial function and cellular energy metabolism by protein kinase C-lambda/iota: a novel mode of balancing pluripotency. Mahato B, Home P, Rajendran G, Paul A, Saha B, Ganguly A, Ray S, Roy N, Swerdlow RH, Paul S. Stem Cells. 2014 Nov;32(11):2880-92. doi: 10.1002/stem.1817. PubMed |
| ETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells. Plotnik JP, Budka JA, Ferris MW, Hollenhorst PC. Nucleic Acids Res. 2014 Oct 29;42(19):11928-40. doi: 10.1093/nar/gku929. Epub 2014 Oct 7. PubMed |
| An optical labeling-based proliferation assay system reveals the paracrine effect of interleukin-6 in breast cancer. Itou J, Tanaka S, Sato F, Akiyama R, Kawakami Y, Toi M. Biochim Biophys Acta. 2015 Jan;1853(1):27-40. doi: 10.1016/j.bbamcr.2014.10.004. Epub 2014 Oct 12. PubMed |
| JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress. Kostecka A, Sznarkowska A, Meller K, Acedo P, Shi Y, Mohammad Sakil HA, Kawiak A, Lion M, Krolicka A, Wilhelm M, Inga A, Zawacka-Pankau J. Cell Death Dis. 2014 Oct 23;5:e1484. doi: 10.1038/cddis.2014.408. PubMed |
| MicroRNA-29c/PTEN pathway is involved in mice brain development and modulates neurite outgrowth in PC12 cells. Zou H, Ding Y, Shi W, Xu X, Gong A, Zhang Z, Liu J. Cell Mol Neurobiol. 2015 Apr;35(3):313-22. doi: 10.1007/s10571-014-0126-x. Epub 2014 Oct 29. PubMed |
| Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Mitter SK, Song C, Qi X, Mao H, Rao H, Akin D, Lewin A, Grant M, Dunn W Jr, Ding J, Bowes Rickman C, Boulton M. Autophagy. 2014;10(11):1989-2005. doi: 10.4161/auto.36184. PubMed |
| YAP-mediated induction of monoacylglycerol lipase restrains oncogenic transformation. Tang ED, Wang CY. Cell Signal. 2015 Apr;27(4):836-40. doi: 10.1016/j.cellsig.2015.01.011. Epub 2015 Jan 28. PubMed |
| GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells. Bilal MY, Zhang EY, Dinkel B, Hardy D, Yankee TM, Houtman JC. Cell Signal. 2015 Apr;27(4):841-50. doi: 10.1016/j.cellsig.2015.01.012. Epub 2015 Jan 28. PubMed |
| EWI-2 negatively regulates TGF-beta signaling leading to altered melanoma growth and metastasis. Wang HX, Sharma C, Knoblich K, Granter SR, Hemler ME. Cell Res. 2015 Mar;25(3):370-85. doi: 10.1038/cr.2015.17. Epub 2015 Feb 6. PubMed |
| MicroRNA-29A/PTEN pathway modulates neurite outgrowth in PC12 cells. Zou H, Ding Y, Wang K, Xiong E, Peng W, Du F, Zhang Z, Liu J, Gong A. Neuroscience. 2015 Apr 16;291:289-300. doi: 10.1016/j.neuroscience.2015.01.055. Epub 2015 Feb 7. PubMed |
| miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPbeta. Zhang XF, Li KK, Gao L, Li SZ, Chen K, Zhang JB, Wang D, Tu RF, Zhang JX, Tao KX, Wang G, Zhang XD. Oncotarget. 2015 Feb 28;6(6):4144-58. PubMed |
| GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-gamma1 Activation and Cytokine Production. Bilal MY, Houtman JC. Front Immunol. 2015 Mar 30;6:141. doi: 10.3389/fimmu.2015.00141. eCollection 2015. PubMed |
| Leukemia stem cells in T-ALL require active Hif1alpha and Wnt signaling. Giambra V, Jenkins CE, Lam SH, Hoofd C, Belmonte M, Wang X, Gusscott S, Gracias D, Weng AP. Blood. 2015 Jun 18;125(25):3917-27. doi: 10.1182/blood-2014-10-609370. Epub 2015 May 1. PubMed |
| Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia. Sujobert P, Poulain L, Paubelle E, Zylbersztejn F, Grenier A, Lambert M, Townsend EC, Brusq JM, Nicodeme E, Decrooqc J, Nepstad I, Green AS, Mondesir J, Hospital MA, Jacque N, Christodoulou A, Desouza TA, Hermine O, Foretz M, Viollet B, Lacombe C, Mayeux P, Weinstock DM, Moura IC, Bouscary D, Tamburini J. Cell Rep. 2015 Jun 9;11(9):1446-57. doi: 10.1016/j.celrep.2015.04.063. Epub 2015 May 21. PubMed |
| Optimization of methods for the genetic modification of human T cells. Bilal MY, Vacaflores A, Houtman JC. Immunol Cell Biol. 2015 Nov;93(10):896-908. doi: 10.1038/icb.2015.59. Epub 2015 Jun 1. PubMed |
| Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma. Kephart JJ, Tiller RG, Crose LE, Slemmons KK, Chen PH, Hinson AR, Bentley RC, Chi JT, Linardic CM. Clin Cancer Res. 2015 Nov 1;21(21):4868-80. doi: 10.1158/1078-0432.CCR-14-1797. Epub 2015 Jun 12. PubMed |
| Critical role of Wnt/beta-catenin signaling in driving epithelial ovarian cancer platinum resistance. Nagaraj AB, Joseph P, Kovalenko O, Singh S, Armstrong A, Redline R, Resnick K, Zanotti K, Waggoner S, DiFeo A. Oncotarget. 2015 Sep 15;6(27):23720-34. PubMed |
| Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition. Jacque N, Ronchetti AM, Larrue C, Meunier G, Birsen R, Willems L, Saland E, Decroocq J, Thiago TT, Lambert M, Poulain L, Hospital MA, Sujobert P, Joseph L, Chapuis N, Lacombe C, Moura IC, Demo S, Sarry JE, Recher C, Mayeux P, Tamburini J, Bouscary D. Blood. 2015 Sep 10;126(11):1346-56. doi: 10.1182/blood-2015-01-621870. Epub 2015 Jul 17. PubMed |
| The Glycogen Synthase Kinase 3alpha and beta Isoforms Differentially Regulates Interleukin-12p40 Expression in Endothelial Cells Stimulated with Peptidoglycan from Staphylococcus aureus. Cortes-Vieyra R, Silva-Garcia O, Oviedo-Boyso J, Huante-Mendoza A, Bravo-Patino A, Valdez-Alarcon JJ, Finlay BB, Baizabal-Aguirre VM. PLoS One. 2015 Jul 22;10(7):e0132867. doi: 10.1371/journal.pone.0132867. eCollection 2015. PubMed |
| Myosin 1b Regulates Amino Acid Transport by Associating Transporters with the Apical Plasma Membrane of Kidney Cells. Komaba S, Coluccio LM. PLoS One. 2015 Sep 11;10(9):e0138012. doi: 10.1371/journal.pone.0138012. eCollection 2015. PubMed |
| LDL suppresses angiogenesis through disruption of the HIF pathway via NF-kappaB inhibition which is reversed by the proteasome inhibitor BSc2118. Yao G, Zhang Q, Doeppner TR, Niu F, Li Q, Yang Y, Kuckelkorn U, Hagemann N, Li W, Hermann DM, Dai Y, Zhou W, Jin F. Oncotarget. 2015 Oct 6;6(30):30251-62. doi: 10.18632/oncotarget.4943. PubMed |
| Paclitaxel-induced transcriptional regulation of Fas signaling pathway is antagonized by dexamethasone. Crozier M, Porter LA. Breast Cancer Res Treat. 2015 Nov;154(1):33-44. PubMed |
| Transcription factor CREB3L1 mediates cAMP and glucocorticoid regulation of arginine vasopressin gene transcription in the rat hypothalamus. Greenwood M, Greenwood MP, Mecawi AS, Loh SY, Rodrigues JA, Paton JF, Murphy D. Mol Brain. 2015 Oct 26;8(1):68. doi: 10.1186/s13041-015-0159-1. PubMed |
| Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-beta/RUNX axis. Anderson BD, Harris RS. Sci Adv. 2015 Sep 18;1(8):e1500296. doi: 10.1126/sciadv.1500296. eCollection 2015 Sep. PubMed |
| Human Umbilical Tissue-Derived Cells Promote Synapse Formation and Neurite Outgrowth via Thrombospondin Family Proteins. Koh S, Kim N, Yin HH, Harris IR, Dejneka NS, Eroglu C. J Neurosci. 2015 Nov 25;35(47):15649-65. doi: 10.1523/JNEUROSCI.1364-15.2015. PubMed |
| Rasd1, a small G protein with a big role in the hypothalamic response to neuronal activation. Greenwood MP, Greenwood M, Mecawi AS, Antunes-Rodrigues J, Paton JF, Murphy D. Mol Brain. 2016 Jan 7;9(1):1. doi: 10.1186/s13041-015-0182-2. PubMed |
| WNT/beta-catenin signaling mediates human neural crest induction via a pre-neural border intermediate. Leung AW, Murdoch B, Salem AF, Prasad MS, Gomez GA, Garcia-Castro MI. Development. 2016 Feb 1;143(3):398-410. doi: 10.1242/dev.130849. PubMed |
| Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL. Le Pen J, Laurent M, Sarosiek K, Vuillier C, Gautier F, Montessuit S, Martinou JC, Letai A, Braun F, Juin PP. Cell Death Dis. 2016 Feb 4;7:e2083. doi: 10.1038/cddis.2015.400. PubMed |
| CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer. Wright HJ, Arulmoli J, Motazedi M, Nelson LJ, Heinemann FS, Flanagan LA, Razorenova OV. Oncogene. 2016 Feb 15. doi: 10.1038/onc.2016.7. PubMed |
| Increased risk of interstitial lung disease in children with a single R288K variant of ABCA3. Wittmann T, Frixel S, Hoppner S, Schindlbeck U, Schams A, Kappler MV, Hegermann J, Wrede C, Liebisch G, Vierzig A, Zacharasiewicz A, Kopp M, Poets CF, Baden W, Hartl D, Van Kaam AH, Lohse P, Aslanidis C, Zarbock R, Griese M. Mol Med. 2016 Feb 26. pii: molmed.2015.00244. doi: 10.2119/molmed.2015.00244. PubMed |
| E-Cadherin repression increases amount of cancer stem cells in human A549 lung adenocarcinoma and stimulates tumor growth. Farmakovskaya M, Khromova N, Rybko V, Dugina V, Kopnin B, Kopnin P. Cell Cycle. 2016 Apr 17;15(8):1084-92. doi: 10.1080/15384101.2016.1156268. PubMed |
| Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates. Song HY, Park SH, Kang HJ, Vassilopoulos A. J Vis Exp. 2016 Feb 27;(108). doi: 10.3791/53563. PubMed |
| A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells. Li W, Itou J, Tanaka S, Nishimura T, Sato F, Toi M. Exp Cell Res. 2016 May 1;343(2):177-89. doi: 10.1016/j.yexcr.2016.03.023. Epub 2016 Mar 28. PubMed |
| A CRISPR-Based Toolbox for Studying T Cell Signal Transduction. Chi S, Weiss A, Wang H. Biomed Res Int. 2016;2016:5052369. doi: 10.1155/2016/5052369. Epub 2016 Feb 1. PubMed |
| ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells. Wang Y, Li Y, Guo C, Lu Q, Wang W, Jia Z, Chen P, Ma K, Reinberg D, Zhou C. Nucleic Acids Res. 2016 Apr 21. pii: gkw301. PubMed |
| Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness. Nguyen A, Yoshida M, Goodarzi H, Tavazoie SF. Nat Commun. 2016 May 3;7:11246. doi: 10.1038/ncomms11246. PubMed |
| KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification. Tetreault MP, Weinblatt D, Shaverdashvili K, Yang Y, Katz JP. Sci Rep. 2016 May 17;6:26130. doi: 10.1038/srep26130. PubMed |
| Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells. Tilston-Lunel AM, Haley KE, Schlecht NF, Wang Y, Chatterton AL, Moleirinho S, Watson A, Hundal HS, Prystowsky MB, Gunn-Moore FJ, Reynolds PA. J Mol Cell Biol. 2016 Apr 18. pii: mjw020. PubMed |
| CITED2 Modulates Breast Cancer Metastatic Ability Through Effects on IKKalpha. Jayaraman S, Doucet M, Lau WM, Kominsky SL. Mol Cancer Res. 2016 May 23. pii: molcanres.0081.2016. PubMed |
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| The cyclin-like protein, SPY1, regulates the ERalpha and ERK1/2 pathways promoting tamoxifen resistance. Ferraiuolo RM, Tubman J, Sinha I, Hamm C, Porter LA. Oncotarget. 2017 Apr 4;8(14):23337-23352. doi: 10.18632/oncotarget.15578. PubMed |
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A convenient method to pre-screen candidate guide RNAs for CRISPR/Cas9 gene editing by NHEJ-mediated integration of a 'self-cleaving' GFP-expression plasmid.
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| Rapamycin Modulates Glucocorticoid Receptor Function, Blocks Atrophogene REDD1, and Protects Skin from Steroid Atrophy. Lesovaya E, Agarwal S, Readhead B, Vinokour E, Baida G, Bhalla P, Kirsanov K, Yakubovskaya M, Platanias LC, Dudley JT, Budunova I. J Invest Dermatol. 2018 Sep;138(9):1935-1944. doi: 10.1016/j.jid.2018.02.045. Epub 2018 Mar 27. PubMed |
| Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents. Xu W, Chen C, Xu R, Li Y, Hu R, Li Z, Zhu X. Biomed Pharmacother. 2018 Jun;102:587-593. doi: 10.1016/j.biopha.2018.03.098. Epub 2018 Apr 5. PubMed |
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| A rare variant in MLKL confers susceptibility to ApoE varepsilon4-negative Alzheimer's disease in Hong Kong Chinese population. Wang B, Bao S, Zhang Z, Zhou X, Wang J, Fan Y, Zhang Y, Li Y, Chen L, Jia Y, Li J, Li M, Zheng W, Mu N, Wang L, Yu Z, Wong DSM, Zhang Y, Kwan J, Ka-Fung Mak H, Ambalavanan A, Zhou S, Cai W, Zheng J, Huang S, Rouleau GA, Yang W, Rogaeva E, Ma X, St George-Hyslop P, Chu LW, Song YQ. Neurobiol Aging. 2018 Aug;68:160.e1-160.e7. doi: 10.1016/j.neurobiolaging.2018.03.006. Epub 2018 Mar 10. PubMed |
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| Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma. Wang Y, Wong CW, Yan M, Li L, Liu T, Or PM, Tsui SK, Waye MM, Chan AM. Cancer Lett. 2018 Aug 10;429:54-65. doi: 10.1016/j.canlet.2018.04.040. Epub 2018 May 3. PubMed |
| P1 promoter-driven HNF4alpha isoforms are specifically repressed by beta-catenin signaling in colorectal cancer cells. Babeu JP, Jones C, Geha S, Carrier JC, Boudreau F. J Cell Sci. 2018 Jul 6;131(13). pii: jcs.214734. doi: 10.1242/jcs.214734. PubMed |
| Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus. Wu CC, Jiang X, Wang XZ, Liu XJ, Li XJ, Yang B, Ye HQ, Harwardt T, Jiang M, Xia HM, Wang W, Britt WJ, Paulus C, Nevels M, Luo MH. J Virol. 2018 Aug 16;92(17). pii: JVI.00340-18. doi: 10.1128/JVI.00340-18. Print 2018 Sep 1. PubMed |
| The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression. Nikopoulou C, Panagopoulos G, Sianidis G, Psarra E, Ford E, Thanos D. Mol Cell. 2018 Jul 19;71(2):352-361.e5. doi: 10.1016/j.molcel.2018.06.019. Epub 2018 Jul 12. PubMed |
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| Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism. Rakovic A, Domingo A, Grutz K, Kulikovskaja L, Capetian P, Cowley SA, Lenz I, Bruggemann N, Rosales R, Jamora D, Rolfs A, Seibler P, Westenberger A, Konig I, Klein C. Mov Disord. 2018 Jul;33(7):1108-1118. doi: 10.1002/mds.27441. PubMed |
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| NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. Paul S, Ghosh S, Mandal S, Sau S, Pal M. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11. PubMed |
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Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness.
Kim HY, Kim DK, Bae SH, Gwak H, Jeon JH, Kim JK, Lee BI, You HJ, Shin DH, Kim YH, Kim SY, Han SS, Shim JK, Lee JH, Kang SG, Jang H.
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Associated Plasmids |
| Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming. Koutsioumpa M, Hatziapostolou M, Polytarchou C, Tolosa EJ, Almada LL, Mahurkar-Joshi S, Williams J, Tirado-Rodriguez AB, Huerta-Yepez S, Karavias D, Kourea H, Poultsides GA, Struhl K, Dawson DW, Donahue TR, Fernandez-Zapico ME, Iliopoulos D. Gut. 2018 Oct 18. pii: gutjnl-2017-315690. doi: 10.1136/gutjnl-2017-315690. PubMed |
| Neuroendocrine differentiation of prostate cancer leads to PSMA suppression. Bakht MK, Derecichei I, Li Y, Ferraiuolo RM, Dunning M, Oh SW, Hussein A, Youn H, Stringer KF, Jeong CW, Cheon GJ, Kwak C, Kang KW, Lamb AD, Wang Y, Dong X, Porter LA. Endocr Relat Cancer. 2018 Nov 23;26(2):131-146. doi: 10.1530/ERC-18-0226. PubMed |
| The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S. Nature. 2018 Nov;563(7730):265-269. doi: 10.1038/s41586-018-0658-1. Epub 2018 Oct 31. PubMed |
| The nucleosome remodeling and deacetylase complex protein CHD4 regulates neural differentiation of mouse embryonic stem cells by down-regulating p53. Hirota A, Nakajima-Koyama M, Ashida Y, Nishida E. J Biol Chem. 2019 Jan 4;294(1):195-209. doi: 10.1074/jbc.RA118.004086. Epub 2018 Nov 8. PubMed |
| FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer. Li L, Li W, Chen N, Zhao H, Xu G, Zhao Y, Pan X, Zhang X, Zhou L, Yu D, Li A, Hu JF, Cui J. Clin Cancer Res. 2019 Feb 15;25(4):1302-1317. doi: 10.1158/1078-0432.CCR-18-1447. Epub 2018 Nov 14. PubMed |
| GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment. Worley BL, Kim YS, Mardini J, Zaman R, Leon KE, Vallur PG, Nduwumwami A, Warrick JI, Timmins PF, Kesterson JP, Phaeton R, Lee NY, Walter V, Endres L, Mythreye K, Aird KM, Hempel N. Redox Biol. 2018 Nov 17. pii: S2213-2317(18)30891-7. doi: 10.1016/j.redox.2018.11.009. PubMed |
| Cell Death Is Counteracted by Mitophagy in HIV-Productively Infected Astrocytes but Is Promoted by Inflammasome Activation Among Non-productively Infected Cells. Ojeda DS, Grasso D, Urquiza J, Till A, Vaccaro MI, Quarleri J. Front Immunol. 2018 Nov 20;9:2633. doi: 10.3389/fimmu.2018.02633. eCollection 2018. PubMed |
| Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2. Sanin DE, Matsushita M, Klein Geltink RI, Grzes KM, van Teijlingen Bakker N, Corrado M, Kabat AM, Buck MD, Qiu J, Lawless SJ, Cameron AM, Villa M, Baixauli F, Patterson AE, Hassler F, Curtis JD, O'Neill CM, O'Sullivan D, Wu D, Mittler G, Huang SC, Pearce EL, Pearce EJ. Immunity. 2018 Dec 18;49(6):1021-1033.e6. doi: 10.1016/j.immuni.2018.10.011. PubMed |
| IL-8 Secreted from M2 Macrophages Promoted Prostate Tumorigenesis via STAT3/MALAT1 Pathway. Zheng T, Ma G, Tang M, Li Z, Xu R. Int J Mol Sci. 2018 Dec 27;20(1). pii: ijms20010098. doi: 10.3390/ijms20010098. PubMed |
| Common ELF1 deletion in prostate cancer bolsters oncogenic ETS function, inhibits senescence and promotes docetaxel resistance. Budka JA, Ferris MW, Capone MJ, Hollenhorst PC. Genes Cancer. 2018 May;9(5-6):198-214. doi: 10.18632/genesandcancer.182. PubMed |
| SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists. Yang X, Hu Z, Zhang Q, Fan S, Zhong Y, Guo D, Qin Y, Chen M. Cell Discov. 2019 Jan 1;5:1. doi: 10.1038/s41421-018-0068-4. eCollection 2019. PubMed |
| 14-3-3zeta inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling. Song J, Zhang X, Liao Z, Liang H, Chu L, Dong W, Zhang X, Ge Q, Liu Q, Fan P, Zhang Z, Zhang B. J Exp Clin Cancer Res. 2019 Jan 3;38(1):3. doi: 10.1186/s13046-018-1007-9. PubMed |
| Heme oxygenase 1 facilitates cell proliferation via the B-Raf-ERK signaling pathway in melanoma. Liu L, Wu Y, Bian C, Nisar MF, Wang M, Hu X, Diao Q, Nian W, Wang E, Xu W, Zhong JL. Cell Commun Signal. 2019 Jan 11;17(1):3. doi: 10.1186/s12964-018-0313-3. PubMed |
| Exploitation of nuclear protein SFPQ by the encephalomyocarditis virus to facilitate its replication. Zhou B, Wu F, Han J, Qi F, Ni T, Qian F. Biochem Biophys Res Commun. 2019 Feb 26;510(1):65-71. doi: 10.1016/j.bbrc.2019.01.032. Epub 2019 Jan 18. PubMed |
| Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes. Zhao Y, Feng Z, Zhang Y, Sun Y, Chen Y, Liu X, Li S, Zhou T, Chen L, Wei Y, Ma D, Lui KO, Ying H, Chen Y, Ding Q. Cell Rep. 2019 Jan 22;26(4):884-892.e4. doi: 10.1016/j.celrep.2018.12.100. PubMed |
| Enhancer Associated Long Non-coding RNA Transcription and Gene Regulation in Experimental Models of Rickettsial Infection. Chowdhury IH, Narra HP, Sahni A, Khanipov K, Fofanov Y, Sahni SK. Front Immunol. 2019 Jan 9;9:3014. doi: 10.3389/fimmu.2018.03014. eCollection 2018. PubMed |
| Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation. Kim J, Yu L, Chen W, Xu Y, Wu M, Todorova D, Tang Q, Feng B, Jiang L, He J, Chen G, Fu X, Xu Y. Cancer Cell. 2019 Feb 11;35(2):191-203.e8. doi: 10.1016/j.ccell.2018.12.012. Epub 2019 Jan 31. PubMed |
| De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma. Sastre-Perona A, Hoang-Phou S, Leitner MC, Okuniewska M, Meehan S, Schober M. Cell Stem Cell. 2019 Mar 7;24(3):390-404.e8. doi: 10.1016/j.stem.2019.01.003. Epub 2019 Jan 31. PubMed |
| L1 drives IFN in senescent cells and promotes age-associated inflammation. De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beausejour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM. Nature. 2019 Feb;566(7742):73-78. doi: 10.1038/s41586-018-0784-9. Epub 2019 Feb 6. PubMed |
| ETS1 is coexpressed with ZEB2 and mediates ZEB2-induced epithelial-mesenchymal transition in human tumors. Yalim-Camci I, Balcik-Ercin P, Cetin M, Odabas G, Tokay N, Sayan AE, Yagci T. Mol Carcinog. 2019 Jun;58(6):1068-1081. doi: 10.1002/mc.22994. Epub 2019 Mar 6. PubMed |
| ROR1 Expression and Its Functional Significance in Hepatocellular Carcinoma Cells. Cetin M, Odabas G, Douglas LR, Duriez PJ, Balcik-Ercin P, Yalim-Camci I, Sayan AE, Yagci T. Cells. 2019 Mar 2;8(3). pii: cells8030210. doi: 10.3390/cells8030210. PubMed |
| The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways. Xu M, Almasi S, Yang Y, Yan C, Sterea AM, Rizvi Syeda AK, Shen B, Richard Derek C, Huang P, Gujar S, Wang J, Zong WX, Trebak M, El Hiani Y, Dong XP. Cell Calcium. 2019 May;79:80-88. doi: 10.1016/j.ceca.2019.02.010. Epub 2019 Mar 2. PubMed |
| Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling. Jung JW, Macalino SJY, Cui M, Kim JE, Kim HJ, Song DG, Nam SH, Kim S, Choi S, Lee JW. Cell Metab. 2019 Jun 4;29(6):1306-1319.e7. doi: 10.1016/j.cmet.2019.03.005. Epub 2019 Apr 4. PubMed |
WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ.
Nature. 2019 Apr 10. pii: 10.1038/s41586-019-1102-x. doi: 10.1038/s41586-019-1102-x.
PubMed
Associated Plasmids |
| Genome-wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth. Wang Y, Gao B, Tan PY, Handoko YA, Sekar K, Deivasigamani A, Seshachalam VP, OuYang HY, Shi M, Xie C, Goh BKP, Ooi LL, Man Hui K. FASEB J. 2019 Aug;33(8):8759-8770. doi: 10.1096/fj.201802213RR. Epub 2019 Apr 25. PubMed |
| Wnt signaling regulates cytosolic translocation of connexin 43. Hou X, Khan MRA, Turmaine M, Thrasivoulou C, Becker DL, Ahmed A. Am J Physiol Regul Integr Comp Physiol. 2019 Aug 1;317(2):R248-R261. doi: 10.1152/ajpregu.00268.2018. Epub 2019 May 8. PubMed |
| APPBP2 enhances non-small cell lung cancer proliferation and invasiveness through regulating PPM1D and SPOP. Gong H, Liu F, Liu X, Min S, Wu N, Liu X, Liu Y, Han S, Zhang Y, Zhang Y, Hu Y, Liu X, Wang X. EBioMedicine. 2019 Jun;44:138-149. doi: 10.1016/j.ebiom.2019.05.028. Epub 2019 May 16. PubMed |
| Genome-wide target interactome profiling reveals a novel EEF1A1 epigenetic pathway for oncogenic lncRNA MALAT1 in breast cancer. Li X, Chen N, Zhou L, Wang C, Wen X, Jia L, Cui J, Hoffman AR, Hu JF, Li W. Am J Cancer Res. 2019 Apr 1;9(4):714-729. eCollection 2019. PubMed |
| MicroRNA-200b is downregulated and suppresses metastasis by targeting LAMA4 in renal cell carcinoma. Li Y, Guan B, Liu J, Zhang Z, He S, Zhan Y, Su B, Han H, Zhang X, Wang B, Li X, Zhou L, Zhao W. EBioMedicine. 2019 Jun;44:439-451. doi: 10.1016/j.ebiom.2019.05.041. Epub 2019 May 23. PubMed |
| Discovery of a Pathogenic Variant rs139379666 (p. P2974L) in ATM for Breast Cancer Risk in Chinese Populations. Guo X, Lin W, Bai M, Li H, Wen W, Zeng C, Chen Z, He J, Chen J, Cai Q, Long J, Jia WH, Shu XO, Zheng W. Cancer Epidemiol Biomarkers Prev. 2019 Aug;28(8):1308-1315. doi: 10.1158/1055-9965.EPI-18-1294. Epub 2019 Jun 3. PubMed |
| Hsp105alpha suppresses Adriamycin-induced cell death via nuclear localization signal-dependent nuclear accumulation. Yamane T, Saito Y, Teshima H, Hagino M, Kakihana A, Sato S, Shimada M, Kato Y, Kuga T, Yamagishi N, Nakayama Y. J Cell Biochem. 2019 Jun 7. doi: 10.1002/jcb.29062. PubMed |
| Abundance of d-2-hydroxyglutarate in G2/M is determined by FOXM1 in mutant IDH1-expressing cells. Bala Bhaskara Rao K, Katragunta K, Sarma UM, Jain N. FEBS Lett. 2019 Jun 18. doi: 10.1002/1873-3468.13500. PubMed |
| The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity. Peng H, Yang F, Hu Q, Sun J, Peng C, Zhao Y, Huang C. Autophagy. 2020 Apr;16(4):698-708. doi: 10.1080/15548627.2019.1635381. Epub 2019 Jul 1. PubMed |
| CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction. Yeung YT, Fan S, Lu B, Yin S, Yang S, Nie W, Wang M, Zhou L, Li T, Li X, Bode AM, Dong Z. Carcinogenesis. 2019 Jun 25. pii: 5523300. doi: 10.1093/carcin/bgz113. PubMed |
| DAPLE and MPDZ bind to each other and cooperate to promote apical cell constriction. Marivin A, Garcia-Marcos M. Mol Biol Cell. 2019 Jul 22;30(16):1900-1910. doi: 10.1091/mbc.E19-02-0091. Epub 2019 Jul 3. PubMed |
| Porphyromonas gingivalis-derived lipopolysaccharide causes excessive hepatic lipid accumulation via activating NF-kappaB and JNK signaling pathways. Ding LY, Liang LZ, Zhao YX, Yang YN, Liu F, Ding QR, Luo LJ. Oral Dis. 2019 Oct;25(7):1789-1797. doi: 10.1111/odi.13153. Epub 2019 Jul 28. PubMed |
| In silico analysis-based identification of the target residue of integrin alpha6 for metastasis inhibition of basal-like breast cancer. Tanaka S, Senda N, Iida A, Sehara-Fujisawa A, Ishii T, Sato F, Toi M, Itou J. Genes Cells. 2019 Sep;24(9):596-607. doi: 10.1111/gtc.12714. Epub 2019 Aug 5. PubMed |
| microRNA-183-3p Inhibits Progression of Human Prostate Cancer by Downregulating High-Mobility Group Nucleosome Binding Domain 5. Li Y, He S, Zhan Y, He A, Gong Y, Ji G, Huang C, Peng D, Guan B, Li X, Zhou L. DNA Cell Biol. 2019 Aug;38(8):840-848. doi: 10.1089/dna.2019.4642. Epub 2019 Jul 17. PubMed |
| Induced pluripotent stem cell generation from bovine somatic cells indicates unmet needs for pluripotency sustenance. Pillai VV, Kei TG, Reddy SE, Das M, Abratte C, Cheong SH, Selvaraj V. Anim Sci J. 2019 Sep;90(9):1149-1160. doi: 10.1111/asj.13272. Epub 2019 Jul 19. PubMed |
| Mitochondria Are Dynamically Transferring Between Human Neural Cells and Alexander Disease-Associated GFAP Mutations Impair the Astrocytic Transfer. Gao L, Zhang Z, Lu J, Pei G. Front Cell Neurosci. 2019 Jul 10;13:316. doi: 10.3389/fncel.2019.00316. eCollection 2019. PubMed |
| Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area. Zhao R, Afthinos A, Zhu T, Mistriotis P, Li Y, Serra SA, Zhang Y, Yankaskas CL, He S, Valverde MA, Sun SX, Konstantopoulos K. Sci Adv. 2019 Jul 24;5(7):eaaw7243. doi: 10.1126/sciadv.aaw7243. eCollection 2019 Jul. PubMed |
| The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Hennessy EJ, van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, Caffrey BE, Hussein MA, Ricci EP, Temel RE, Garabedian MJ, Berger JS, Vickers KC, Kanke M, Sethupathy P, Teupser D, Holdt LM, Moore KJ. Nat Metab. 2019 Jan;1(1):98-110. doi: 10.1038/s42255-018-0004-9. Epub 2018 Dec 3. PubMed |
| Mitochondrial calcium uniporter regulates PGC-1alpha expression to mediate metabolic reprogramming in pulmonary fibrosis. Gu L, Larson Casey JL, Andrabi SA, Lee JH, Meza-Perez S, Randall TD, Carter AB. Redox Biol. 2019 Sep;26:101307. doi: 10.1016/j.redox.2019.101307. Epub 2019 Aug 25. PubMed |
| CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKCepsilon activation and phosphorylation of XIAP. Baek HS, Kwon YJ, Ye DJ, Cho E, Kwon TU, Chun YJ. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118553. doi: 10.1016/j.bbamcr.2019.118553. Epub 2019 Sep 4. PubMed |
| TRP14 promotes resistance to cisplatin by inducing autophagy in ovarian cancer. Tan WX, Xu TM, Zhou ZL, Lv XJ, Liu J, Zhang WJ, Cui MH. Oncol Rep. 2019 Aug 2. doi: 10.3892/or.2019.7258. PubMed |
| The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nguyen TM, Kabotyanski EB, Reineke LC, Shao J, Xiong F, Lee JH, Dubrulle J, Johnson H, Stossi F, Tsoi PS, Choi KJ, Ellis AG, Zhao N, Cao J, Adewunmi O, Ferreon JC, Ferreon ACM, Neilson JR, Mancini MA, Chen X, Kim J, Ma L, Li W, Rosen JM. Nucleic Acids Res. 2020 Mar 18;48(5):2621-2642. doi: 10.1093/nar/gkz1176. PubMed |
| Huntington's Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy. Fox LM, Kim K, Johnson CW, Chen S, Croce KR, Victor MB, Eenjes E, Bosco JR, Randolph LK, Dragatsis I, Dragich JM, Yoo AS, Yamamoto A. Neuron. 2020 Mar 4;105(5):813-821.e6. doi: 10.1016/j.neuron.2019.12.003. Epub 2019 Dec 30. PubMed |
| SOX9 promotes tumor progression through the axis BMI1-p21(CIP). Aldaz P, Otaegi-Ugartemendia M, Saenz-Antonanzas A, Garcia-Puga M, Moreno-Valladares M, Flores JM, Gerovska D, Arauzo-Bravo MJ, Sampron N, Matheu A, Carrasco-Garcia E. Sci Rep. 2020 Jan 15;10(1):357. doi: 10.1038/s41598-019-57047-w. PubMed |
| p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids. Marin Navarro A, Pronk RJ, van der Geest AT, Oliynyk G, Nordgren A, Arsenian-Henriksson M, Falk A, Wilhelm M. Cell Death Dis. 2020 Jan 23;11(1):52. doi: 10.1038/s41419-019-2208-7. PubMed |
| Targeting the EphB4 receptor tyrosine kinase sensitizes HER2-positive breast cancer cells to Lapatinib. Ding J, Yao Y, Huang G, Wang X, Yi J, Zhang N, Liu C, Wang K, Zhang Y, Wang M, Liu P, Ye M, Li M, Cheng H. Cancer Lett. 2020 Apr 10;475:53-64. doi: 10.1016/j.canlet.2020.01.032. Epub 2020 Jan 29. PubMed |
| MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing. Yu L, Kim J, Jiang L, Feng B, Ying Y, Ji KY, Tang Q, Chen W, Mai T, Dou W, Zhou J, Xiang LY, He YF, Yang D, Li Q, Fu X, Xu Y. Nat Commun. 2020 Feb 5;11(1):708. doi: 10.1038/s41467-020-14437-3. PubMed |
| A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells. Guo L, Li J, Zeng H, Guzman AG, Li T, Lee M, Zhou Y, Goodell MA, Stephan C, Davies PJA, Dawson MA, Sun D, Huang Y. Nat Commun. 2020 Feb 6;11(1):740. doi: 10.1038/s41467-020-14604-6. PubMed |
| Mutant GTF2I induces cell transformation and metabolic alterations in thymic epithelial cells. Kim IK, Rao G, Zhao X, Fan R, Avantaggiati ML, Wang Y, Zhang YW, Giaccone G. Cell Death Differ. 2020 Jul;27(7):2263-2279. doi: 10.1038/s41418-020-0502-7. Epub 2020 Feb 7. PubMed |
| NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer. Zhou L, Wang D, Sheng D, Xu J, Chen W, Qin Y, Du R, Yang X, He X, Xie N, Liu S, Zhang L. Theranostics. 2020 Jan 19;10(5):2405-2421. doi: 10.7150/thno.38875. eCollection 2020. PubMed |
| Ligand-dependent internalization of Bombyx mori tachykinin-related peptide receptor is regulated by PKC, GRK5 and beta-arrestin2/BmKurtz. He X, Yan L, Wu Q, Zhang G, Zhou N. Biochim Biophys Acta Mol Cell Res. 2020 Jun;1867(6):118690. doi: 10.1016/j.bbamcr.2020.118690. Epub 2020 Feb 26. PubMed |
| YWHAE/14-3-3epsilon expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma. Xu Y, Fulciniti M, Samur MK, Ho M, Deng S, Liu L, Wen K, Yu T, Chyra Z, Dereibal S, Zhang L, Yao Y, Chakraborty C, Morelli E, Li N, Lopez MA, Perini T, Mu S, An G, Alonso R, Bianchi G, Tai YT, Anderson KC, Qiu L, Munshi NC. Blood. 2020 Jul 23;136(4):468-479. doi: 10.1182/blood.2019004147. PubMed |
| Irreversible JNK1-JUN inhibition by JNK-IN-8 sensitizes pancreatic cancer to 5-FU/FOLFOX chemotherapy. Lipner MB, Peng XL, Jin C, Xu Y, Gao Y, East MP, Rashid NU, Moffitt RA, Herrera Loeza SG, Morrison AB, Golitz BT, Vaziri C, Graves LM, Johnson GL, Yeh JJ. JCI Insight. 2020 Apr 23;5(8). pii: 129905. doi: 10.1172/jci.insight.129905. PubMed |
| p75NTR(-/-) mice exhibit an alveolar bone loss phenotype and inhibited PI3K/Akt/beta-catenin pathway. Wang Y, Yang K, Li G, Liu R, Liu J, Li J, Tang M, Zhao M, Song J, Wen X. Cell Prolif. 2020 Apr;53(4):e12800. doi: 10.1111/cpr.12800. Epub 2020 Mar 25. PubMed |
| Ketamine promotes the neural differentiation of mouse embryonic stem cells by activating mTOR. Zhou X, Lv X, Zhang L, Yan J, Hu R, Sun Y, Xi S, Jiang H. Mol Med Rep. 2020 Jun;21(6):2443-2451. doi: 10.3892/mmr.2020.11043. Epub 2020 Mar 30. PubMed |
| Midkine signaling maintains the self-renewal and tumorigenic capacity of glioma initiating cells. Lopez-Valero I, Davila D, Gonzalez-Martinez J, Salvador-Tormo N, Lorente M, Saiz-Ladera C, Torres S, Gabicagogeascoa E, Hernandez-Tiedra S, Garcia-Taboada E, Mendiburu-Elicabe M, Rodriguez-Fornes F, Sanchez-Dominguez R, Segovia JC, Sanchez-Gomez P, Matheu A, Sepulveda JM, Velasco G. Theranostics. 2020 Apr 6;10(11):5120-5136. doi: 10.7150/thno.41450. eCollection 2020. PubMed |
| LncRNA BCAR4 promotes liver cancer progression by upregulating ANAPC11 expression through sponging miR1261. Zhang Y, Zhou H. Int J Mol Med. 2020 Jul;46(1):159-166. doi: 10.3892/ijmm.2020.4586. Epub 2020 Apr 22. PubMed |
| Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation. Adjibade P, Simoneau B, Ledoux N, Gauthier WN, Nkurunziza M, Khandjian EW, Mazroui R. PLoS One. 2020 May 4;15(5):e0231894. doi: 10.1371/journal.pone.0231894. eCollection 2020. PubMed |
| m(6) A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis. Nagaki Y, Motoyama S, Yamaguchi T, Hoshizaki M, Sato Y, Sato T, Koizumi Y, Wakita A, Kawakita Y, Imai K, Nanjo H, Watanabe H, Imai Y, Minamiya Y, Kuba K. Genes Cells. 2020 May 25. doi: 10.1111/gtc.12792. PubMed |
| The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Millar R, Kilbey A, Remak SJ, Severson TM, Dhayade S, Sandilands E, Foster K, Bryant DM, Blyth K, Coffelt SB. Mol Oncol. 2020 Aug;14(8):1868-1880. doi: 10.1002/1878-0261.12734. Epub 2020 Jun 17. PubMed |
| Androgen receptor-induced integrin alpha6beta1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer. Nollet EA, Cardo-Vila M, Ganguly SS, Tran JD, Schulz VV, Cress A, Corey E, Miranti CK. Oncogene. 2020 Jul;39(31):5390-5404. doi: 10.1038/s41388-020-1370-9. Epub 2020 Jun 21. PubMed |
| NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Miao K, Lei JH, Valecha MV, Zhang A, Xu J, Wang L, Lyu X, Chen S, Miao Z, Zhang X, Su SM, Shao F, Rajendran BK, Bao J, Zeng J, Sun H, Chen P, Tan K, Chen Q, Wong KH, Xu X, Deng CX. Nat Commun. 2020 Jun 26;11(1):3256. doi: 10.1038/s41467-020-16936-9. PubMed |
| SRF-MRTF signaling suppresses brown adipocyte development by modulating TGF-beta/BMP pathway. Liu R, Xiong X, Nam D, Yechoor V, Ma K. Mol Cell Endocrinol. 2020 Jun 27:110920. doi: 10.1016/j.mce.2020.110920. PubMed |
| EXO1 Plays a Carcinogenic Role in Hepatocellular Carcinoma and is related to the regulation of FOXP3. Yang G, Dong K, Zhang Z, Zhang E, Liang B, Chen X, Huang Z. J Cancer. 2020 Jun 16;11(16):4917-4932. doi: 10.7150/jca.40673. eCollection 2020. PubMed |
| Dorsoventral polarity directs cell responses to migration track geometries. Wisniewski EO, Mistriotis P, Bera K, Law RA, Zhang J, Nikolic M, Weiger M, Parlani M, Tuntithavornwat S, Afthinos A, Zhao R, Wirtz D, Kalab P, Scarcelli G, Friedl P, Konstantopoulos K. Sci Adv. 2020 Jul 31;6(31):eaba6505. doi: 10.1126/sciadv.aba6505. eCollection 2020 Jul. PubMed |
| Sequestosome 1 (p62) accumulation in breast cancer cells suppresses progesterone receptor expression via argonaute 2. Yokota A, Hiramoto M, Hino H, Tokuhisa M, Miyazaki M, Kazama H, Takano N, Miyazawa K. Biochem Biophys Res Commun. 2020 Oct 15;531(2):256-263. doi: 10.1016/j.bbrc.2020.07.058. Epub 2020 Aug 13. PubMed |
| Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs. Cates K, McCoy MJ, Kwon JS, Liu Y, Abernathy DG, Zhang B, Liu S, Gontarz P, Kim WK, Chen S, Kong W, Ho JN, Burbach KF, Gabel HW, Morris SA, Yoo AS. Cell Stem Cell. 2021 Jan 7;28(1):127-140.e9. doi: 10.1016/j.stem.2020.08.015. Epub 2020 Sep 21. PubMed |
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Isoforms of the TAL1 transcription factor have different roles in hematopoiesis and cell growth.
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| Small Extracellular Vesicle-Derived vWF Induces a Positive Feedback Loop between Tumor and Endothelial Cells to Promote Angiogenesis and Metastasis in Hepatocellular Carcinoma. Wong SWK, Tey SK, Mao X, Fung HL, Xiao ZJ, Wong DKH, Mak LY, Yuen MF, Ng IO, Yun JP, Gao Y, Yam JWP. Adv Sci (Weinh). 2023 Sep;10(26):e2302677. doi: 10.1002/advs.202302677. Epub 2023 Jun 30. PubMed |
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NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.
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| An EBV-related CD4 TCR immunotherapy inhibits tumor growth in an HLA-DP5+ nasopharyngeal cancer mouse model. Wang C, Chen J, Li J, Xu Z, Huang L, Zhao Q, Chen L, Liang X, Hu H, Li G, Xiong C, Wu B, You H, Du D, Wang X, Li H, Wang Z, Chen L. J Clin Invest. 2024 Feb 27;134(8):e172092. doi: 10.1172/JCI172092. PubMed |
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