...look far for proof that this model of public involvement, research, and consensus can happen. We just ...funded a center for mitochondrial research to investigate the scientific possibility, safety, and efficacy...efficacy of the mtDNA transfer options being investigated; A UK regulatory body tasked two separate non-governmental...

...for PZA-resistant Mycobacteria tuberculosis. Investigation of multispecies biofilm formed by Pseudomonas...compounds on these proteins will be tested. Investigating changes in neuronal activity after ischemic ...Armenia Gohar Tsakanova is a Senior Researcher who investigates the molecular and cellular etiopathomechanisms...

...impacted by a project. Instead, invite the experts on the topic at hand. Invite one “ambassador” from each ...clarification - new and useful information, and invigoration - a renewed energy for continuing the project...

...to make sure the work gets done and done well. Involving your team effectively is now your new measure ...creative thinking. The team members will be more invested in the projects and outcomes. The quality of ...you and you must usually take on all tasks that involve confidential information. No matter who you delegate...

...service in 2016, we’ve added many new tools to our inventory of ready-to-use viral vectors. Here are some of...interneurons (83895). See our Serotype Testing AAV inventory for the entire collection! Plasmid Serotype...Fishell   Chemogenetics Chemogenetics offers noninvasive methods for manipulating cell activity, particularly...

... than one?   Multiplex assays Multiplex assays involve multiple antibodies, each with a different signaling...of your fluorophores before buying and try to inversely pair brightness with abundance whenever possible...possible.      Fig 2: Try to inversely pair fluorophore strength with protein abundance.    Second...

...vector, L4440, places a target gene between two inverted T7 promoters. Transcription from each promoter...Src homology 3 (SH3) domain family, known to be involved in cytoskeletal control, cell growth, and endocytosis...carry out any biochemical and biophysical study involving protein stability or binding experiments. Potential...

...Library, deposited by Carrie Bhang, a research investigator in the In Vivo Pharmacology group at Novartis...ClonTracer Since starting her new role as an investigator in the In Vivo Pharmacology group at Novartis...Addgene community! Carrie Bhang is a research investigator in In Vivo Pharmacology at Novartis Oncology...

...therapies from conceptual design to clinical trials involve identifying a therapeutic gene, finding a means...variety of vector delivery technologies have been investigated including lentiviruses, adenovirus, and inorganic...Ken Y., et al. "Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous...

...a popular tool in the field as it provides a noninvasive method for manipulating cell activity, especially...provided by chemogenetics are instead that it is noninvasive and has longer-lasting effects. Building your...specific circuits. Methods for targeting expression involve tissue specific promoters, AAV serotypes, and the...

...heritable changes in gene expression that do not involve any changes to DNA sequence (Epigenetics literally... can present without any DNA changes, and both involve the same region of chromosome 15. They both result...positions on histone H3, which are known to be involved in repression and X-inactivation. The K9 reporter...

... lead to a wealth of additional experiments investigating the role of individual genes or entire pathways...a population of mutant cells to identify genes involved in a particular phenotype. CRISPR can be readily...specific classes of human genes. What are the steps involved in a CRISPR screen? Performing a forward genetic...

... this interrogation process, they will almost invariably say something like “Oh,…I didn’t quite appreciate...educators introduce their students to this otherwise invisible molecular world. For the students, the models ...creating physical models of proteins that are being investigated in their labs. Soon after we began working with...

...which are known to be a part of an organelle or involved in intracellular transport pathways, it is possible...direct molecular interaction without further investigation. One fluorescent microscopy method commonly ...useful for your next localization experiment and invite you to make any fluorescent protein constructs ...

...Gräslund lab. Recent findings suggest that aaRSs are involved in inflammation and autoimmune diseases, so these...within a multi-tRNA synthetase complex, the team investigated whether the generated antibodies could bind ...INTRSECT viral preps available! We are expanding our inventory of ready to use viral preps from the Deisseroth...

...Pelham’s first published peptide tagging experiment involved a peptide from the neuropeptide substance P. This...suitable pair for protein tagging. In two studies investigating mechanisms of endoplasmic reticulum localization...versions of Myc1-9E10 mentioned above basically involve taking the Myc1-9E10 variable regions and sticking...

...by meeting with professors - a/k/a Principle Investigators (PIs) - whose labs does research that aligns... receiving applications, universities typically invite a select group of students to continue the application...accessible, inclusive, and accommodating for everyone involved in the process. COVID-19 has changed many aspects...

... you understand the perspective of all persons involved and be used as a guide to point you toward a creative...third example shows, the ultimate resolution can involve ideas not related to the actual data collection... How can I negotiate to show the company that investing in me is also beneficial to them? I have an idea...

...discovery: Unless your academic lab is closely involved with clinical trials or has ties to industry, ...work. The number of steps, decisions and people involved is staggering. The process is complicated. If ...important to you, make sure that your project will not involve proprietary compounds or information. Where publication...

... don't have good ways of converting typically invisible information into actionable signals. Let's say...sensors. Those sensors could transduce otherwise invisible molecules into regulation of gene expression including...bioeconomy, and that it’s been 40 years since the invention of genetic engineering. What's incredible is the...