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Showing: 61 - 80 of 149 results

  2. New Optogenetic Tools for Cytoskeleton and Membrane Control

    Type
    Blog Post
    Published
    Sept. 28, 2023, 1:15 p.m.
    ...and more, often driven by Rho family signaling pathways. Rho guanine-nucleotide exchange factors (GEFs...phosphatidic acid signaling (such as Hippo, AMPK and mTOR pathways) and to introduce unnatural head groups for applications...

  3. 3 Tips to Improve HDR Efficiency for CRISPR Editing in Human Cells

    Type
    Blog Post
    Published
    Sept. 5, 2017, 1:58 p.m.
    ...repaired by the nonhomologous end-joining (NHEJ) pathway, leading to nonspecific nucleotide insertions, ...homology-directed repair (HDR), a distinct cellular DNA repair pathway. Accomplishing this usually involves simultaneously...

  4. Treating Muscular Dystrophy with CRISPR Gene Editing

    Type
    Blog Post
    Published
    Jan. 26, 2016, 3:30 p.m.
    ...genome editing. The homology-directed repair (HDR) pathway is downregulated in mature tissues - no problem... through the non-homologous end joining (NHEJ) pathway. It’s estimated that very little dystrophin correction...

  6. Cancer and the Immune System: Deciphering the Relationship

    Type
    Blog Post
    Published
    March 14, 2017, 2:30 p.m.
    ...approved monoclonal antibodies targeting the PD-L1 pathway, VEGF production, and CTLA4 and CD protein blocking...Research Cancer Drug Resistance Checkout the RAS Pathway Clone Collection ...

  7. Antibodies 101: Introduction to Antibodies

    Type
    Blog Post
    Published
    Jan. 19, 2021, 2:15 p.m.
    ...body, or they can be used to activate cellular pathways by binding to cell surface receptors. These applications...are typically used for investigating signaling pathways or developing therapeutics. Experimentally, antibodies...

  9. CRISPR 101: Cytosine and Adenine Base Editors

    Type
    Blog Post
    Published
    Feb. 13, 2025, 2:15 p.m.
    ...efficiency of homology-directed repair (HDR), the pathway for resolving DNA double-strand breaks (DSBs) preferred..., P., Lee, K. D., Ortega, M. A., Sawyer, C., Schwaegerle, N. D., Peraro, L., Young, L., Lee, S.-J., Ciaramella...

  10. Designer PUF Proteins for Any RNA Target

    Type
    Blog Post
    Published
    June 17, 2014, 7:57 p.m.
    ...use in basic biology, for example, by targeting pathways underlying cancer or other disease processes. ...

  18. Antibodies 101: Fc Effector Functions

    Type
    Blog Post
    Published
    May 18, 2023, 1:15 p.m.
    ...activates the immune system's classical complement pathway, starting a cascade of events that results in the...

  20. Advice for Choosing a Research Project

    Type
    Blog Post
    Published
    April 17, 2014, 2:45 p.m.
    ...to follow the design, execute, analyze, repeat pathway that is required of scientists.” Professor George...
Showing: 61 - 80 of 149 results