Addgene

We narrowed to 156,904 results for: addgene

Showing: 81 - 100 of 156904 results

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Human Metabolic Gene CRISPRa sgRNA library

Pooled Library

#187080

Purpose

Lentiviral CRISPRa library targeting human metabolic genes for activation of gene expression

Depositor

Kivanc Birsoy

Article

Unlu et al Mol Cell. 2022 Aug 4;82(15):2832-2843.e7

Expression

Mammalian

Species

Homo sapiens

Use

Lentiviral

Available since

Oct. 26, 2022

Availability

Academic Institutions and Nonprofits only
Inzolia library in pRDA_052

Pooled Library

#209551

Purpose

The human, genome-wide, CRISPR knockout enAsCas12a gRNA library targets single genes and paralog pairs, triples, and quads with arrays of 4 gRNAs.

Depositor

John Doench

Article

Esmaeili Anvar et al Nat Commun. 2024 Apr 27;15(1):3577. doi:

Use

CRISPR and Lentiviral

Available since

Dec. 5, 2023

Availability

Academic Institutions and Nonprofits only
Mouse Metabolic Gene CRISPRa sgRNA library

Pooled Library

#187081

Purpose

Lentiviral CRISPRa library targeting mouse metabolic genes for activation of gene expression

Depositor

Kivanc Birsoy

Article

Unlu et al Mol Cell. 2022 Aug 4;82(15):2832-2843.e7

Expression

Mammalian

Species

Mus musculus

Use

Lentiviral

Available since

Oct. 26, 2022

Availability

Academic Institutions and Nonprofits only
Inzolia library in pRDA_550

Pooled Library

#209552

Purpose

The human, genome-wide, CRISPR knockout enAsCas12a gRNA library targets single genes and paralog pairs, triples, and quads with arrays of 4 gRNAs.

Depositor

John Doench

Article

Esmaeili Anvar et al Nat Commun. 2024 Apr 27;15(1):3577. doi:

Use

CRISPR and Lentiviral

Available since

Dec. 5, 2023

Availability

Academic Institutions and Nonprofits only
Humagne Set C

Pooled Library

#172650

Purpose

Set C contains best-ranked guides 1 and 4.

Depositor

David Root, John Doench

Article

DeWeirdt et al Nat Biotechnol. 2020 Jul 13. pii: 10.103

Expression

Mammalian

Available since

Nov. 10, 2021

Availability

Academic Institutions and Nonprofits only
Humagne Set D

Pooled Library

#172651

Purpose

Set D contains best-ranked guides 2 and 3.

Depositor

David Root, John Doench

Article

DeWeirdt et al Nat Biotechnol. 2020 Jul 13. pii: 10.103

Expression

Mammalian

Available since

Nov. 10, 2021

Availability

Academic Institutions and Nonprofits only
Lourido Toxoplasma CRISPR Library V1

Pooled Library

#80636

Purpose

Plasmid sgRNA library containing ten guides against each of the 8,158 predicted Toxoplasma gondii protein coding genes.

Depositor

Sebastian Lourido

Article

Sidik et al Cell. 2016 Sep 8;166(6):1423-1435.e12. d

Available since

Sept. 19, 2016

Availability

Academic Institutions and Nonprofits only
EFS-mTSG

Pooled Library

#113584

Purpose

AAV-CRISPR library for pool mutagenesis of top tumor suppressor genes

Depositor

Sidi Chen

Article

Wang et al Sci Adv. 2018 Feb 28;4(2):eaao5508. doi:

Expression

Mammalian

Use

AAV, CRISPR, Lentiviral, and Luciferase

Available since

July 23, 2019

Availability

Academic Institutions and Nonprofits only
mTORC1 Focused library

Pooled Library

#164084

Purpose

Lentiviral CRISPR library targets human mTORC1 signaling pathway

Depositor

David Sabatini

Article

Condon et al Proc Natl Acad Sci U S A. 2021 Jan 26;11

Expression

Mammalian

Species

Homo sapiens

Use

CRISPR and Lentiviral

Available since

Jan. 11, 2021

Availability

Academic Institutions and Nonprofits only
Oxford Drosophila melanogaster Genome-wide CRISPR Library

Pooled Library

#64750

Purpose

A genome-wide CRISPR library covering 13,501 genes (98.8% of the Drosophila melanogaster genome), among which 8,989 genes are targeted by three or more independent single guide RNAs (sgRNAs).

Depositor

Ji-Long Liu

Article

Bassett et al J Genet Genomics. 2015 Jun 20;42(6):301-

Expression

Insect

Species

Drosophila melanogaster, Streptococcus pyogenes, and Synthetic

Use

CRISPR

Available since

March 7, 2016

Availability

Academic Institutions and Nonprofits only
DNA repair library with 336 sgRNAs

Pooled Library

#177664

Purpose

CRISPR-interference (CRISPRi) library of 366 sgRNAs targeting 118 genes encoding factors involved in DNA repair and associated processes

Depositor

Brittany Adamson

Article

Hussmann et al Cell. 2021 Oct 28;184(22):5653-5669.e25.

Species

Homo sapiens

Use

CRISPR

Available since

Nov. 29, 2023

Availability

Academic Institutions and Nonprofits only
mU6-CR1-CRISPRiv2_hU6-CR3-NT-ctrl-guide_EF1a-PuroR-T2A-BFP

Pooled Library

#197348

Purpose

To allow for genome-wide genetic modifier screening, the library has a second fixed non-targeting control guide.

Depositor

Jonathan Weissman, Rebecca Voorhees

Article

Guna et al BMC Genomics. 2023 Oct 30;24(1):651. doi

Species

Homo sapiens

Use

Lentiviral

Available since

May 25, 2023

Availability

Academic Institutions and Nonprofits only
RNA-binding protein pooled CRISPR knockout library

Pooled Library

#141438

Purpose

CRISPR knockout library targets RBPs with 10 sgRNAs/gene

Depositor

Eugene Yeo

Article

Wheeler et al Nat Methods. 2020 May 11. pii: 10.1038/s

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

May 28, 2020

Availability

Academic Institutions and Nonprofits only
The Human Druggable CRISPR library

Pooled Library

#200013

Purpose

The library contains ~10,000 sgRNAs targeting 1,980 human genes (5 sgRNAs per gene and 100 nontargeting control sgRNAs).

Depositor

Lianxin Liu

Article

Zheng et al Adv Sci (Weinh). 2023 Aug;10(22):e220679

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

May 9, 2023

Availability

Academic Institutions and Nonprofits only
Human SLC overexpression library

Pooled Library

#213694

Purpose

Inducible barcoded library with 467 codon-optimized cDNAs with UMIs to test the impact of SLC transporters on biological processes.

Depositor

Giulio Superti-Furga, RESOLUTE Consortium

Article

Wolf et al Cell Chem Biol. 2024 Dec 24:S2451-9456(2

Expression

Mammalian

Species

Homo sapiens

Use

Lentiviral

Available since

Aug. 30, 2024

Availability

Academic Institutions and Nonprofits only
Perturb-seq GBC library

Pooled Library

#85968

Purpose

Perturb-seq GBC library

Depositor

Jonathan Weissman

Article

Adamson et al Cell. 2016 Dec 15;167(7):1867-1882.e21.

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

Feb. 14, 2017

Availability

Academic Institutions and Nonprofits only
TBG-mTSG

Pooled Library

#113585

Purpose

AAV-CRISPR library for pool mutagenesis of top tumor suppressor genes in mouse liver

Depositor

Sidi Chen

Article

Wang et al Sci Adv. 2018 Feb 28;4(2):eaao5508. doi:

Expression

Mammalian

Use

AAV, CRISPR, Lentiviral, and Luciferase

Available since

July 23, 2019

Availability

Academic Institutions and Nonprofits only
Human sgRNA library Brunello in lentiCRISPRv2

Pooled Library

#73179

Purpose

Human sgRNA library in backbone lentiCRISPRv2 targeting 19,114 genes and containing 76,441 unique sgRNAs along with 1000 non-targeting controls

Depositor

David Root, John Doench

Article

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Has Service

Lentiviral Prep

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

Feb. 9, 2016

Availability

Academic Institutions and Nonprofits only
Human sgRNA library Brunello in lentiGuide-Puro

Pooled Library

#73178

Purpose

Human sgRNA library in backbone lentiGuide-Puro targeting 19,114 genes and containing 76,441 unique sgRNAs along with 1000 non-targeting controls

Depositor

David Root, John Doench

Article

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Has Service

Lentiviral Prep

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

Feb. 9, 2016

Availability

Academic Institutions and Nonprofits only
Mouse sgRNA library Brie in lentiGuide-Puro

Pooled Library

#73633

Purpose

Mouse sgRNA library in backbone lentiGuide-Puro containing 78,637 unique sgRNAs targeting 19,674 genes along with 1000 non-targeting controls

Depositor

David Root, John Doench

Article

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Has Service

Lentiviral Prep

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

Feb. 25, 2016

Availability

Academic Institutions and Nonprofits only

Showing: 81 - 100 of 156904 results

Results per page:

Sort results by:

Human Metabolic Gene CRISPRa sgRNA library

Inzolia library in pRDA_052

Mouse Metabolic Gene CRISPRa sgRNA library

Inzolia library in pRDA_550

Humagne Set C

Humagne Set D

Lourido Toxoplasma CRISPR Library V1

EFS-mTSG

mTORC1 Focused library

Oxford Drosophila melanogaster Genome-wide CRISPR Library

DNA repair library with 336 sgRNAs

mU6-CR1-CRISPRiv2_hU6-CR3-NT-ctrl-guide_EF1a-PuroR-T2A-BFP

RNA-binding protein pooled CRISPR knockout library

The Human Druggable CRISPR library

Human SLC overexpression library

Perturb-seq GBC library

TBG-mTSG

Human sgRNA library Brunello in lentiCRISPRv2

Human sgRNA library Brunello in lentiGuide-Puro

Mouse sgRNA library Brie in lentiGuide-Puro

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