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Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction.

Condon KJ, Orozco JM, Adelmann CH, Spinelli JB, van der Helm PW, Roberts JM, Kunchok T, Sabatini DM
Proc Natl Acad Sci U S A. 2021 Jan 26;118(4). pii: 2022120118. doi: 10.1073/pnas.2022120118. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
164076pCW57.kc1-HSD17B10Human codon optimized HSD17B10. Expression is controlled by doxycycline.
164084mTORC1 Focused libraryLentiviral CRISPR library targets human mTORC1 signaling pathway

Antibodies from Article