Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction.
Condon KJ, Orozco JM, Adelmann CH, Spinelli JB, van der Helm PW, Roberts JM, Kunchok T, Sabatini DM
Proc Natl Acad Sci U S A. 2021 Jan 26;118(4). pii: 2022120118. doi: 10.1073/pnas.2022120118.
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Plasmids from Article
ID | Plasmid | Purpose |
---|---|---|
164076 | pCW57.kc1-HSD17B10 | Human codon optimized HSD17B10. Expression is controlled by doxycycline. |
164084 | mTORC1 Focused library | Lentiviral CRISPR library targets human mTORC1 signaling pathway |