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TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap.

McShan AC, Devlin CA, Morozov GI, Overall SA, Moschidi D, Akella N, Procko E, Sgourakis NG
Nat Commun. 2021 May 26;12(1):3174. doi: 10.1038/s41467-021-23225-6. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
141308pCEP4-FLAG-TapasinMammalian expression of FLAG-tagged Tapasin
141309pCEP4-FLAG-TAPBPR-tapasinCTMammalian expression of FLAG-tagged TAPBPR with tapasin CT
153471pCEP4-FLAG-TAPBPR-tapasinCT deltaALASMammalian expression of FLAG-tagged TAPBPR with tapasin CT deltaALAS
153472pCEP4-FLAG-TAPBPR-tapasinCT delta24-36Mammalian expression of FLAG-tagged TAPBPR with tapasin CT delta24-36
153473pCEP4-FLAG-TAPBPR-tapasinCT E102AMammalian expression of FLAG-tagged TAPBPR with tapasin CT E102A
153474pCEP4-FLAG-TAPBPR-tapasinCT M122AMammalian expression of FLAG-tagged TAPBPR with tapasin CT M122A
153475pCEP4-FLAG-TAPBPR-tapasinCT G212AMammalian expression of FLAG-tagged TAPBPR with tapasin CT G212A
153476pCEP4-FLAG-TAPBPR-tapasinCT I261AMammalian expression of FLAG-tagged TAPBPR with tapasin CT I261A
153477pCEP4-FLAG-TAPBPR-tapasinCT S333AMammalian expression of FLAG-tagged TAPBPR with tapasin CT S333A
153478pCEP4-FLAG-Tapasin-TAPBPR 22-35Mammalian expression of FLAG-tagged Tapasin with TAPBPR a.a. 22-35
153479pCEP4-FLAG-Tapasin delta2stepMammalian expression of FLAG-tagged Tapasin delta2step
153480pCEP4-FLAG-Tapasin delta3stepMammalian expression of FLAG-tagged Tapasin delta3step
153481pCEP4-FLAG-Tapasin G15EMammalian expression of FLAG-tagged Tapasin G15E
153482pCEP4-FLAG-Tapasin G15LMammalian expression of FLAG-tagged Tapasin G15L
153483pCEP4-FLAG-Tapasin L18EMammalian expression of FLAG-tagged Tapasin L18E
153484pCEP4-FLAG-Tapasin L18GMammalian expression of FLAG-tagged Tapasin L18G
153485pCEP4-FLAG-Tapasin L18KMammalian expression of FLAG-tagged Tapasin L18K
153486pETCON-Aga2p-TAPBPR-mycYeast expression of Aga2p-TAPBPR-myc

Antibodies from Article