pX602-AAV-TBG::NLS-SaCas9-NLS-HA-OLLAS-bGHpA;U6::BsaI-sgRNA Citations (23)
Originally described in: In vivo genome editing using Staphylococcus aureus Cas9.Ran FA, Cong L, Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F Nature. 2015 Apr 1. doi: 10.1038/nature14299. PubMed Journal
Articles Citing pX602-AAV-TBG::NLS-SaCas9-NLS-HA-OLLAS-bGHpA;U6::BsaI-sgRNA
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| Editing Citrus Genome via SaCas9/sgRNA System. Jia H, Xu J, Orbovic V, Zhang Y, Wang N. Front Plant Sci. 2017 Dec 12;8:2135. doi: 10.3389/fpls.2017.02135. eCollection 2017. PubMed |
| Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer. Jeong SH, Kim HB, Kim MC, Lee JM, Lee JH, Kim JH, Kim JW, Park WY, Kim SY, Kim JB, Kim H, Kim JM, Choi HS, Lim DS. J Clin Invest. 2018 Mar 1;128(3):1010-1025. doi: 10.1172/JCI95802. Epub 2018 Feb 5. PubMed |
| Inactivating hepatic follistatin alleviates hyperglycemia. Tao R, Wang C, Stohr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF. Nat Med. 2018 Jul;24(7):1058-1069. doi: 10.1038/s41591-018-0048-0. Epub 2018 Jun 4. PubMed |
| In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia. Pan X, Philippen L, Lahiri SK, Lee C, Park SH, Word TA, Li N, Jarrett KE, Gupta R, Reynolds JO, Lin J, Bao G, Lagor WR, Wehrens XHT. Circ Res. 2018 Sep 28;123(8):953-963. doi: 10.1161/CIRCRESAHA.118.313369. PubMed |
| CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I. Zabaleta N, Barberia M, Martin-Higueras C, Zapata-Linares N, Betancor I, Rodriguez S, Martinez-Turrillas R, Torella L, Vales A, Olague C, Vilas-Zornoza A, Castro-Labrador L, Lara-Astiaso D, Prosper F, Salido E, Gonzalez-Aseguinolaza G, Rodriguez-Madoz JR. Nat Commun. 2018 Dec 21;9(1):5454. doi: 10.1038/s41467-018-07827-1. PubMed |
Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing.
Haldeman JM, Conway AE, Arlotto ME, Slentz DH, Muoio DM, Becker TC, Newgard CB.
Nucleic Acids Res. 2018 Dec 27. pii: 5264291. doi: 10.1093/nar/gky1286.
PubMed
Associated Plasmids |
A Self-Deleting AAV-CRISPR System for In Vivo Genome Editing.
Li A, Lee CM, Hurley AE, Jarrett KE, De Giorgi M, Lu W, Balderrama KS, Doerfler AM, Deshmukh H, Ray A, Bao G, Lagor WR.
Mol Ther Methods Clin Dev. 2018 Dec 6;12:111-122. doi: 10.1016/j.omtm.2018.11.009. eCollection 2019 Mar 15.
PubMed
Associated Plasmids |
| Multiplexed promoterless gene expression with CRISPReader. Zhan H, Zhou Q, Gao Q, Li J, Huang W, Liu Y. Genome Biol. 2019 Jun 3;20(1):113. doi: 10.1186/s13059-019-1712-5. PubMed |
| Hepatocyte Stress Increases Expression of Yes-Associated Protein and Transcriptional Coactivator With PDZ-Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis. Mooring M, Fowl BH, Lum SZC, Liu Y, Yao K, Softic S, Kirchner R, Bernstein A, Singhi AD, Jay DG, Kahn CR, Camargo FD, Yimlamai D. Hepatology. 2020 May;71(5):1813-1830. doi: 10.1002/hep.30928. Epub 2020 Jan 3. PubMed |
| Hemophilia A ameliorated in mice by CRISPR-based in vivo genome editing of human Factor VIII. Chen H, Shi M, Gilam A, Zheng Q, Zhang Y, Afrikanova I, Li J, Gluzman Z, Jiang R, Kong LJ, Chen-Tsai RY. Sci Rep. 2019 Nov 14;9(1):16838. doi: 10.1038/s41598-019-53198-y. PubMed |
Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9.
Agudelo D, Carter S, Velimirovic M, Duringer A, Rivest JF, Levesque S, Loehr J, Mouchiroud M, Cyr D, Waters PJ, Laplante M, Moineau S, Goulet A, Doyon Y.
Genome Res. 2020 Jan;30(1):107-117. doi: 10.1101/gr.255414.119. Epub 2020 Jan 3.
PubMed
Associated Plasmids |
| Efficient in vivo editing of OTC-deficient patient-derived primary human hepatocytes. Ginn SL, Amaya AK, Liao SHY, Zhu E, Cunningham SC, Lee M, Hallwirth CV, Logan GJ, Tay SS, Cesare AJ, Pickett HA, Grompe M, Dilworth K, Lisowski L, Alexander IE. JHEP Rep. 2019 Dec 27;2(1):100065. doi: 10.1016/j.jhepr.2019.100065. eCollection 2020 Feb. PubMed |
| In vivo PCSK9 gene editing using an all-in-one self-cleavage AAV-CRISPR system. Li Q, Su J, Liu Y, Jin X, Zhong X, Mo L, Wang Q, Deng H, Yang Y. Mol Ther Methods Clin Dev. 2021 Feb 9;20:652-659. doi: 10.1016/j.omtm.2021.02.005. eCollection 2021 Mar 12. PubMed |
| Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype. Li H, Wu S, Ma X, Li X, Cheng T, Chen Z, Wu J, Lv L, Li L, Xu L, Wang W, Hu Y, Jiang H, Yin Y, Qiu Z, Hu X. Neurosci Bull. 2021 Sep;37(9):1271-1288. doi: 10.1007/s12264-021-00732-6. Epub 2021 Jun 24. PubMed |
| Acute gene inactivation in the adult mouse liver using the CRISPR-Cas9 technology. Wang X, Xu BL, Chen XW. STAR Protoc. 2021 Jun 17;2(3):100611. doi: 10.1016/j.xpro.2021.100611. eCollection 2021 Sep 17. PubMed |
| In vivo CRISPR-Cas9 inhibition of hepatic LDH as treatment of primary hyperoxaluria. Martinez-Turrillas R, Martin-Mallo A, Rodriguez-Diaz S, Zapata-Linares N, Rodriguez-Marquez P, San Martin-Uriz P, Vilas-Zornoza A, Calleja-Cervantes ME, Salido E, Prosper F, Rodriguez-Madoz JR. Mol Ther Methods Clin Dev. 2022 Mar 16;25:137-146. doi: 10.1016/j.omtm.2022.03.006. eCollection 2022 Jun 9. PubMed |
| An obesogenic feedforward loop involving PPARgamma, acyl-CoA binding protein and GABAA receptor. Anagnostopoulos G, Motino O, Li S, Carbonnier V, Chen H, Sica V, Durand S, Bourgin M, Aprahamian F, Nirmalathasan N, Donne R, Desdouets C, Sola MS, Kotta K, Montegut L, Lambertucci F, Surdez D, Sandrine G, Delattre O, Maiuri MC, Bravo-San Pedro JM, Martins I, Kroemer G. Cell Death Dis. 2022 Apr 18;13(4):356. doi: 10.1038/s41419-022-04834-5. PubMed |
| TadA orthologs enable both cytosine and adenine editing of base editors. Zhang S, Yuan B, Cao J, Song L, Chen J, Qiu J, Qiu Z, Zhao XM, Chen J, Cheng TL. Nat Commun. 2023 Jan 26;14(1):414. doi: 10.1038/s41467-023-36003-3. PubMed |
| TadA reprogramming to generate potent miniature base editors with high precision. Zhang S, Song L, Yuan B, Zhang C, Cao J, Chen J, Qiu J, Tai Y, Chen J, Qiu Z, Zhao XM, Cheng TL. Nat Commun. 2023 Jan 26;14(1):413. doi: 10.1038/s41467-023-36004-2. PubMed |
| Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice. Fang Z, Fan M, Yuan D, Jin L, Wang Y, Ding L, Xu S, Tu J, Zhang E, Wu X, Chen ZB, Huang W. Commun Biol. 2023 Jan 27;6(1):105. doi: 10.1038/s42003-023-04483-0. PubMed |
| Genome Editing of Murine Liver Hepatocytes by AAV Vector-Mediated Expression of Cas9 In Vivo. Kashiwakura Y, Ohmori T. Methods Mol Biol. 2023;2637:195-211. doi: 10.1007/978-1-0716-3016-7_15. PubMed |
| Discovering human cell-compatible gene therapy virus variants via optimized screening in mouse models. Dai M, Yang N, Xu K, Zhang J, Li X, Zhang Y, Li W. Cell Prolif. 2024 Mar;57(3):e13565. doi: 10.1111/cpr.13565. Epub 2023 Oct 20. PubMed |
| Protective role of RIPK1 scaffolding against HDV-induced hepatocyte cell death and the significance of cytokines in mice. Camps G, Maestro S, Torella L, Herrero D, Usai C, Bilbao-Arribas M, Aldaz A, Olague C, Vales A, Suarez-Amaran L, Aldabe R, Gonzalez-Aseguinolaza G. PLoS Pathog. 2024 May 13;20(5):e1011749. doi: 10.1371/journal.ppat.1011749. eCollection 2024 May. PubMed |
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