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MS2-P65-HSF1_GFP Citations (42)

Originally described in: Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.
Konermann S, Brigham MD, Trevino AE, Joung J, Abudayyeh OO, Barcena C, Hsu PD, Habib N, Gootenberg JS, Nishimasu H, Nureki O, Zhang F Nature. 2014 Dec 10. doi: 10.1038/nature14136. PubMed Journal

Articles Citing MS2-P65-HSF1_GFP

Articles
Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease. Dahlman JE, Abudayyeh OO, Joung J, Gootenberg JS, Zhang F, Konermann S. Nat Biotechnol. 2015 Oct 5;33(11):1159-1161. doi: 10.1038/nbt.3390. PubMed
Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9. Kaczmarczyk L, Mende Y, Zevnik B, Jackson WS. PLoS One. 2016 Apr 29;11(4):e0154604. doi: 10.1371/journal.pone.0154604. eCollection 2016. PubMed

Associated Plasmids
Targeted HIV-1 Latency Reversal Using CRISPR/Cas9-Derived Transcriptional Activator Systems. Bialek JK, Dunay GA, Voges M, Schafer C, Spohn M, Stucka R, Hauber J, Lange UC. PLoS One. 2016 Jun 24;11(6):e0158294. doi: 10.1371/journal.pone.0158294. eCollection 2016. PubMed
Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension. Chen F, Li X, Aquadro E, Haigh S, Zhou J, Stepp DW, Weintraub NL, Barman SA, Fulton DJ. Free Radic Biol Med. 2016 Oct;99:167-178. doi: 10.1016/j.freeradbiomed.2016.08.003. Epub 2016 Aug 3. PubMed
Epigenetic Regulation of Interleukin 6 by Histone Acetylation in Macrophages and Its Role in Paraquat-Induced Pulmonary Fibrosis. Hu L, Yu Y, Huang H, Fan H, Hu L, Yin C, Li K, Fulton DJ, Chen F. Front Immunol. 2017 Jan 30;7:696. doi: 10.3389/fimmu.2016.00696. eCollection 2016. PubMed
Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs. Ferry QR, Lyutova R, Fulga TA. Nat Commun. 2017 Mar 3;8:14633. doi: 10.1038/ncomms14633. PubMed
CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation. Nihongaki Y, Furuhata Y, Otabe T, Hasegawa S, Yoshimoto K, Sato M. Nat Methods. 2017 Oct;14(10):963-966. doi: 10.1038/nmeth.4430. Epub 2017 Sep 11. PubMed
Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage. Kulcsar PI, Talas A, Huszar K, Ligeti Z, Toth E, Weinhardt N, Fodor E, Welker E. Genome Biol. 2017 Oct 6;18(1):190. doi: 10.1186/s13059-017-1318-8. PubMed

Associated Plasmids
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation. Liao HK, Hatanaka F, Araoka T, Reddy P, Wu MZ, Sui Y, Yamauchi T, Sakurai M, O'Keefe DD, Nunez-Delicado E, Guillen P, Campistol JM, Wu CJ, Lu LF, Esteban CR, Izpisua Belmonte JC. Cell. 2017 Dec 14;171(7):1495-1507.e15. doi: 10.1016/j.cell.2017.10.025. Epub 2017 Dec 7. PubMed

Associated Plasmids
Activation of the Anti-Aging and Cognition-Enhancing Gene Klotho by CRISPR-dCas9 Transcriptional Effector Complex. Chen CD, Zeldich E, Li Y, Yuste A, Abraham CR. J Mol Neurosci. 2018 Feb;64(2):175-184. doi: 10.1007/s12031-017-1011-0. Epub 2018 Jan 19. PubMed
Genome and epigenome engineering CRISPR toolkit for in vivo modulation of cis-regulatory interactions and gene expression in the chicken embryo. Williams RM, Senanayake U, Artibani M, Taylor G, Wells D, Ahmed AA, Sauka-Spengler T. Development. 2018 Feb 23;145(4). pii: dev.160333. doi: 10.1242/dev.160333. PubMed

Associated Plasmids
Pinpointing recurrent proviral integration sites in new models for latent HIV-1 infection. Lange UC, Bialek JK, Walther T, Hauber J. Virus Res. 2018 Apr 2;249:69-75. doi: 10.1016/j.virusres.2018.03.007. Epub 2018 Mar 14. PubMed
lncRNA PAPAS tethered to the rDNA enhancer recruits hypophosphorylated CHD4/NuRD to repress rRNA synthesis at elevated temperatures. Zhao Z, Senturk N, Song C, Grummt I. Genes Dev. 2018 Jun 1;32(11-12):836-848. doi: 10.1101/gad.311688.118. Epub 2018 Jun 15. PubMed
Biased genome editing using the local accumulation of DSB repair molecules system. Nakade S, Mochida K, Kunii A, Nakamae K, Aida T, Tanaka K, Sakamoto N, Sakuma T, Yamamoto T. Nat Commun. 2018 Aug 16;9(1):3270. doi: 10.1038/s41467-018-05773-6. PubMed
CRISPRa-mediated NEAT1 lncRNA upregulation induces formation of intact paraspeckles. Yamazaki T, Fujikawa C, Kubota A, Takahashi A, Hirose T. Biochem Biophys Res Commun. 2018 Sep 26;504(1):218-224. doi: 10.1016/j.bbrc.2018.08.158. Epub 2018 Sep 1. PubMed
Expanding the repertoire of glucocorticoid receptor target genes by engineering genomic response elements. Thormann V, Glaser LV, Rothkegel MC, Borschiwer M, Bothe M, Fuchs A, Meijsing SH. Life Sci Alliance. 2019 Mar 13;2(2). pii: 2/2/e201800283. doi: 10.26508/lsa.201800283. Print 2019 Apr. PubMed
CRISPRai for simultaneous gene activation and inhibition to promote stem cell chondrogenesis and calvarial bone regeneration. Truong VA, Hsu MN, Kieu Nguyen NT, Lin MW, Shen CC, Lin CY, Hu YC. Nucleic Acids Res. 2019 Jul 26;47(13):e74. doi: 10.1093/nar/gkz267. PubMed

Associated Plasmids
In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway. Cai Y, Cheng T, Yao Y, Li X, Ma Y, Li L, Zhao H, Bao J, Zhang M, Qiu Z, Xue T. Sci Adv. 2019 Apr 17;5(4):eaav3335. doi: 10.1126/sciadv.aav3335. eCollection 2019 Apr. PubMed
Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes. Ferdosi SR, Ewaisha R, Moghadam F, Krishna S, Park JG, Ebrahimkhani MR, Kiani S, Anderson KS. Nat Commun. 2019 Apr 23;10(1):1842. doi: 10.1038/s41467-019-09693-x. PubMed
Three-Component Repurposed Technology for Enhanced Expression: Highly Accumulable Transcriptional Activators via Branched Tag Arrays. Kunii A, Hara Y, Takenaga M, Hattori N, Fukazawa T, Ushijima T, Yamamoto T, Sakuma T. CRISPR J. 2018 Oct;1:337-347. doi: 10.1089/crispr.2018.0009. PubMed
Enhancement of Precise Gene Editing by the Association of Cas9 With Homologous Recombination Factors. Tran NT, Bashir S, Li X, Rossius J, Chu VT, Rajewsky K, Kuhn R. Front Genet. 2019 Apr 30;10:365. doi: 10.3389/fgene.2019.00365. eCollection 2019. PubMed
Expanding C-T base editing toolkit with diversified cytidine deaminases. Cheng TL, Li S, Yuan B, Wang X, Zhou W, Qiu Z. Nat Commun. 2019 Aug 9;10(1):3612. doi: 10.1038/s41467-019-11562-6. PubMed

Associated Plasmids
CRISPR-based Activation of Endogenous Neurotrophic Genes in Adipose Stem Cell Sheets to Stimulate Peripheral Nerve Regeneration. Hsu MN, Liao HT, Truong VA, Huang KL, Yu FJ, Chen HH, Nguyen TKN, Makarevich P, Parfyonova Y, Hu YC. Theranostics. 2019 Aug 14;9(21):6099-6111. doi: 10.7150/thno.36790. eCollection 2019. PubMed
Controlling the Activity of CRISPR Transcriptional Regulators with Inducible sgRNAs. Ferry QRV, Fulga TA. Methods Mol Biol. 2021;2162:153-184. doi: 10.1007/978-1-0716-0687-2_9. PubMed
Identification of human long noncoding RNAs associated with nonalcoholic fatty liver disease and metabolic homeostasis. Ruan X, Li P, Ma Y, Jiang CF, Chen Y, Shi Y, Gupta N, Seifuddin F, Pirooznia M, Ohnishi Y, Yoneda N, Nishiwaki M, Dumbovic G, Rinn JL, Higuchi Y, Kawai K, Suemizu H, Cao H. J Clin Invest. 2021 Jan 4;131(1). pii: 136336. doi: 10.1172/JCI136336. PubMed
Identification and characterization of a new isoform of small GTPase RhoE. Dai Y, Luo W, Yue X, Ma W, Wang J, Chang J. Commun Biol. 2020 Oct 15;3(1):572. doi: 10.1038/s42003-020-01295-4. PubMed
Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids. Velazquez JJ, LeGraw R, Moghadam F, Tan Y, Kilbourne J, Maggiore JC, Hislop J, Liu S, Cats D, Chuva de Sousa Lopes SM, Plaisier C, Cahan P, Kiani S, Ebrahimkhani MR. Cell Syst. 2021 Jan 20;12(1):41-55.e11. doi: 10.1016/j.cels.2020.11.002. Epub 2020 Dec 7. PubMed
Transcriptional behavior of the HIV-1 promoter in context of the BACH2 prominent proviral integration gene. Hamann MV, Ehmele P, Verdikt R, Bialek-Waldmann JK, Virdi S, Gunther T, Van Lint C, Grundhoff A, Hauber J, Lange UC. Virus Res. 2021 Feb;293:198260. doi: 10.1016/j.virusres.2020.198260. Epub 2020 Dec 11. PubMed
Global discovery of lupus genetic risk variant allelic enhancer activity. Lu X, Chen X, Forney C, Donmez O, Miller D, Parameswaran S, Hong T, Huang Y, Pujato M, Cazares T, Miraldi ER, Ray JP, de Boer CG, Harley JB, Weirauch MT, Kottyan LC. Nat Commun. 2021 Mar 12;12(1):1611. doi: 10.1038/s41467-021-21854-5. PubMed
MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo. Zhang X, Lv S, Luo Z, Hu Y, Peng X, Lv J, Zhao S, Feng J, Huang G, Wan QL, Liu J, Huang H, Luan B, Wang D, Zhao X, Lin Y, Zhou Q, Zhang ZN, Rong Z. Nucleic Acids Res. 2021 Mar 22. pii: 6179929. doi: 10.1093/nar/gkab174. PubMed

Associated Plasmids
CD46 splice variant enhances translation of specific mRNAs linked to an aggressive tumor cell phenotype in bladder cancer. Zeng J, Xu H, Huang C, Sun Y, Xiao H, Yu G, Zhou H, Zhang Y, Yao W, Xiao W, Hu J, Wu L, Xing J, Wang T, Chen Z, Ye Z, Chen K. Mol Ther Nucleic Acids. 2021 Feb 24;24:140-153. doi: 10.1016/j.omtn.2021.02.019. eCollection 2021 Jun 4. PubMed
dCas9-based gene editing for cleavage-free genomic knock-in of long sequences. Wang C, Qu Y, Cheng JKW, Hughes NW, Zhang Q, Wang M, Cong L. Nat Cell Biol. 2022 Feb;24(2):268-278. doi: 10.1038/s41556-021-00836-1. Epub 2022 Feb 10. PubMed

Associated Plasmids
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes. Ma H, de Zwaan E, Guo YE, Cejas P, Thiru P, van de Bunt M, Jeppesen JF, Syamala S, Dall'Agnese A, Abraham BJ, Fu D, Garrett-Engele C, Lee TI, Long HW, Griffith LG, Young RA, Jaenisch R. Cell Stem Cell. 2022 Apr 13. pii: S1934-5909(22)00150-3. doi: 10.1016/j.stem.2022.03.015. PubMed

Associated Plasmids
CRISPR-Cas12a System With Synergistic Phage Recombination Proteins for Multiplex Precision Editing in Human Cells. Wang C, Xia Q, Zhang Q, Qu Y, Su S, Cheng JKW, Hughes NW, Cong L. Front Cell Dev Biol. 2022 Jun 14;9:719705. doi: 10.3389/fcell.2021.719705. eCollection 2021. PubMed
Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer-promoter interactions. Wang K, Escobar M, Li J, Mahata B, Goell J, Shah S, Cluck M, Hilton IB. Nucleic Acids Res. 2022 Aug 12;50(14):7842-7855. doi: 10.1093/nar/gkac582. PubMed
A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors. Wang J, Wang A, Tian K, Hua X, Zhang B, Zheng Y, Kong X, Li W, Xu L, Wang J, Li Z, Liu Y, Zhou Y. Cell Discov. 2022 Aug 2;8(1):74. doi: 10.1038/s41421-022-00421-2. PubMed
Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer's Disease. Leung HW, Foo G, VanDongen A. Biomedicines. 2022 Aug 11;10(8):1946. doi: 10.3390/biomedicines10081946. PubMed
Activation of stably silenced genes by recruitment of a synthetic de-methylating module. Chan WF, Coughlan HD, Chen Y, Keenan CR, Smyth GK, Perkins AC, Johanson TM, Allan RS. Nat Commun. 2022 Sep 23;13(1):5582. doi: 10.1038/s41467-022-33181-4. PubMed

Associated Plasmids
A synthetic transcription platform for programmable gene expression in mammalian cells. Chen WCW, Gaidukov L, Lai Y, Wu MR, Cao J, Gutbrod MJ, Choi GCG, Utomo RP, Chen YC, Wroblewska L, Kellis M, Zhang L, Weiss R, Lu TK. Nat Commun. 2022 Oct 18;13(1):6167. doi: 10.1038/s41467-022-33287-9. PubMed
Viscosity-aided electromechanical poration of cells for transfecting molecules. Huang W, Sakuma S, Tottori N, Sugano SS, Yamanishi Y. Lab Chip. 2022 Nov 8;22(22):4276-4291. doi: 10.1039/d2lc00628f. PubMed
Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma. Sgro A, Cursons J, Waryah C, Woodward EA, Foroutan M, Lyu R, Yeoh GCT, Leedman PJ, Blancafort P. Clin Epigenetics. 2023 Apr 29;15(1):73. doi: 10.1186/s13148-023-01482-0. PubMed
CRISPR-Hybrid: A CRISPR-Mediated Intracellular Directed Evolution Platform for RNA Aptamers. Su-Tobon Q, Fan J, Feeney K, Ren H, Autissier P, Wang P, Huang Y, Niu J. bioRxiv [Preprint]. 2023 Aug 30:2023.08.29.555185. doi: 10.1101/2023.08.29.555185. PubMed

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