pMPRA1 Citations (18)
Originally described in: Massively parallel reporter assays in cultured Mammalian cells.Melnikov A, Zhang X, Rogov P, Wang L, Mikkelsen TS J Vis Exp. 2014 Aug 17;(90). doi: 10.3791/51719. PubMed Journal
Articles Citing pMPRA1
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Massively parallel reporter assays in cultured Mammalian cells.
Melnikov A, Zhang X, Rogov P, Wang L, Mikkelsen TS.
J Vis Exp. 2014 Aug 17;(90). doi: 10.3791/51719.
PubMed
Associated Plasmids |
| Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior. Doan RN, Bae BI, Cubelos B, Chang C, Hossain AA, Al-Saad S, Mukaddes NM, Oner O, Al-Saffar M, Balkhy S, Gascon GG, Nieto M, Walsh CA. Cell. 2016 Oct 6;167(2):341-354.e12. doi: 10.1016/j.cell.2016.08.071. Epub 2016 Sep 22. PubMed |
| Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, Melnikov A, Zhang X, Wang L, Rogov P, Mikkelsen TS, Kellis M. Nat Biotechnol. 2016 Nov;34(11):1180-1190. doi: 10.1038/nbt.3678. Epub 2016 Oct 3. PubMed |
| Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. Pashos EE, Park Y, Wang X, Raghavan A, Yang W, Abbey D, Peters DT, Arbelaez J, Hernandez M, Kuperwasser N, Li W, Lian Z, Liu Y, Lv W, Lytle-Gabbin SL, Marchadier DH, Rogov P, Shi J, Slovik KJ, Stylianou IM, Wang L, Yan R, Zhang X, Kathiresan S, Duncan SA, Mikkelsen TS, Morrisey EE, Rader DJ, Brown CD, Musunuru K. Cell Stem Cell. 2017 Apr 6;20(4):558-570.e10. doi: 10.1016/j.stem.2017.03.017. PubMed |
| A screen of 1,049 schizophrenia and 30 Alzheimer's-associated variants for regulatory potential. Myint L, Wang R, Boukas L, Hansen KD, Goff LA, Avramopoulos D. Am J Med Genet B Neuropsychiatr Genet. 2020 Jan;183(1):61-73. doi: 10.1002/ajmg.b.32761. Epub 2019 Sep 10. PubMed |
| Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors. Mazrooei P, Kron KJ, Zhu Y, Zhou S, Grillo G, Mehdi T, Ahmed M, Severson TM, Guilhamon P, Armstrong NS, Huang V, Yamaguchi TN, Fraser M, van der Kwast T, Boutros PC, He HH, Bergman AM, Bristow RG, Zwart W, Lupien M. Cancer Cell. 2019 Dec 9;36(6):674-689.e6. doi: 10.1016/j.ccell.2019.10.005. Epub 2019 Nov 14. PubMed |
| Genomic analyses implicate noncoding de novo variants in congenital heart disease. Richter F, Morton SU, Kim SW, Kitaygorodsky A, Wasson LK, Chen KM, Zhou J, Qi H, Patel N, DePalma SR, Parfenov M, Homsy J, Gorham JM, Manheimer KB, Velinder M, Farrell A, Marth G, Schadt EE, Kaltman JR, Newburger JW, Giardini A, Goldmuntz E, Brueckner M, Kim R, Porter GA Jr, Bernstein D, Chung WK, Srivastava D, Tristani-Firouzi M, Troyanskaya OG, Dickel DE, Shen Y, Seidman JG, Seidman CE, Gelb BD. Nat Genet. 2020 Aug;52(8):769-777. doi: 10.1038/s41588-020-0652-z. Epub 2020 Jun 29. PubMed |
| Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions. Girskis KM, Stergachis AB, DeGennaro EM, Doan RN, Qian X, Johnson MB, Wang PP, Sejourne GM, Nagy MA, Pollina EA, Sousa AMM, Shin T, Kenny CJ, Scotellaro JL, Debo BM, Gonzalez DM, Rento LM, Yeh RC, Song JHT, Beaudin M, Fan J, Kharchenko PV, Sestan N, Greenberg ME, Walsh CA. Neuron. 2021 Oct 20;109(20):3239-3251.e7. doi: 10.1016/j.neuron.2021.08.005. Epub 2021 Sep 2. PubMed |
| A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci. Joslin AC, Sobreira DR, Hansen GT, Sakabe NJ, Aneas I, Montefiori LE, Farris KM, Gu J, Lehman DM, Ober C, He X, Nobrega MA. Nat Commun. 2021 Sep 6;12(1):5253. doi: 10.1038/s41467-021-25614-3. PubMed |
| Identifying the lungs as a susceptible site for allele-specific regulatory changes associated with type 1 diabetes risk. Ho D, Nyaga DM, Schierding W, Saffery R, Perry JK, Taylor JA, Vickers MH, Kempa-Liehr AW, O'Sullivan JM. Commun Biol. 2021 Sep 14;4(1):1072. doi: 10.1038/s42003-021-02594-0. PubMed |
| Multimodal profiling of the transcriptional regulatory landscape of the developing mouse cortex identifies Neurog2 as a key epigenome remodeler. Noack F, Vangelisti S, Raffl G, Carido M, Diwakar J, Chong F, Bonev B. Nat Neurosci. 2022 Feb;25(2):154-167. doi: 10.1038/s41593-021-01002-4. Epub 2022 Feb 7. PubMed |
| Denisovan introgression has shaped the immune system of present-day Papuans. Vespasiani DM, Jacobs GS, Cook LE, Brucato N, Leavesley M, Kinipi C, Ricaut FX, Cox MP, Gallego Romero I. PLoS Genet. 2022 Dec 8;18(12):e1010470. doi: 10.1371/journal.pgen.1010470. eCollection 2022 Dec. PubMed |
| Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment. Bhattarai KR, Mobley RJ, Barnett KR, Ferguson DC, Hansen BS, Diedrich JD, Bergeron BP, Yang W, Crews KR, Manring CS, Jabbour E, Paietta E, Litzow MR, Kornblau SM, Stock W, Inaba H, Jeha S, Pui CH, Cheng C, Pruett-Miller SM, Relling MV, Yang JJ, Evans WE, Savic D. medRxiv [Preprint]. 2023 Feb 11:2023.02.10.23285762. doi: 10.1101/2023.02.10.23285762. PubMed |
| Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals. Kliesmete Z, Wange LE, Vieth B, Esgleas M, Radmer J, Hulsmann M, Geuder J, Richter D, Ohnuki M, Gotz M, Hellmann I, Enard W. Elife. 2023 Mar 22;12:e83593. doi: 10.7554/eLife.83593. PubMed |
| Rare variation in noncoding regions with evolutionary signatures contributes to autism spectrum disorder risk. Shin T, Song JHT, Kosicki M, Kenny C, Beck SG, Kelley L, Qian X, Bonacina J, Papandile F, Antony I, Gonzalez D, Scotellaro J, Bushinsky EM, Andersen RE, Maury E, Pennacchio LA, Doan RN, Walsh CA. medRxiv [Preprint]. 2023 Sep 22:2023.09.19.23295780. doi: 10.1101/2023.09.19.23295780. PubMed |
| Genome-wide census of ATF4 binding sites and functional profiling of trait-associated genetic variants overlapping ATF4 binding motifs. Ord T, Ord D, Adler P, Ord T. PLoS Genet. 2023 Oct 31;19(10):e1011014. doi: 10.1371/journal.pgen.1011014. eCollection 2023 Oct. PubMed |
| Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids. Noack F, Vangelisti S, Ditzer N, Chong F, Albert M, Bonev B. Nat Cell Biol. 2023 Dec;25(12):1873-1883. doi: 10.1038/s41556-023-01296-5. Epub 2023 Nov 23. PubMed |
| The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex. Cubillos P, Ditzer N, Kolodziejczyk A, Schwenk G, Hoffmann J, Schutze TM, Derihaci RP, Birdir C, Kollner JE, Petzold A, Sarov M, Martin U, Long KR, Wimberger P, Albert M. EMBO J. 2024 Apr;43(8):1388-1419. doi: 10.1038/s44318-024-00068-7. Epub 2024 Mar 21. PubMed |
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