FUdeltaGW-rtTA Citations (50)
Originally described in: A high-efficiency system for the generation and study of human induced pluripotent stem cells.Maherali N, Ahfeldt T, Rigamonti A, Utikal J, Cowan C, Hochedlinger K Cell Stem Cell. 2008 Sep 11. 3(3):340-5. PubMed Journal
Articles Citing FUdeltaGW-rtTA
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| The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cordenonsi M, Zanconato F, Azzolin L, Forcato M, Rosato A, Frasson C, Inui M, Montagner M, Parenti AR, Poletti A, Daidone MG, Dupont S, Basso G, Bicciato S, Piccolo S. Cell. 2011 Nov 11;147(4):759-72. doi: 10.1016/j.cell.2011.09.048. PubMed |
Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector.
Addis RC, Hsu FC, Wright RL, Dichter MA, Coulter DA, Gearhart JD.
PLoS One. 2011;6(12):e28719. doi: 10.1371/journal.pone.0028719. Epub 2011 Dec 9.
PubMed
Associated Plasmids |
Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success.
Addis RC, Ifkovits JL, Pinto F, Kellam LD, Esteso P, Rentschler S, Christoforou N, Epstein JA, Gearhart JD.
J Mol Cell Cardiol. 2013 Apr 13;60C:97-106. doi: 10.1016/j.yjmcc.2013.04.004.
PubMed
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| Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. Christoforou N, Chellappan M, Adler AF, Kirkton RD, Wu T, Addis RC, Bursac N, Leong KW. PLoS One. 2013 May 21;8(5):e63577. doi: 10.1371/journal.pone.0063577. Print 2013. PubMed |
| Inhibition of TGFbeta signaling increases direct conversion of fibroblasts to induced cardiomyocytes. Ifkovits JL, Addis RC, Epstein JA, Gearhart JD. PLoS One. 2014 Feb 26;9(2):e89678. doi: 10.1371/journal.pone.0089678. eCollection 2014. PubMed |
| Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes. Rudraiah S, Rohrer PR, Gurevich I, Goedken MJ, Rasmussen T, Hines RN, Manautou JE. Toxicol Sci. 2014 Sep;141(1):263-77. doi: 10.1093/toxsci/kfu124. Epub 2014 Jun 27. PubMed |
| Aerobic glycolysis tunes YAP/TAZ transcriptional activity. Enzo E, Santinon G, Pocaterra A, Aragona M, Bresolin S, Forcato M, Grifoni D, Pession A, Zanconato F, Guzzo G, Bicciato S, Dupont S. EMBO J. 2015 May 12;34(10):1349-70. doi: 10.15252/embj.201490379. Epub 2015 Mar 21. PubMed |
| Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells. Birket MJ, Ribeiro MC, Verkerk AO, Ward D, Leitoguinho AR, den Hartogh SC, Orlova VV, Devalla HD, Schwach V, Bellin M, Passier R, Mummery CL. Nat Biotechnol. 2015 Sep;33(9):970-9. doi: 10.1038/nbt.3271. Epub 2015 Jul 20. PubMed |
Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells.
Ho SM, Hartley BJ, Tcw J, Beaumont M, Stafford K, Slesinger PA, Brennand KJ.
Methods. 2015 Nov 25. pii: S1046-2023(15)30159-6. doi: 10.1016/j.ymeth.2015.11.019.
PubMed
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| Induced Pluripotent Stem Cells of Microtus levis x Microtus arvalis Vole Hybrids: Conditions Necessary for Their Generation and Self-Renewal. Grigor'eva EV, Shevchenko AI, Medvedev SP, Mazurok NA, Zhelezova AI, Zakian SM. Acta Naturae. 2015 Oct-Dec;7(4):56-69. PubMed |
| Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. Zheng X, Boyer L, Jin M, Mertens J, Kim Y, Ma L, Ma L, Hamm M, Gage FH, Hunter T. Elife. 2016 Jun 10;5. pii: e13374. doi: 10.7554/eLife.13374. PubMed |
| Protocol for the Direct Conversion of Murine Embryonic Fibroblasts into Trophoblast Stem Cells. Kubaczka C, Schorle H. J Vis Exp. 2016 Jul 25;(113). doi: 10.3791/54277. PubMed |
| Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models. Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Muller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ. Mol Psychiatry. 2016 Oct 18. doi: 10.1038/mp.2016.163. PubMed |
| Systematic in vitro and in vivo characterization of Leukemia-inhibiting factor- and Fibroblast growth factor-derived porcine induced pluripotent stem cells. Secher JO, Ceylan A, Mazzoni G, Mashayekhi K, Li T, Muenthaisong S, Nielsen TT, Li D, Li S, Petkov S, Cirera S, Luo Y, Thombs L, Kadarmideen HN, Dinnyes A, Bolund L, Roelen BA, Schmidt M, Callesen H, Hyttel P, Freude KK. Mol Reprod Dev. 2017 Jan 3. doi: 10.1002/mrd.22771. PubMed |
| Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage. Christoforou N, Chakraborty S, Kirkton RD, Adler AF, Addis RC, Leong KW. Sci Rep. 2017 Jan 10;7:40285. doi: 10.1038/srep40285. PubMed |
| YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate. Totaro A, Castellan M, Battilana G, Zanconato F, Azzolin L, Giulitti S, Cordenonsi M, Piccolo S. Nat Commun. 2017 May 17;8:15206. doi: 10.1038/ncomms15206. PubMed |
| Trap(Seq): An RNA Sequencing-Based Pipeline for the Identification of Gene-Trap Insertions in Mammalian Cells. Mayor-Ruiz C, Dominguez O, Fernandez-Capetillo O. J Mol Biol. 2017 Sep 1;429(18):2780-2789. doi: 10.1016/j.jmb.2017.07.020. Epub 2017 Aug 4. PubMed |
| Microenvironment dependent gene expression signatures in reprogrammed human colon normal and cancer cell lines. Strainiene E, Binkis M, Urnikyte S, Stankevicius V, Sasnauskiene A, Kundrotas G, Kazlauskas A, Suziedelis K. BMC Cancer. 2018 Feb 27;18(1):222. doi: 10.1186/s12885-018-4145-8. PubMed |
| Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. Ordureau A, Paulo JA, Zhang W, Ahfeldt T, Zhang J, Cohn EF, Hou Z, Heo JM, Rubin LL, Sidhu SS, Gygi SP, Harper JW. Mol Cell. 2018 Apr 19;70(2):211-227.e8. doi: 10.1016/j.molcel.2018.03.012. Epub 2018 Apr 12. PubMed |
| FRA1 mediates the activation of keratinocytes: Implications for the development of psoriatic plaques. Zolotarenko A, Chekalin E, Piruzian E, Bruskin S. Biochim Biophys Acta Mol Basis Dis. 2018 Dec;1864(12):3726-3734. doi: 10.1016/j.bbadis.2018.09.016. Epub 2018 Sep 14. PubMed |
| The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S. Nature. 2018 Nov;563(7730):265-269. doi: 10.1038/s41586-018-0658-1. Epub 2018 Oct 31. PubMed |
| Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression. Srikanth P, Lagomarsino VN, Pearse RV 2nd, Liao M, Ghosh S, Nehme R, Seyfried N, Eggan K, Young-Pearse TL. Transl Psychiatry. 2018 Nov 8;8(1):245. doi: 10.1038/s41398-018-0281-9. PubMed |
| Lipidomic Analysis of alpha-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4. PubMed |
| A New MicroRNA Cluster Involved in the Reprogramming to a Pluripotent State. Sherstyuk VV, Davletshina GI, Vyatkin YV, Shtokalo DN, Vlasov VV, Zakian SM. Acta Naturae. 2019 Apr-Jun;11(2):92-97. doi: 10.32607/20758251-2019-11-2-92-97. PubMed |
| mTOR and autophagy pathways are dysregulated in murine and human models of Schaaf-Yang syndrome. Crutcher E, Pal R, Naini F, Zhang P, Laugsch M, Kim J, Bajic A, Schaaf CP. Sci Rep. 2019 Nov 4;9(1):15935. doi: 10.1038/s41598-019-52287-2. PubMed |
| ASCL1- and DLX2-induced GABAergic neurons from hiPSC-derived NPCs. Barretto N, Zhang H, Powell SK, Fernando MB, Zhang S, Flaherty EK, Ho SM, Slesinger PA, Duan J, Brennand KJ. J Neurosci Methods. 2020 Feb 14;334:108548. doi: 10.1016/j.jneumeth.2019.108548. PubMed |
| Induction of Osteoblasts by Direct Reprogramming of Mouse Fibroblasts. Zhu H, Wu JY. Methods Mol Biol. 2020;2155:201-212. doi: 10.1007/978-1-0716-0655-1_17. PubMed |
Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models.
Gregory JA, Hoelzli E, Abdelaal R, Braine C, Cuevas M, Halpern M, Barretto N, Schrode N, Akbalik G, Kang K, Cheng E, Bowles K, Lotz S, Goderie S, Karch CM, Temple S, Goate A, Brennand KJ, Phatnani H.
Cells. 2020 Jun 5;9(6). pii: cells9061406. doi: 10.3390/cells9061406.
PubMed
Associated Plasmids |
| Nanosecond pulsed electric fields enhance mesenchymal stem cells differentiation via DNMT1-regulated OCT4/NANOG gene expression. Li K, Ning T, Wang H, Jiang Y, Zhang J, Ge Z. Stem Cell Res Ther. 2020 Jul 22;11(1):308. doi: 10.1186/s13287-020-01821-5. PubMed |
| Dorsoventral polarity directs cell responses to migration track geometries. Wisniewski EO, Mistriotis P, Bera K, Law RA, Zhang J, Nikolic M, Weiger M, Parlani M, Tuntithavornwat S, Afthinos A, Zhao R, Wirtz D, Kalab P, Scarcelli G, Friedl P, Konstantopoulos K. Sci Adv. 2020 Jul 31;6(31):eaba6505. doi: 10.1126/sciadv.aba6505. eCollection 2020 Jul. PubMed |
| In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy. Fujimura A, Yasui S, Igawa K, Ueda A, Watanabe K, Hanafusa T, Ichikawa Y, Yoshihashi S, Tsuchida K, Kamiya A, Furuya S. Cells. 2020 Sep 23;9(10). pii: cells9102149. doi: 10.3390/cells9102149. PubMed |
| Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and Microglia. Ryan SK, Jordan-Sciutto KL, Anderson SA. STAR Protoc. 2020 Dec 1;1(3):100190. doi: 10.1016/j.xpro.2020.100190. eCollection 2020 Dec 18. PubMed |
| Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. Uneda A, Kurozumi K, Fujimura A, Fujii K, Ishida J, Shimazu Y, Otani Y, Tomita Y, Hattori Y, Matsumoto Y, Tsuboi N, Makino K, Hirano S, Kamiya A, Date I. Acta Neuropathol Commun. 2021 Feb 22;9(1):29. doi: 10.1186/s40478-021-01124-7. PubMed |
| Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in Glioblastoma. Castellan M, Guarnieri A, Fujimura A, Zanconato F, Battilana G, Panciera T, Sladitschek HL, Contessotto P, Citron A, Grilli A, Romano O, Bicciato S, Fassan M, Porcu E, Rosato A, Cordenonsi M, Piccolo S. Nat Cancer. 2021 Feb;2(2):174-188. doi: 10.1038/s43018-020-00150-z. Epub 2020 Dec 7. PubMed |
| Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors. Lagomarsino VN, Pearse RV 2nd, Liu L, Hsieh YC, Fernandez MA, Vinton EA, Paull D, Felsky D, Tasaki S, Gaiteri C, Vardarajan B, Lee H, Muratore CR, Benoit CR, Chou V, Fancher SB, He A, Merchant JP, Duong DM, Martinez H, Zhou M, Bah F, Vicent MA, Stricker JMS, Xu J, Dammer EB, Levey AI, Chibnik LB, Menon V, Seyfried NT, De Jager PL, Noggle S, Selkoe DJ, Bennett DA, Young-Pearse TL. Neuron. 2021 Nov 3;109(21):3402-3420.e9. doi: 10.1016/j.neuron.2021.08.003. Epub 2021 Sep 1. PubMed |
| VLDLR and ApoER2 are receptors for multiple alphaviruses. Clark LE, Clark SA, Lin C, Liu J, Coscia A, Nabel KG, Yang P, Neel DV, Lee H, Brusic V, Stryapunina I, Plante KS, Ahmed AA, Catteruccia F, Young-Pearse TL, Chiu IM, Llopis PM, Weaver SC, Abraham J. Nature. 2022 Feb;602(7897):475-480. doi: 10.1038/s41586-021-04326-0. Epub 2021 Dec 20. PubMed |
| Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE varepsilon2 for Alzheimer's disease. Jun GR, You Y, Zhu C, Meng G, Chung J, Panitch R, Hu J, Xia W, Bennett DA, Foroud TM, Wang LS, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Au R, Lunetta KL, Ikezu T, Stein TD, Farrer LA. Alzheimers Dement. 2022 Nov;18(11):2042-2054. doi: 10.1002/alz.12607. Epub 2022 Feb 9. PubMed |
| APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons. Wu CI, Vinton EA, Pearse RV 2nd, Heo K, Aylward AJ, Hsieh YC, Bi Y, Adeleye S, Fancher S, Duong DM, Seyfried NT, Schwarz TL, Young-Pearse TL. Mol Psychiatry. 2022 Apr;27(4):1970-1989. doi: 10.1038/s41380-022-01454-5. Epub 2022 Feb 23. PubMed |
| The mitochondrial RNA granule modulates manganese-dependent cell toxicity. Werner E, Gokhale A, Ackert M, Xu C, Wen Z, Roberts AM, Roberts BR, Vrailas-Mortimer A, Crocker A, Faundez V. Mol Biol Cell. 2022 Oct 1;33(12):ar108. doi: 10.1091/mbc.E22-03-0096. Epub 2022 Aug 3. PubMed |
| Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements. Ibarra IL, Ratnu VS, Gordillo L, Hwang IY, Mariani L, Weinand K, Hammaren HM, Heck J, Bulyk ML, Savitski MM, Zaugg JB, Noh KM. Mol Syst Biol. 2022 Aug;18(8):e10473. doi: 10.15252/msb.202110473. PubMed |
| Generation of a recombinant version of a biologically active cell-permeant human HAND2 transcription factor from E. coli. Haridhasapavalan KK, Sundaravadivelu PK, Joshi N, Das NJ, Mohapatra A, Voorkara U, Kaveeshwar V, Thummer RP. Sci Rep. 2022 Sep 27;12(1):16129. doi: 10.1038/s41598-022-19745-w. PubMed |
| Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer's disease risk gene SORL1. Lee H, Aylward AJ, Pearse RV, Hsieh YC, Augur ZM, Benoit CR, Chou V, Knupp A, Pan C, Goberdhan S, Duong DM, Seyfried NT, Bennett DA, Klein HU, De Jager PL, Menon V, Young JE, Young-Pearse TL. bioRxiv. 2023 Feb 25:2023.02.25.530017. doi: 10.1101/2023.02.25.530017. Preprint. PubMed |
| Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction. Breitmeyer R, Vogel S, Heider J, Hartmann SM, Wust R, Keller AL, Binner A, Fitzgerald JC, Fallgatter AJ, Volkmer H. Commun Biol. 2023 Apr 29;6(1):472. doi: 10.1038/s42003-023-04852-9. PubMed |
| Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer's disease. Merchant JP, Zhu K, Henrion MYR, Zaidi SSA, Lau B, Moein S, Alamprese ML, Pearse RV 2nd, Bennett DA, Ertekin-Taner N, Young-Pearse TL, Chang R. Commun Biol. 2023 May 15;6(1):503. doi: 10.1038/s42003-023-04791-5. PubMed |
Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway.
Guo Y, Shen M, Dong Q, Mendez-Albelo NM, Huang SX, Sirois CL, Le J, Li M, Jarzembowski ED, Schoeller KA, Stockton ME, Horner VL, Sousa AMM, Gao Y, Levine JE, Wang D, Chang Q, Zhao X.
Nat Commun. 2023 Jun 26;14(1):3801. doi: 10.1038/s41467-023-39337-0.
PubMed
Associated Plasmids |
| Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing. Nguyen LD, Wei Z, Silva MC, Barberan-Soler S, Zhang J, Rabinovsky R, Muratore CR, Stricker JMS, Hortman C, Young-Pearse TL, Haggarty SJ, Krichevsky AM. Nat Commun. 2023 Nov 21;14(1):7575. doi: 10.1038/s41467-023-43293-0. PubMed |
| INPP5D regulates inflammasome activation in human microglia. Chou V, Pearse RV 2nd, Aylward AJ, Ashour N, Taga M, Terzioglu G, Fujita M, Fancher SB, Sigalov A, Benoit CR, Lee H, Lam M, Seyfried NT, Bennett DA, De Jager PL, Menon V, Young-Pearse TL. Nat Commun. 2023 Nov 29;14(1):7552. doi: 10.1038/s41467-023-42819-w. PubMed |
| Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons. Heider J, Stahl A, Sperlich D, Hartmann SM, Vogel S, Breitmeyer R, Templin M, Volkmer H. BMC Neurosci. 2024 Mar 4;25(1):12. doi: 10.1186/s12868-024-00858-z. PubMed |
| Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons. Hees JT, Wanderoy S, Lindner J, Helms M, Murali Mahadevan H, Harbauer AB. Nat Metab. 2024 Mar;6(3):514-530. doi: 10.1038/s42255-024-01007-w. Epub 2024 Mar 19. PubMed |
| Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders. Jiang J, Wilkinson B, Flores I, Hartel N, Mihaylov SR, Clementel VA, Flynn HR, Alkuraya FS, Ultanir S, Graham NA, Coba MP. Front Mol Neurosci. 2024 Apr 4;17:1359154. doi: 10.3389/fnmol.2024.1359154. eCollection 2024. PubMed |
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