Chemogenetics Guide
Type
Guide
...small molecule ligand. The ideal chemogenetic tools are unresponsive to native ligands and are engineered...transmembrane proteins that bind a specific ligand. Ligand binding then activates G-proteins to modulate...unresponsive to endogenous ligands, could be activated by synthetic ligands. Specifically, R eceptors ...insensitivity to endogenous ligands, have low constitutive activity, and their activating ligands have few, if any...their ligands, and signaling properties. Please see the text or table 1 for details. DREADD Ligands Muscarinic-receptor...Early Chemogenetic Receptors/RASSLs DREADDs DREADD ligands PSAMs Planning your experiment References Introduction...neurotransmission. This, and the fact that GPCR ligands can have high potency, which is potentially important...