...dCas9 alone for mammalian cell lines. Activate (CRISPRa) Increase expression of an endogenous gene(s) without...

...CRISPR interference, or CRISPRi) or activation (CRISPRa) of downstream target genes can be achieved by ...bacterial genomic region used in pathogen defense CRISPRa CRISPR Activation; using a dCas9 or dCas9-activator...protein-interacting RNA aptamers, such as in the CRISPRainbow kit . Using multiple copies of the aptamer improves... loci with dCas9 and engineered sgRNAs using CRISPRainbow. Nature Biotechnology . 34 (5), 528–530. PMID...