CRISPR History and Development for Genome Engineering
Type
Collection
... cell culture. Five years later, PubMed lists more than 6,300 CRISPR-related publications, many of which...specific, programmable platform well-suited for various biological and translational technologies. Biotechnology... a target gene. On the other hand, if a repair template with homology arms was supplied, the break could...could be repaired according to this template, allowing for precise gene editing. These edits can include...convert adenosine to inosine on RNA. Inosine is translated as guanosine, so the overall effect is an A->...to transcriptional activators or repressors can modulate transcription in a reversible manner. Epigenetics...Epigenetics : dCas9 fused to epigenetic modifiers can modulate transcriptions and create heritable epigenetic...