Hot Plasmids September 2018 - Optogenetics, RNA Localization, Fluorescent Protein, and Base-editing Tools
Type
Blog Post
Published
Sept. 18, 2018, 1:33 p.m.
...modulate cellular dynamics with light by modifying EB1. EB1 normally sits on microtubules to attract other...involved in their growth and extension. Now, they split EB1 into two halves (Fig. 1): one containing the microtubule...LOVTRAP domains. When both halves of the modified EB1 protein are overexpressed in cells, microtubule growth...to conformational changes, and as a consequence, EB1 protein function is inactivated by the separation... cancer cell line equipped with photodissociable EB1 could be stopped in areas with blue light - a finding...