We narrowed to 520 results for: arl
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TypeBlog PostPublishedMarch 9, 2017, 3:40 p.m....better, no grant writing Job changes can happen regularly (every 4-6 years is common), but this can also...diverse options and how to take advantage of them early is one way to smooth your path to a fulfilling career...
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What the HEK?
TypeBlog PostPublishedApril 18, 2023, 1:15 p.m....two areas of research where HEK cells may be particularly useful due to their intrinsic properties. ...by mycoplasma and bacteria, but HEKs are also particularly vulnerable to viral infection. Yes, your cells... -
Donations from Addgene to Yield Answers for Rare Disease Researchers
TypeBlog PostPublishedSept. 15, 2015, 2:30 p.m....by mutations in the OCRL1 gene that leads to the early death of young patients as their kidneys fail. The...interested in XP out of a desire to understand the early events in the transformation of healthy cells into... -
Celebrate National Book Month with Addgene
TypeBlog PostPublishedOct. 3, 2019, 12:47 p.m....insects, mammals, and plants, among others. I particularly enjoyed the emphasis that microbes are neither...last 8 years. Since then, we’ve read books across nearly every genre you can imagine: gothic, mystery, sci-fi... -
Fluorescent Protein Travel Awards - Protein Variants, a Serotonin Sensor, and an Artificial Leaf Replica System
TypeBlog PostPublishedJune 4, 2019, 1:02 p.m.... 2017. These travel awards are intended to help early career scientists attend a conference of their choice...evidence suggests that it is incredibly important for nearly every aspect of life.” Unger began with the a bacterial... -
Creating accessible biology activities in schools with BioBits
TypeBlog PostPublishedAug. 2, 2018, 12:56 p.m....thinking: I wish I had this kind of experience earlier! After all, students build circuits in physics... about operating the rest of the car as well. Similarly, cell free expression systems contain all the ... -
Plasmids 101: Gram Negative and Positive Bacteria
TypeBlog PostPublishedAug. 2, 2022, 1:15 p.m....decolorized as gram negative. A German scientist, Carl Weigert, later expanded on Gram’s discovery, adding...resources. Bruckner, M. Gram Staining. https://serc.carleton.edu/microbelife/research_methods/microscopy/gramstain.html... -
Using CRISPR/Cas9 to Edit Disease Out of the Genome
TypeBlog PostPublishedJune 23, 2022, 1:15 p.m....They are targeting the genes responsible for both early onset and late onset AD. In this study, the group...autosomal-dominant mutations that have been connected to the early onset of Alzheimer’s disease, as well as those that... -
Crowdfight, a Platform to Boost Scientific Collaboration During COVID-19 and Beyond
TypeBlog PostPublishedJune 1, 2021, 1:15 p.m.... neutralize the SARS-CoV-2 virus. But while the early results were promising, the researchers did not ... the preprint repository BioRxiv. This example clearly illustrates the power of collaboration, which despite... -
Viral Vectors 101: Inverted Terminal Repeats
TypeBlog PostPublishedOct. 19, 2023, 1:15 p.m....because they demonstrate high promoter activity (Earley et al. 2020), but non-AAV2 ITRs can be used to ...Addgene's AVV guide AAV Viral Preps References Earley, L. F., Conatser, L. M., Lue, V. M., Dobbins, A... -
The MTA at Addgene
TypeBlog PostPublishedJuly 23, 2024, 2:17 p.m....MTAs by the Provider and Recipient (in Addgene parlance, the depositor and requestor) organizations. Over...depends on things being organized, tracked, and clearly communicated. And that’s where MTAs, and similar... -
Addgene Welcomes John Doench to the Advisory Board
TypeBlog PostPublishedAug. 13, 2015, 2:30 p.m....specificity in the miRNA regulatory process. This early research is still relevant to his work at the Broad...screens to learn more about cancer biology in Ed Harlow’s group at Harvard Medical School and then applied... -
Expanding the Targeting Scope and Editing Efficiency of Adenine Base Editors
TypeBlog PostPublishedMarch 17, 2020, 1:32 p.m....Therapies: CRISPR, Stem Cells, and Beyond meeting earlier this month. Another issue that arises for base...cannot be expressed until the base editor corrects early stop codons within T7 RNAP. A phage encoding the... -
Behind the scenes: Addgene’s new search engine and more
TypeBlog PostPublishedDec. 12, 2019, 2:22 p.m....results. The footer and improved menus we launched earlier in the year, as well as our redesigned homepage...categorization of our information in order to more granularly customize the search engine, and a scoping mechanism... -
Hot Plasmids - June 2019 - Optogenetics, Acoustic Reporter Genes, microRNAs, and the CRISPR-Cas9 system CHIME
TypeBlog PostPublishedJune 6, 2019, 12:41 p.m....miRNA reporter podcast segment Discovered in the early 1990’s, microRNAs (miRNAs) are recognized as important...analysis of immune cells has been a gap in the field. Arlene Sharpe’s group at the Harvard Medical School developed... -
Plasmids 101: Inducible Promoters
TypeBlog PostPublishedJan. 18, 2018, 2:34 p.m....between cell types or organisms, promoters are similarly variable. Bacterial promoters only work in prokaryotic...related species from which they were derived. Similarly, the various eukaryotic cell types (mammalian,... -
Antibodies 101: Isotypes
TypeBlog PostPublishedOct. 19, 2021, 1:15 p.m.... in Health and Disease. 5th edition. New York: Garland Science; 2001. Structural variation in immunoglobulin... in Health and Disease. 5th edition. New York: Garland Science; 2001. The distribution and functions of... -
Quick Guide to Working with Drosophila Part 3: Genome Engineering in Flies
TypeBlog PostPublishedJuly 28, 2017, 1:30 p.m....research (3). The sky is the limit. As mentioned earlier, even genes not found in Drosophila can be studied...immunology PhD at Harvard University. He has had nearly a decade of experience working with Drosophila ... -
How to Keep a Lab Notebook for Bioinformatic Analyses
TypeBlog PostPublishedJune 2, 2016, 2:30 p.m....inspired you to perform this analysis. Having a clearly stated, specific goal for each analysis will help...student at University of Pennsylvania. She is particularly interested in science communication and epigenetics... -
Advice for Starting a Biotech Company from a Grad Student turned Entrepreneur
TypeBlog PostPublishedJuly 10, 2014, 7:17 p.m....best, wins. He explained that entrepreneurs must clearly communicate their idea at various levels of complexity...works. “We use functional spectrometers from the early 1990s that were free and free to repair.” If the...