Lighting Up Cell Signaling with Photoswitchable Kinases
Type
Blog Post
Published
July 25, 2017, 1:20 p.m.
... C. elegans, but activation of Raf-MEK-ERK signaling in the hypodermis and gut cells of C. elegans causes... a signaling pathway in the context of a whole organism, but also allows for precise activation of a kinases...utility of photoswitchable kinases in vivo with C. elegans.
Researchers commonly use rectal bacterial infection...Zhou et al also used a photoswitchable CDK5 in C. elegans. See figures 4B and C in Zhou et al for details..., but they need to be expressed in a tissue or organism that blue and violet light can penetrate.
How ...