...For example, we saw that another type of DREADD, hM3Dq, is successfully expressed at the plasma membrane...

... expressing an activating chemogentic receptor (hM3Dq) into a subset of neurons within the LC of mice....

...human muscarinic receptors: hM1Dq, hM3Dq, and hM5Dq, however, hM3Dq is the most widely employed. Gi-DREADDs...SALB). Scientists have shown that both KORD and hM3Dq can be used in the same organism to allow bidirectional...translocation Arrestin signalling Nakajima & Wess, 2012 hM3Dq hM1Dq hM5Dq Human M3 muscarinic G αq CNO* Increase...genetically engineered animal models expressing hM3Dq, hM4Di, and rM3D DREADDs and LMOs have been developed...