...contrast to the acute immune responses that eliminate early stage cancer cells, chronic inflammatory responses...types of immune cells. Dendritic cells (DCs) are particularly popular whole cell therapeutics because they...clinical trials, expansion of participants based on early results can enhance the positive effects of the ...cell deaths that help activate tumor responses. Similarly, some radiotherapies have caused increased death...

... pic.twitter.com/drNBUdlQco — The Tarling-Vallim Lab (@TarlingVallim) December 19, 2020 In third place...post shared by Hannah Drury (@druryhannah) The Tarling-Vallim Lab’s first place-winning entry doubled ...

... of Ebola representing the latest outbreak and earlier ones, along with links to the relevant scientific... and The New England Journal of Medicine have similarly curated their Ebola-related content. -And the ... in EBOV’s past, present, and future, don’t miss Carl Zimmer’s coverage on the subject in the New York...

...scientific or scholarly research contributions in the field Evidence of authorship of scholarly books or articles...benefit from the applicant thinking about the process early, keeping good records, and planning for the route... articles (in scholarly journals with international circulation) in the field EB-1Bs historically have...

... that 20% of tagged proteins did not localize similarly to their untagged counterparts. These findings... for examining protein-protein interactions, particularly in single-molecule or high-throughput applications...methods (2015). PubMed PMID:26322837. 2. Stadler, Charlotte, et al. "Immunofluorescence and fluorescent-protein...

...organization/position exist yet?", you are in the early stages of creating an opportunity. That's how Addgene...Director of Science Product Management “I knew very early on that I wanted to be an artist/designer. But there...each one.  Get the toughest steps out of the way early if you can.” - Eddy Page, Digital Media Production...

...number of out of office responses I’ve received). Clearly we have all of our writers to thank for the excellent...who wrote this month’s most popular blog post on early user experiences with CRISPR alternative, NgAgo....having trouble, to determine if there have been any early successes, and to find out what delivery techniques...

...reinventing the wheel is inefficient. An effective team regularly seeks expertise wherever it can be found. Listen...allies" – these are employees in your group that regularly step up to give feedback and fill you in on percolating...constructive input from your team: Solicit feedback regularly and often A one-time event doesn't work to get...

...the directory does not typically come out until nearly the last minute when all other options have been... phage alerts can be sent out to the directory earlier, but the researchers in the directory are volunteering...time and resources and there is a chance that an early request for phage may not be needed if other antibiotics...

...resulting in “negative data” often dominate the early years of a project. Dissemination of the knowledge...selection of data found in full-length publications. As early career researchers, we wondered how we could make... guest blogger Girija Goyal! Girija Goyal is an early career researcher and cofounded ReFigure with Joe...

...biological blockbuster known as the CRISPR (clustered regularly interspaced palindromic repeats) Cas (CRISPR associated...have been identified that neutralize CRISPR/Cas. Earlier this year, expression of 1 of 5 anti-CRISPR genes... Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM. Science. 2013 Jan;  ...

...began to study other extrachromosomal particles, particularly Resistance or R-factors. Like F-factors, R-factors...napkins to notebooks Although discovered in the early 1950s, it took until the 1970s for plasmids to gain...Stanley Falkow, Stanley Cohen, Herbert Boyer, and Charles Brinton concocted a wild idea of using the newly...

...miLab, a Boston-based startup focused on empowering early-stage scientists. You can think of miLab as a sort... next generation companies.  We launched in the early spring of 2015 and since that time have received...capital for such a fund is an impossibility at our early stage.  After each pitch we made, we considered ...

... a look at the blog ‘Scholarly Kitchen’ for a glimpse into the world of scholarly publishing. And see ...developing a career Developmental biology caught me early on: a simple egg is packed with information. I am...

... cats, Harley and Lexi, and a clutter ofoutdoors-only spiders, all of whom are named Charlotte, all of...technique was feasible, three separate things happened nearly simultaneously: The Wellcome Trust funded a center...

...original 2013 gene editing paper on CRISPR/Cas amassed nearly 2,400 citations in its first four years (1). In... over 6,500 requests for these plasmids. While clearly an outlier, this story had us wondering: is there...at the MIT Sloan School of Management. She is particularly interested in exploring how innovative tools...

...that, for many groups, may not be worthwhile. Particularly if in the end all they want to do is to quickly...size of the SpCas9 nuclease (~4.2 kb) this is a particularly prominent problem in CRISPR genome editing experiments...ready-to-use lentiviral preps. Each library uses nearly 80,000 gRNAs to target around 20,000 individual...

...assignee and this is a recipe for bad outcomes. Clearly articulate the desired outcomes. Begin with the... the heart of delegating for success.  Meet regularly before during and after the assignment to discuss...calendar even if it is just 15 minutes a week. Clearly identify constraints and boundaries. Where are ...

...and a friend. George Church runs his lab fairly similarly to his advisor Wally Gilbert: “Very interdisciplinary...Institute (HHMI) offers some great resources for Early Career Scientists, including their "Making the Right... EMBO Lab Leadership Courses HHMI Resources for Early Career Scientists Science Careers: Running Your ...

...antibody companies or check the literature. Pro tip! Early gates, like your live/dead markers or commonly used...isotype controls An isotype sample is prepared very similarly to a FMO sample: you make a sample from a combined...immunotherapies. She is currently a research technician in Arlene Sharpe's lab at Harvard Medical School.   More...