Improving Transduction Efficiency with Exosome AAVs
Type
Blog Post
...vector production, assembled AAV vector particles accumulate inside the producer cells and purification protocols...gradients. The current purification protocols for isolating exo-AAVs rely on differential centrifugation steps...Figure 2).
Since the development of the exo-AAV isolation protocol by Maguire and colleagues, other researchers...et al., 2017), and exo-AAV8 expressing human coagulation factor IX in liver in a mouse model of Haemophilia...et al. 2018).
The structure of exosome AAVs is related to the use of microvesicles as a vehicle for drug...