We narrowed to 48 results for: hyper

1. mTOR Pathway

   Type

   Collection

   ...mutations in negative regulators of mTORC1. The hyperactivation of mTORC1 in cancer promotes the conditions...

2. CRISPR Plasmids - Mammalian Expression

   Type

   Collection

   ...recruit a cytidine deaminase and induce somatic hypermutation in a 100 bp window. This technique creates diverse...

3. 27 Hot Plasmids from 2016

   Type

   Blog Post

   ...binding sites, which then recruit an MS2-fused hyperactive variant of activation-induced cytidine deaminase...deaminase (AID). AID normally mediates somatic hypermutation to generate diverse antibodies; in the CRISPR-X...

4. The 12 Days of CRISPR: 2021

   Type

   Blog Post

   ... gave to me: efficient CRISPR editing with a hypercompact Cas12f1 and engineered guide RNAs. On the sixth...

5. Future of Research Conference - Remarkable Opening Session

   Type

   Blog Post

   ...dire:  The current system is unsustainable, hypercompetition is corroding values, we are shifting away ...

6. Hot Plasmids and Viral Preps - September 2021

   Type

   Blog Post

   ...proteins found in the metagenome datasets from hypersaline samples, were engineered and adapted for RNAi...

7. Another Pathway into Cells: iTOP

   Type

   Blog Post

   ...editing. The small molecule NSDB and Na+ hypertonicity are key elements of iTOP. iTOP can be used to...

8. Cancer, Inflammation and Immunity - Harnessing the Body’s Defenses to Fight Cancer

   Type

   Blog Post

   ...from a state of chronic hepatitis caused by hypernutrition and alcohol consumption. Chronic inflammation...

9. RaPID Detection of RNA-protein Interactions

   Type

   Blog Post

   ...affect protein binding patterns. Hereditary Hyperferritinemia-Cataract Syndrome (HHCS), a disease characterized...

10. Antibodies 101: Secondary Antibodies

    Type

    Blog Post

    ...primary antibody without interfering with the hypervariable region, where an antibody binds to its target...

11. What's New in CRISPR - November 2021

    Type

    Blog Post

    ...CasMINI plasmids Efficient CRISPR editing with a hypercompact Cas12f1 and engineered guide RNAs Yong-Sam Kim...

12. Working with Nuclear Receptors

    Type

    Blog Post

    ... multitude of therapeutic indices, including hypertension, cancer, diabetes, cardiovascular disease, cholesterol...

13. Viral Vectors 101: Chemogenetics

    Type

    Blog Post

    ...such as the glycine receptor, will promote hyperpolarization. PSAM ligands The advantage of PSAMs lies ...

14. Reaching out to China: Canton Nucleic Acids Forum (CNAF) 2015

    Type

    Blog Post

    ...invasion.  His lab is studying P. furiosus, a hyperthermophile that exists in sea vents at the boiling point...

15. Illuminating Epigenetics with A FRET Based Biosensor

    Type

    Blog Post

    ...patterns, either large increases or decreases. Hypermethylation of CpG islands in the promoter region of tumor...

16. Plasmids 101: Protein Expression

    Type

    Blog Post

    ...optimized. Yeast cells are also known for hyperglycosylating proteins which may be an issue depending ...

17. CRISPR 101: RNA Editing with Cas13

    Type

    Blog Post

    ...editing. To increase A->G editing, they employed hyperactive ADAR constructs, like ADAR2DD(E488Q). They also...

18. CRISPR Between the Genes: How to Experiment with Enhancers and Epigenomics

    Type

    Blog Post

    ...luck, and always keep going. Appendix DNAse Hypersensitive Sites and Intergenic CRISPRs Yours truly generated...

19. Controlling for Off-target Effects with a New Genome-wide CRISPR Screen Design

    Type

    Blog Post

    ...sites that lack open chromatin marks, DNase hypersensitivity, or are in an enhancer, transcription factor...

20. Rett Syndrome: A History of Research and Therapeutic Outlooks

    Type

    Blog Post

    ...They introduced a mouse MECP2 guide RNA and a hyperactive version of the human RNA base editing enzyme ...