We narrowed to 51 results for: hyper

...spectrum of single-nucleotide variants (somatic hypermutation) in a larger editing window. These systems are...REPAIR , developed by the Feng Zhang lab , used a hyperactive adenosine deaminase that acts on RNA, ADAR2(E488Q...Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells. Nature Methods . 13 (12)...

...-dependent abasic site cleavage, and PARP1 hyperactivation, forming nuclear condensates that disrupt RNA...of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe. Science Advances...

...spectrum of single-nucleotide variants (somatic hypermutation) in a wider editing window, and are thus well...

...binding sites, which then recruit an MS2-fused hyperactive variant of activation-induced cytidine deaminase...deaminase (AID). AID normally mediates somatic hypermutation to generate diverse antibodies; in the CRISPR-X...

...mutations in negative regulators of mTORC1. The hyperactivation of mTORC1 in cancer promotes the conditions...

... gave to me: efficient CRISPR editing with a hypercompact Cas12f1 and engineered guide RNAs. On the sixth...

...dire:  The current system is unsustainable, hypercompetition is corroding values, we are shifting away ...

...proteins found in the metagenome datasets from hypersaline samples, were engineered and adapted for RNAi...

...editing. The small molecule NSDB and Na+ hypertonicity are key elements of iTOP. iTOP can be used to...

...from a state of chronic hepatitis caused by hypernutrition and alcohol consumption. Chronic inflammation...

...affect protein binding patterns. Hereditary Hyperferritinemia-Cataract Syndrome (HHCS), a disease characterized...

...primary antibody without interfering with the hypervariable region, where an antibody binds to its target...

...CasMINI plasmids Efficient CRISPR editing with a hypercompact Cas12f1 and engineered guide RNAs Yong-Sam Kim...

... multitude of therapeutic indices, including hypertension, cancer, diabetes, cardiovascular disease, cholesterol...

...such as the glycine receptor, will promote hyperpolarization. PSAM ligands The advantage of PSAMs lies ...

...invasion.  His lab is studying P. furiosus, a hyperthermophile that exists in sea vents at the boiling point...

...patterns, either large increases or decreases. Hypermethylation of CpG islands in the promoter region of tumor...

...optimized. Yeast cells are also known for hyperglycosylating proteins which may be an issue depending ...

...editing. To increase A->G editing, they employed hyperactive ADAR constructs, like ADAR2DD(E488Q). They also...

...luck, and always keep going. Appendix DNAse Hypersensitive Sites and Intergenic CRISPRs Yours truly generated...