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Showing: 21 - 40 of 48 results

  1. Technologies Enabled by NanoLuc® Luciferase

    Type
    Blog Post
    ...photoactivatable, optogenetic accuators to depolarize or hyperpolarize membranes. Traditional FRET reporters could ...depolarization increases the BRET signal whereas hyperpolarization decreases the signal. The authors additionally...

  2. A Primer on Optogenetics: Introduction and Opsin Delivery

    Type
    Blog Post
    ...results in efflux of chloride ions, subsequent hyperpolarization, and inhibition of action potential generation...spectrum as HR and also results in membrane hyperpolarization but unlike HR, this is achieved through hydrogen...

  3. 27 Hot Plasmids from 2016

    Type
    Blog Post
    ...binding sites, which then recruit an MS2-fused hyperactive variant of activation-induced cytidine deaminase...deaminase (AID). AID normally mediates somatic hypermutation to generate diverse antibodies; in the CRISPR-X...

  4. The 12 Days of CRISPR: 2021

    Type
    Blog Post
    ... gave to me: efficient CRISPR editing with a hypercompact Cas12f1 and engineered guide RNAs. On the sixth...

  6. Another Pathway into Cells: iTOP

    Type
    Blog Post
    ...cell editing. The small molecule NSDB and Na+ hypertonicity are key elements of iTOP. iTOP can be used to...

  10. Working with Nuclear Receptors

    Type
    Blog Post
    ... multitude of therapeutic indices, including hypertension, cancer, diabetes, cardiovascular disease, cholesterol...
Showing: 21 - 40 of 48 results