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...sometimes we benefit and sometimes we don't."     - Jennifer Tsang, Science Communications and Marketing Coordinator...

... Jennifer Tsang...

... Jennifer Tsang...

...There are many different flavors of MTAs, but the Uniform Biological Material Transfer Agreement (UBMTA) ...

...in the disease. For example, very few diseases manifest as a single mutation or expression dysregulation...

...resolvable compact identifiers, which are Compact Uniform Resource Identifiers (CURIEs) combined with well-established...

...meeting shared plenty of details, but they also uniformly stepped back to give a big picture perspective...

... Jennifer Tsang...

...efficiency; where shRNA treatment produced 500-900 significant off-targets, CasRx displayed zero. Unlike Cas9...

...result, how most of these “variants of unknown significance” (sometimes called “VUS”) function is unknown...

...let’s explain what kind of assays can be used to sniff out your desired mutations. The assays you will ...

...Homogenization for a tissue sample can also need significant optimization for the sample type and size.) It...

...is highly specific in mammalian cells without significant off-target effects, yet small enough to be packaged...

...you're trapped in a pattern of small errors that significantly impacts your experiments. What do you do when...

...activity relative to Cas9. Since then, the Joung and Jennifer Doudna Labs used targeted mutagenesis to generate...

... Jennifer Tsang...

... Jennifer Tsang...

...solve the problem: CasPEDIA, a new resource from Jennifer Doudna’s lab at the Innovative Genomics Institute...

... technologies have idiosyncrasies presents a significant barrier for those wishing to use it as a tool...

...originally written by Leila Haery in 2017 and significantly updated in 2023 by Jason Nasse.  References...