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Splicing-targeting CRISPR-Cas9 library for human lncRNAs

Pooled Library

#119977

Purpose

The CRISPR sgRNA library was designed to target the 5' or 3' splice sites of lncRNAs in genome-scale, in order to knockout the targeted lncRNAs.

Depositor

Wensheng Wei

Article

Liu et al Nat Biotechnol. 2018 Nov 5. pii: nbt.428

Expression

Mammalian

Species

Homo sapiens

Use

CRISPR and Lentiviral

Available since

March 27, 2019

Availability

Academic Institutions and Nonprofits only
PB-EF1a-Puro-V8.2

Pooled Library

#178943

Purpose

Barcoding library for the macsGESTALT inducible lineage recording system

Depositor

Christopher Lengner

Article

Simeonov et al Cancer Cell. 2021 Aug 9;39(8):1150-1162.

Expression

Mammalian

Available since

March 22, 2022

Availability

Academic Institutions and Nonprofits only
Human SAM library in lenti sgRNA(MS2)_puro backbone

Pooled Library

#1000000074

Purpose

Genome-wide CRISPR gRNA pooled library for activation of mouse genes

Depositor

Feng Zhang

Available since

March 17, 2016

Availability

Academic Institutions and Nonprofits only
Human messenger-RBP sgRNA library

Pooled Library

#168791

Purpose

CRISPR library targets sub-pool of human mRNA binding proteins

Depositor

Martin Turner

Article

Turner et al CRISPR J. 2021 Jun;4(3):427-437. doi: 10

Expression

Mammalian

Species

Homo sapiens

Use

CRISPR and Lentiviral

Available since

July 30, 2021

Availability

Academic Institutions and Nonprofits only
Mouse Brie kinome pooled library, guides 1-4 in lentiGuide-Puro backbone

Pooled Library

#75316

Purpose

Mouse sgRNA library in backbone lentiGuide-Puro targeting 713 kinase genes and containing 2,852 unique sgRNAs along with 100 non-targeting controls

Depositor

David Root, John Doench

Article

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Available since

June 27, 2016

Availability

Academic Institutions and Nonprofits only
hCRISPRa-v2, Gene Expression (h5), top 5 sgRNAs/gene

Pooled Library

#83984

Purpose

Human CRISPRa Pooled Library targeting gene expression

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
Perturb-seq GBC library

Pooled Library

#85968

Purpose

Perturb-seq GBC library

Depositor

Jonathan Weissman

Article

Adamson et al Cell. 2016 Dec 15;167(7):1867-1882.e21.

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

Feb. 14, 2017

Availability

Academic Institutions and Nonprofits only
Human Cas13 Pooled Long-Noncoding RNA (lncRNA) Library

Pooled Library

#227014

Purpose

CRISPR-Cas13 lentiviral pooled library targeting human lncRNAs and their closest protein-coding genes for transcriptome-wide knockdown screens.

Depositor

Neville Sanjana

Expression

Mammalian

Species

Homo sapiens

Use

CRISPR and Lentiviral

Available since

Feb. 11, 2025

Availability

Academic Institutions and Nonprofits only
Mouse Base Editing Sensor Library

Pooled Library

#179217

Purpose

sgRNAs that target frequently occurring cancer associated mutations identified in the MSK IMPACT dataset that can be modeled with cytosine base editing.

Depositor

Lukas Dow

Article

Sanchez-Rivera et al Nat Biotechnol. 2022 Feb 14. pii: 10.103

Expression

Mammalian

Use

Lentiviral

Available since

June 16, 2022

Availability

Academic Institutions and Nonprofits only
p11-3’_8xN_PAM-site1 (RTW554)

Pooled Library

#160132

Purpose

Plasmid library harboring a randomized 8nt PAM 3’ of target site 1. Can be used to profile CRISPR-Cas PAM requirements of enzymes that recognize 3’ PAMs (e.g. Cas9)

Depositor

Benjamin Kleinstiver, Keith Joung

Article

Walton et al Nat Protoc. 2021 Feb 5. pii: 10.1038/s41

Species

Synthetic

Use

CRISPR

Available since

Feb. 8, 2021

Availability

Academic Institutions and Nonprofits only
Mouse Brie kinome pooled library, guides 1-4 in lentiCRISPRv2 backbone

Pooled Library

#75317

Purpose

Mouse sgRNA library in backbone lentiCRISPRv2 targeting 713 kinase genes and containing 2,852 unique sgRNAs along with 100 non-targeting controls

Depositor

David Root, John Doench

Article

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Available since

June 27, 2016

Availability

Academic Institutions and Nonprofits only
Barcode Library 1 (BCL1)

Pooled Library

#179852

Purpose

Lentiviral barcode library that consists of 10^6 unique barcodes. Barcodes consist of 12bp degenerate region followed by two stable bases (C or G) and 4bp unique library code CCAA.

Depositor

Jason Moffat

Article

Rehman et al Cell. 2021 Jan 7;184(1):226-242.e21. doi

Expression

Mammalian

Use

Lentiviral

Available since

May 12, 2022

Availability

Academic Institutions and Nonprofits only
Mouse sgRNA library Gouda in pRDA_118 backbone

Pooled Library

#136987

Purpose

Expresses sgRNAs targeting mouse genes

Depositor

John Doench

Article

DeWeirdt et al Nat Commun. 2020 Feb 6;11(1):752. doi: 1

Expression

Mammalian

Species

Mus musculus

Use

CRISPR and Lentiviral

Available since

Feb. 24, 2020

Availability

Academic Institutions and Nonprofits only
RLC12

Pooled Library

#163954

Purpose

RLC12 pooled library

Depositor

Jeremy Rock

Article

Bosch et al Cell. 2021 Jul 16. pii: S0092-8674(21)00

Expression

Bacterial

Use

CRISPR

Available since

Oct. 1, 2021

Availability

Academic Institutions and Nonprofits only
Mouse CRISPRa sgRNA library Caprano in backbone XPR_502 (P65 HSF), Set A

Pooled Library

#92383

Purpose

CRISPRa

Depositor

David Root, John Doench

Article

Sanson et al Nat Commun. 2018 Dec 21;9(1):5416. doi:

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

July 13, 2018

Availability

Academic Institutions and Nonprofits only
Mouse messenger-RBP sgRNA library

Pooled Library

#169082

Purpose

CRISPR library targeting mouse genes

Depositor

Martin Turner

Article

Turner et al eLife. 2022 Apr 22;11. pii: 72313. doi:

Expression

Mammalian

Species

Mus musculus

Use

CRISPR and Lentiviral

Available since

Sept. 10, 2021

Availability

Academic Institutions and Nonprofits only
Human genome-wide lentiviral CRISPR gRNA library version 1

Pooled Library

#67989

Purpose

Human genome-wide CRISPR guide RNA library V1 (pKLV2-U6gRNA5(HumanV1)-PGKpuro2ABFP-W)

Depositor

Kosuke Yusa

Article

Tzelepis et al Cell Rep. 2016 Oct 18;17(4):1193-1205. d

Species

Homo sapiens, Mus musculus, and Synthetic

Use

CRISPR and Lentiviral

Available since

Oct. 14, 2016

Availability

Academic Institutions and Nonprofits only
Human SLC SAM Library

Pooled Library

#132561

Purpose

Expresses gRNAs for activation of human Solute Carrier family genes

Depositor

Giulio Superti-Furga

Article

Rebsamen et al Life Sci Alliance. 2022 Sep 16;5(11):e20

Expression

Mammalian

Species

Homo sapiens

Use

CRISPR and Lentiviral

Available since

May 18, 2020

Availability

Academic Institutions and Nonprofits only
SPLINTR BFP v1

Pooled Library

#179776

Purpose

SPLINTR (Single-cell Profiling and LINeage TRacing) is a high diversity lentiviral barcode library for tracing clonal lineages using bulk and single-cell readouts.

Depositor

Mark Dawson

Article

Fennell et al Nature. 2022 Jan;601(7891):125-131. doi:

Expression

Mammalian

Use

Lentiviral

Available since

May 11, 2022

Availability

Academic Institutions and Nonprofits only
mCRISPRa-v2, Cancer and Apoptosis (m2), top 5 sgRNAs/gene

Pooled Library

#83999

Purpose

Mouse CRISPRa Pooled Library targeting cancer and apoptosis genes

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
hCRISPRa-v2, Cancer and Apoptosis (h2), top 5 sgRNAs/gene

Pooled Library

#83981

Purpose

Human CRISPRa Pooled Library targeting cancer and apoptosis genes

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
Human Brunello kinome pooled library, guides 1-8 in lentiGuide-Puro backbone

Pooled Library

#1000000082

Purpose

CRISPR gRNA knockout pooled library for targeting the human kinome

Depositor

David Root, John Doench

Available since

June 27, 2016

Availability

Academic Institutions and Nonprofits only
hCRISPRa-v2, Mitochondria, Trafficking, and Motility (h4), top 5 sgRNAs/gene

Pooled Library

#83983

Purpose

Human CRISPRa Pooled Library targeting Mitochondria, Trafficking, and Motility genes

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
Drosophila_sgRNA_group_3

Pooled Library

#134584

Purpose

Targets all other Drosophila genes not included in Groups 1 and 2

Depositor

Norbert Perrimon

Article

Viswanatha et al Elife. 2018 Jul 27;7. pii: 36333. doi: 1

Expression

Insect

Species

Drosophila melanogaster

Use

CRISPR

Available since

Feb. 25, 2020

Availability

Academic Institutions and Nonprofits only
Drosophila_sgRNA_group_2

Pooled Library

#134583

Purpose

Targets Drosophila orthologs of vertebrate genes that have undergone expansion in the vertebrate line

Depositor

Norbert Perrimon

Article

Viswanatha et al Elife. 2018 Jul 27;7. pii: 36333. doi: 1

Expression

Insect

Species

Drosophila melanogaster

Use

CRISPR

Available since

Feb. 25, 2020

Availability

Academic Institutions and Nonprofits only
Drosophila_sgRNA_group_1

Pooled Library

#134582

Purpose

Targets kinases, phosphatases, and Drosophila orthologs of drug targets

Depositor

Norbert Perrimon

Article

Viswanatha et al Elife. 2018 Jul 27;7. pii: 36333. doi: 1

Expression

Insect

Species

Drosophila melanogaster

Use

CRISPR

Available since

Feb. 25, 2020

Availability

Academic Institutions and Nonprofits only
Human CRISPR lncRNA activation library (SAM) in lenti sgRNA(MS2)_zeo backbone

Pooled Library

#1000000106

Purpose

Human CRISPR Synergistic Activation Mediator (SAM) pooled library for the transcriptional activation of lncRNAs

Depositor

Feng Zhang

Available since

June 5, 2017

Availability

Academic Institutions and Nonprofits only
mCRISPRa-v2, Gene Expression (m5), top 5 sgRNAs/gene

Pooled Library

#84002

Purpose

Mouse CRISPRa Pooled Library targeting gene expression

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
hCRISPRa-v2, Stress and Proteostasis (h3), top 5 sgRNAs/gene

Pooled Library

#83982

Purpose

Human CRISPRa Pooled Library targeting stress and proteostasis genes

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
hCRISPRa-v2, Unassigned (h7), top 5 sgRNAs/gene

Pooled Library

#83986

Purpose

Human CRISPRa Pooled Library targeting unassigned genes

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
Bassik lab Mouse CRISPR-Cas9 Deletion Library - Unassigned1

Pooled Library

#1000000127

Purpose

CRISPR gRNA mouse knockout pooled library - Unassigned1

Depositor

Michael Bassik

Available since

May 23, 2018

Availability

Academic Institutions and Nonprofits only
Bassik lab Mouse CRISPR-Cas9 Deletion Library - Unassigned2

Pooled Library

#1000000128

Purpose

CRISPR gRNA mouse knockout pooled library - Unassigned2

Depositor

Michael Bassik

Available since

May 23, 2018

Availability

Academic Institutions and Nonprofits only
mCRISPRa-v2, Mitochondria, Trafficking, and Motility (m4), top 5 sgRNAs/gene

Pooled Library

#84001

Purpose

Mouse CRISPRa Pooled Library targeting Mitochondria, Trafficking, and Motility genes

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
mCRISPRa-v2, Stress and Proteostasis (m3), top 5 sgRNAs/gene

Pooled Library

#84000

Purpose

Mouse CRISPRi Pooled Library targeting stress and proteostasis genes

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
mCRISPRa-v2, Unassigned (m7), top 5 sgRNAs/gene

Pooled Library

#84004

Purpose

Mouse CRISPRa Pooled Library targeting unassigned genes

Depositor

Jonathan Weissman

Article

Horlbeck et al Elife. 2016 Sep 23;5. pii: e19760. doi:

Available since

Jan. 12, 2017

Availability

Academic Institutions and Nonprofits only
Bassik lab Mouse CRISPR-Cas9 Deletion Library - Mouse unique 2

Pooled Library

#1000000130

Purpose

CRISPR gRNA mouse knockout pooled library - Mouse Unique2

Depositor

Michael Bassik

Available since

May 23, 2018

Availability

Academic Institutions and Nonprofits only
Bassik lab Mouse CRISPR-Cas9 Deletion Library - Mouse unique 1

Pooled Library

#1000000129

Purpose

CRISPR gRNA mouse knockout pooled library - Mouse Unique1

Depositor

Michael Bassik

Available since

May 23, 2018

Availability

Academic Institutions and Nonprofits only
Human Brunello kinome pooled library, guides 1-4 in lentiCRISPRv2 backbone

Pooled Library

#75314

Purpose

Human sgRNA library in backbone lentiCRISPRv2 targeting 763 kinase genes and containing 3,052 unique sgRNAs along with 100 non-targeting controls

Depositor

David Root, John Doench

Article

Doench et al Nat Biotechnol. 2016 Jan 18. doi: 10.103

Expression

Mammalian

Use

CRISPR and Lentiviral

Available since

June 27, 2016

Availability

Academic Institutions and Nonprofits only
Synuclein VHH Immune Library

Pooled Library

#1000000071

Purpose

Synuclein phagemid VHH phage display library

Depositor

Anne Messer, Michael J Fox Foundation MJFF

Available since

June 14, 2016

Availability

Industry, Academic Institutions, and Nonprofits
TP53 MITE Library

Pooled Library

#113569

Purpose

Pooled lentiviral plasmid library containing ~8,000 single amino acid substitution and nonsense mutant variants of p53

Depositor

David Root, William Hahn

Article

Giacomelli et al Nat Genet. 2018 Oct;50(10):1381-1387. do

Expression

Mammalian

Species

Homo sapiens

Use

Lentiviral

Available since

Jan. 4, 2019

Availability

Academic Institutions and Nonprofits only

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