Fluorescent Proteins: Activity Regulation

Background

Fluorescent proteins such as GFP have long been used for labeling, but new methods are emerging to use these fluorescent proteins to modulate biological activity. Early tools allow scientists to regulate transcription, and additional tools are being developed to regulate a variety of other activities. By using GFP as a scaffold, scientists can design de novo systems using modular components or take advantage of existing GFP-lines for cell-specific manipulation.

Plasmids

Fluorescent Protein	Purpose	Principal Investigator	Plasmids
GFP	GFP-dependent transcription factors	Connie Cepko	See Plasmids
Dronpa	Optical control of protein activity	Michael Lin	See Plasmids