Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40.
Zhang D, Yue T, Choi JH, Nair-Gill E, Zhong X, Wang KW, Zhan X, Li X, Choi M, Tang M, Quan J, Hildebrand S, Moresco EMY, Beutler B
Nat Immunol. 2019 Oct;20(10):1322-1334. doi: 10.1038/s41590-019-0464-4. Epub 2019 Aug 19. PubMed Article
Zhang D, Yue T, Choi JH, Nair-Gill E, Zhong X, Wang KW, Zhan X, Li X, Choi M, Tang M, Quan J, Hildebrand S, Moresco EMY, Beutler B
Nat Immunol. 2019 Oct;20(10):1322-1334. doi: 10.1038/s41590-019-0464-4. Epub 2019 Aug 19. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 134249 | pBOB-N-Flag-Snrnp40 | Lentivector encoding Flag-tagged Snrnp40 |
| 134250 | pBOB-N-Flag-Snrnp40-skywarp | Lentivector encoding Flag-tagged skywarp form of Snrnp40 (missing exon 5) |
| 134251 | pLV-Hyg-Snrnp40-CRISPR-resistant | Lentivector encoding CRISPR-resistant Snrnp40 |
| 134252 | pLV-Hyg-Snrnp40-skywarp-CRISPR-resistant | Lentivector encoding CRISPR-resistant skywarp form of Snrnp40 (missing exon 5) |
| 134253 | pLV-puro-N-Flag-Snrnp40 | Lentivector encoding Flag-tagged Snrnp40 |
| 134254 | pLV-puro-N-Flag-h-SNRNP40 | Lentivector encoding Flag-tagged human SNRNP40 |
| 134255 | lentiCRISPRv2-Snrnp40 | Lentivector for Snrnp40 CRISPR knockout |