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Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.
Maiuri T, Mocle AJ, Hung CL, Xia J, van Roon-Mom WM, Truant R
Hum Mol Genet. 2016 Dec 25. pii: ddw395. doi: 10.1093/hmg/ddw395.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
97424nucHCB1Nuclear Huntingtin Chromobody 1: "Happ1" intrabody recognizing amino acids 41–81 of huntingtin, fused to eYFP and nuclear localization signal.
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98581nucHCB2Nuclear Huntingtin Chromobody 2: "iVHH4" intrabody recognizing amino acids 49–148 of huntingtin, fused to eYFP and nuclear localization signal.
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98582HCB1Huntingtin Chromobody 1: "Happ1" intrabody recognizing amino acids 41–81 of huntingtin, fused to eYFP.
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98583HCB2Huntingtin Chromobody 2: "iVHH4" intrabody recognizing amino acids 49-148 of huntingtin, fused to eYFP.
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Antibodies from Article