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SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM
Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
72880SHMT2-RESoverexpression
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72881mGLDCoverexpression
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72882GLDC-RESoverexpression
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72883shGLDC-DOXdox inducible knockdown
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72885sgGCAT_2CRISPR-Cas9 induced gene disruption
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72886sgGLDC_1CRISPR-Cas9 induced gene disruption
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72887sgGLDC_2CRISPR-Cas9 induced gene disruption
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Antibodies from Article