The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 T Cells.
Martinez GJ, Pereira RM, Aijo T, Kim EY, Marangoni F, Pipkin ME, Togher S, Heissmeyer V, Zhang YC, Crotty S, Lamperti ED, Ansel KM, Mempel TR, Lahdesmaki H, Hogan PG, Rao A
Immunity. 2015 Feb 6. pii: S1074-7613(15)00032-1. doi: 10.1016/j.immuni.2015.01.006. PubMed Article
Martinez GJ, Pereira RM, Aijo T, Kim EY, Marangoni F, Pipkin ME, Togher S, Heissmeyer V, Zhang YC, Crotty S, Lamperti ED, Ansel KM, Mempel TR, Lahdesmaki H, Hogan PG, Rao A
Immunity. 2015 Feb 6. pii: S1074-7613(15)00032-1. doi: 10.1016/j.immuni.2015.01.006. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 63214 | CA-RIT-NFAT1 (PGK-Puro) | Constitutively active NFAT1, mutated to interfere selectively with the NFAT:AP-1 interactio. Contains Puromycin selection marker |
| 63669 | DBDmut-CA-RIT-NFAT1 | Constitutively active NFAT1 and also unable to interact with AP-1 with four point mutations in the DNA binding loop that abolish DNA binding |
| 85181 | CA-RIT-NFAT1 (IRES-GFP) | Constitutively active NFAT1, mutated to interfere selectively with the NFAT:AP-1 interaction. Co-expresses EGFP for selection |