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Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM
Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. PubMed Article

Plasmids from Article

ID Plasmid Purpose
71855pRK5-FLAG-SLC38A9.1overexpression
71858pLJM60-FLAG-SLC38A9.1lentiviral stable expression
71861pLJM60-FLAG-SLC38A9.1 (delta110)lentiviral stable expression
71862pLJM60-FLAG-SLC38A9.1 (1-119aa)lentiviral stable expression
71863pLJM60-FLAG-SLC38A9.1 H60Alentiviral stable expression
71864pLJM60-FLAG-SLC38A9.1 I68Alentiviral stable expression
71865pLJM60-FLAG-SLC38A9.1 Y71Alentiviral stable expression
71866pLJM60-FLAG-SLC38A9.1 L74Alentiviral stable expression
71867pLJM60-FLAG-SLC38A9.1 P90Alentiviral stable expression
71868pRK5-LAMP1-FLAGoverexpression
71869pRK5-HA-SLC38A9.1overexpression

Antibodies from Article