Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis.
Li X, Wirtz T, Weber T, Lebedin M, Lowenstein ED, Sommermann T, Zach A, Yasuda T, de la Rosa K, Chu VT, Schulte JH, Muller I, Kocks C, Rajewsky K
Sci Immunol. 2024 Feb 2;9(92):eadi0042. doi: 10.1126/sciimmunol.adi0042. Epub 2024 Feb 2.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 209073 | pDonor-Prf1-ires-mCherry | Targeting vector for the mouse Prf1 locus to correct prf1 gene |
| 209074 | pDonor-Prf1-mock-ires-mCherry | Targeting vector for the mouse Prf1 locus to correct prf1 gene |
| 209075 | pDonor-PRF1-Exon3 | Targeting vector for the human PRF1 locus to replace exon 3 with repaired exon 3 |
| 209076 | pDonor-PRF1-T2A-cDNA | Targeting vector for the human PRF1 locus to replace exon 3 with repaired cDNA |