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Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate.

Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock BA, Jaffe JD, Haigis MC, Beroukhim R, Signoretti S, Koivunen P, Kaelin WG Jr
Science. 2019 Mar 15;363(6432):1217-1222. doi: 10.1126/science.aaw1026. Epub 2019 Mar 14. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
203578pLX304-ARNTExpresses wild-type ARNT in mammalian cells.
203579pLX304-ARNT-d414Expresses a functionally inactive version of ARNT with 5’ 414 bp deletion [Δ414] in mammalian cells.
203580pLX304-KDM6AExpresses wild-type KDM6A in mammalian cells.

Antibodies from Article