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Covalent S-Adenosylhomocysteine-Based DNA Methyltransferase 2 Inhibitors with a New Type of Aryl Warhead.

Schwickert M, Zimmermann RA, Habeck T, Hoba SN, Nidoieva Z, Fischer TR, Stark MM, Kersten C, Lermyte F, Helm M, Schirmeister T
ACS Med Chem Lett. 2023 May 9;14(6):777-787. doi: 10.1021/acsmedchemlett.3c00062. eCollection 2023 Jun 8. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
198382DNMT2Δ191-237Bacterial expression plasmid for human DNMT2 deletion mutant; for binding assays

Antibodies from Article