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BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors.

Sevdali E, Block V, Lataretu M, Li H, Smulski CR, Briem JS, Heitz Y, Fischer B, Ramirez NJ, Grimbacher B, Jack HM, Voll RE, Holzer M, Schneider P, Eibel H
Cell Rep. 2022 Jun 28;39(13):111019. doi: 10.1016/j.celrep.2022.111019. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
187002pNL-CEF-BAFFR-CFPExpression of human BAFFR-CFP fusion protein
187003pNL-CEF-CD79A-RFPExpression of human CD79A as RFP fusion protein
187004pNL-CEF-CD79A-YFPExpression of human CD79A as YFP fusion protein
187005pNL-CEF-CD79B-RFPExpression of human CD79B as RFP fusion protein
187006pNL-CEF-CD79B-YFPExpression of human CD79B as YFP fusion protein
187007pNL-CEF-IgA1-IRES-GFPExpression of human anti-SARS-CoV-2 S Protein Wuhan-Hu1 IgA1
187008pNL-CEF-IgG1-IRES-GFPExpression of human anti-SARS-CoV-2 S Protein Wuhan-Hu1 IgG1
187009pNL-CEF-IgA1Expression of human anti-SARS-CoV-2 S Protein Wuhan-Hu1 IgA1
187010pNL-CEF-IgG1Expression of human anti-SARS-CoV-2 S Protein Wuhan-Hu1 IgG1
187011pNL-CEF-IgM-IRES-GFPExpression of human anti-SARS-CoV-2 S Protein Wuhan-Hu1 IgM
187013pNL-CEF-IgMExpression of human anti-SARS-CoV-2 S Protein Wuhan-Hu1 IgM

Antibodies from Article