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IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.

Prelli Bozzo C, Nchioua R, Volcic M, Koepke L, Kruger J, Schutz D, Heller S, Sturzel CM, Kmiec D, Conzelmann C, Muller J, Zech F, Braun E, Gross R, Wettstein L, Weil T, Weiss J, Diofano F, Rodriguez Alfonso AA, Wiese S, Sauter D, Munch J, Goffinet C, Catanese A, Schon M, Boeckers TM, Stenger S, Sato K, Just S, Kleger A, Sparrer KMJ, Kirchhoff F
Nat Commun. 2021 Jul 28;12(1):4584. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
179955pCG_IFITM1Expression vector for human IFITM1.
179956pCG_IFITM2Expression vector for human IFITM2.
179957pCG_IFITM3Expression vector for human IFITM3.
179958pCG_IFITM1-IRES_eGFPExpression vector for human IFITM1. Co-expresses GFP controlled by an IRES element.
179959pCG_IFITM2-IRES_eGFPExpression vector for human IFITM2. Co-expresses GFP controlled by an IRES element.
179960pCG_IFITM3-IRES_BFPExpression vector for human IFITM3. Co-expresses BFP controlled by an IRES element.

Antibodies from Article