A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer.
Lier S, Sellmer A, Orben F, Heinzlmeir S, Krauss L, Schneeweis C, Hassan Z, Schneider C, Schafer A, Pongratz H, Engleitner T, Ollinger R, Kuisl A, Bassermann F, Schlag C, Kong B, Dove S, Kuster B, Rad R, Reichert M, Wirth M, Saur D, Mahboobi S, Schneider G
Bioorg Chem. 2021 Nov 20:105505. doi: 10.1016/j.bioorg.2021.105505.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 166240 | lentiCRISPR v2 puro - CRBN (#1) | sgRNA (#1) to generate a knockout of human CRBN by targeting the middle region of Exon1 |
| 166241 | lentiCRISPR v2 puro - CRBN (#2) | sgRNA (#2) to generate a knockout of human CRBN by targeting the start region of Exon1 |