SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells.
Rebendenne A, Valadao ALC, Tauziet M, Maarifi G, Bonaventure B, McKellar J, Planes R, Nisole S, Arnaud-Arnould M, Moncorge O, Goujon C
J Virol. 2021 Jan 29. pii: JVI.02415-20. doi: 10.1128/JVI.02415-20.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 145839 | RRL.sin.cPPT.SFFV/Ace2.IRES-puro.WPRE (MT126) | Lentiviral vector genome to ectopically express human Ace2 |
| 145840 | RRL.sin.cPPT.SFFV/Ace2.IRES-neo.WPRE (MT129) | Lentiviral vector genome to ectopically express human Ace2 |
| 145842 | RRL.sin.cPPT.SFFV/Ace2.WPRE (MT136) | Lentiviral vector genome to ectopically express human Ace2 |
| 145843 | RRL.sin.cPPT.SFFV/TMPRSS2 (variant 1).IRES-neo.WPRE (MT130) | Lentiviral vector genome to ectopically express human TMPRSS2 variant 1 |