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Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40.

Zhang D, Yue T, Choi JH, Nair-Gill E, Zhong X, Wang KW, Zhan X, Li X, Choi M, Tang M, Quan J, Hildebrand S, Moresco EMY, Beutler B
Nat Immunol. 2019 Oct;20(10):1322-1334. doi: 10.1038/s41590-019-0464-4. Epub 2019 Aug 19. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
134249pBOB-N-Flag-Snrnp40Lentivector encoding Flag-tagged Snrnp40
134250pBOB-N-Flag-Snrnp40-skywarpLentivector encoding Flag-tagged skywarp form of Snrnp40 (missing exon 5)
134251pLV-Hyg-Snrnp40-CRISPR-resistantLentivector encoding CRISPR-resistant Snrnp40
134252pLV-Hyg-Snrnp40-skywarp-CRISPR-resistantLentivector encoding CRISPR-resistant skywarp form of Snrnp40 (missing exon 5)
134253pLV-puro-N-Flag-Snrnp40Lentivector encoding Flag-tagged Snrnp40
134254pLV-puro-N-Flag-h-SNRNP40Lentivector encoding Flag-tagged human SNRNP40
134255lentiCRISPRv2-Snrnp40Lentivector for Snrnp40 CRISPR knockout

Antibodies from Article