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Integrated genetic and pharmacologic interrogation of rare cancers.

Hong AL, Tseng YY, Cowley GS, Jonas O, Cheah JH, Kynnap BD, Doshi MB, Oh C, Meyer SC, Church AJ, Gill S, Bielski CM, Keskula P, Imamovic A, Howell S, Kryukov GV, Clemons PA, Tsherniak A, Vazquez F, Crompton BD, Shamji AF, Rodriguez-Galindo C, Janeway KA, Roberts CW, Stegmaier K, van Hummelen P, Cima MJ, Langer RS, Garraway LA, Schreiber SL, Root DE, Hahn WC, Boehm JS
Nat Commun. 2016 Jun 22;7:11987. doi: 10.1038/ncomms11987. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
78152TRCN0000297275shCDK4 targeting 3UTR
78153TRCN0000279887shCDK4 targeting CDS
78154TRCN0000279953shCDK4 targeting CDS
78155TRCN0000279952shCDK4 targeting 3UTR
78156TRCN0000338399shXPO1 targeting CDS
78157TRCN0000338401shXPO1 targeting CDS
78158TRCN0000338462shXPO1 targeting CDS
78159TRCN0000072213shRFP control
78160TRCN0000072225shLacZ control
78161TRCN0000072254Luciferase control
78162TRCN0000231737Luciferase control
78163TRCN0000231725shRFP control
78164sgTP53_3sgTP53
78165sgGFP_3sgGFP
78166pXPR_BRD111Expresses Cas9 with the pLX311 backbone

Antibodies from Article