Mutant lamin A links prophase to a p53 independent senescence program.
Moiseeva O, Lessard F, Acevedo-Aquino M, Vernier M, Tsantrizos YS, Ferbeyre G
Cell Cycle. 2015 Aug 3;14(15):2408-21. doi: 10.1080/15384101.2015.1053671. Epub 2015 Jun 1.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 69059 | pLPC-LaminA | encodes the lamin A protein |
| 69060 | pLPC-L647RLaminA | encodes a lamin A mutant with Leucine 647 mutated to an Arginin |
| 69061 | pLPC-Progerin | encodes the lamin A mutant with a 50 amino acids deletion responsible for the Hutchinson-Gilford Progeria Syndrome |
| 69062 | pLPC-L647RLaminA-CS | encodes a lamin A mutant with Leucine 647 mutated to an Arginin and with a substitution of cysteine in CaaX-motif by a serine |
| 69063 | pLPC-S22AProgerin-CS | encodes a Progerin mutant with serine 22 mutated to an alanine and with a substitution of cysteine in CaaX-motif by a serine |
| 69064 | pLPC-Progerin-CS | encodes Progerin with a substitution of cysteine in CaaX-motif by a serine |
| 69065 | pLPC-S22A-Progerin | encodes a Progerin mutant where serine 22 is mutated to an alanine |
| 69066 | pLPC-S22A-LaminA | encodes a mutant lamin A where serine 22 is mutated to a an alanine |
| 69067 | mLPx-shZMPSTE24 | encodes a shRNA against the protease ZMPSTE24 |