pKLV-U6gRNA(BbsI)-PGKpuro2ABFP Citations (81)
Originally described in: Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library.Koike-Yusa H, Li Y, Tan EP, Velasco-Herrera Mdel C, Yusa K Nat Biotechnol. 2014 Mar;32(3):267-73. doi: 10.1038/nbt.2800. Epub 2013 Dec 23. PubMed Journal
Articles Citing pKLV-U6gRNA(BbsI)-PGKpuro2ABFP
| Articles |
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Simultaneous live imaging of the transcription and nuclear position of specific genes.
Ochiai H, Sugawara T, Yamamoto T.
Nucleic Acids Res. 2015 Jun 19. pii: gkv624.
PubMed
Associated Plasmids |
| CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection. Wollebo HS, Bellizzi A, Kaminski R, Hu W, White MK, Khalili K. PLoS One. 2015 Sep 11;10(9):e0136046. doi: 10.1371/journal.pone.0136046. eCollection 2015. PubMed |
AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow.
Saito Y, Chapple RH, Lin A, Kitano A, Nakada D.
Cell Stem Cell. 2015 Sep 29. pii: S1934-5909(15)00374-4. doi: 10.1016/j.stem.2015.08.019.
PubMed
Associated Plasmids |
| CRISPR-CAS9 D10A nickase target-specific fluorescent labeling of double strand DNA for whole genome mapping and structural variation analysis. McCaffrey J, Sibert J, Zhang B, Zhang Y, Hu W, Riethman H, Xiao M. Nucleic Acids Res. 2016 Jan 29;44(2):e11. doi: 10.1093/nar/gkv878. Epub 2015 Oct 19. PubMed |
| CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs. Zhang Y, Yin C, Zhang T, Li F, Yang W, Kaminski R, Fagan PR, Putatunda R, Young WB, Khalili K, Hu W. Sci Rep. 2015 Nov 5;5:16277. doi: 10.1038/srep16277. PubMed |
| Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS. Yin C, Zhang T, Li F, Yang F, Putatunda R, Young WB, Khalili K, Hu W, Zhang Y. AIDS. 2016 May 15;30(8):1163-74. doi: 10.1097/QAD.0000000000001079. PubMed |
| Unlinking an lncRNA from Its Associated cis Element. Paralkar VR, Taborda CC, Huang P, Yao Y, Kossenkov AV, Prasad R, Luan J, Davies JO, Hughes JR, Hardison RC, Blobel GA, Weiss MJ. Mol Cell. 2016 Apr 7;62(1):104-10. doi: 10.1016/j.molcel.2016.02.029. Epub 2016 Mar 31. PubMed |
| A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors. Ruiz S, Mayor-Ruiz C, Lafarga V, Murga M, Vega-Sendino M, Ortega S, Fernandez-Capetillo O. Mol Cell. 2016 Apr 21;62(2):307-313. doi: 10.1016/j.molcel.2016.03.006. Epub 2016 Apr 7. PubMed |
Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Chu VT, Graf R, Wirtz T, Weber T, Favret J, Li X, Petsch K, Tran NT, Sieweke MH, Berek C, Kuhn R, Rajewsky K.
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12514-12519. Epub 2016 Oct 11.
PubMed
Associated Plasmids |
| A Precision Medicine Approach to the Rescue of Function on Malignant Calmodulinopathic Long-QT Syndrome. Limpitikul WB, Dick IE, Tester DJ, Boczek NJ, Limphong P, Yang W, Choi MH, Babich J, DiSilvestre D, Kanter RJ, Tomaselli GF, Ackerman MJ, Yue DT. Circ Res. 2017 Jan 6;120(1):39-48. doi: 10.1161/CIRCRESAHA.116.309283. Epub 2016 Oct 20. PubMed |
| cis-Regulatory Circuits Regulating NEK6 Kinase Overexpression in Transformed B Cells Are Super-Enhancer Independent. Huang Y, Koues OI, Zhao JY, Liu R, Pyfrom SC, Payton JE, Oltz EM. Cell Rep. 2017 Mar 21;18(12):2918-2931. doi: 10.1016/j.celrep.2017.02.067. PubMed |
| Modulation of Human Leukocyte Antigen-C by Human Cytomegalovirus Stimulates KIR2DS1 Recognition by Natural Killer Cells. van der Ploeg K, Chang C, Ivarsson MA, Moffett A, Wills MR, Trowsdale J. Front Immunol. 2017 Mar 29;8:298. doi: 10.3389/fimmu.2017.00298. eCollection 2017. PubMed |
| Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2. Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G, Kingston RE, Modis Y, Lehner PJ. Nat Genet. 2017 Jul;49(7):1035-1044. doi: 10.1038/ng.3878. Epub 2017 Jun 5. PubMed |
| SIRT1 regulates macrophage self-renewal. Imperatore F, Maurizio J, Vargas Aguilar S, Busch CJ, Favret J, Kowenz-Leutz E, Cathou W, Gentek R, Perrin P, Leutz A, Berruyer C, Sieweke MH. EMBO J. 2017 Aug 15;36(16):2353-2372. doi: 10.15252/embj.201695737. Epub 2017 Jul 12. PubMed |
| alpha-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Liu PS, Wang H, Li X, Chao T, Teav T, Christen S, Di Conza G, Cheng WC, Chou CH, Vavakova M, Muret C, Debackere K, Mazzone M, Huang HD, Fendt SM, Ivanisevic J, Ho PC. Nat Immunol. 2017 Sep;18(9):985-994. doi: 10.1038/ni.3796. Epub 2017 Jul 17. PubMed |
| Trap(Seq): An RNA Sequencing-Based Pipeline for the Identification of Gene-Trap Insertions in Mammalian Cells. Mayor-Ruiz C, Dominguez O, Fernandez-Capetillo O. J Mol Biol. 2017 Sep 1;429(18):2780-2789. doi: 10.1016/j.jmb.2017.07.020. Epub 2017 Aug 4. PubMed |
| CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Burr ML, Sparbier CE, Chan YC, Williamson JC, Woods K, Beavis PA, Lam EYN, Henderson MA, Bell CC, Stolzenburg S, Gilan O, Bloor S, Noori T, Morgens DW, Bassik MC, Neeson PJ, Behren A, Darcy PK, Dawson SJ, Voskoboinik I, Trapani JA, Cebon J, Lehner PJ, Dawson MA. Nature. 2017 Sep 7;549(7670):101-105. doi: 10.1038/nature23643. Epub 2017 Aug 16. PubMed |
| ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis. Trumbach D, Pfeiffer S, Poppe M, Scherb H, Doll S, Wurst W, Schick JA. BMC Genomics. 2017 Nov 25;18(1):905. doi: 10.1186/s12864-017-4285-2. PubMed |
| Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11. Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, Martin A, Di Lorenzo F, Py BF, Molinaro A, Henry T. Nat Commun. 2018 Jan 16;9(1):242. doi: 10.1038/s41467-017-02682-y. PubMed |
Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling.
Oldrini B, Curiel-Garcia A, Marques C, Matia V, Uluckan O, Grana-Castro O, Torres-Ruiz R, Rodriguez-Perales S, Huse JT, Squatrito M.
Nat Commun. 2018 Apr 13;9(1):1466. doi: 10.1038/s41467-018-03731-w.
PubMed
Associated Plasmids |
| CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation. Garcia-Carpizo V, Ruiz-Llorente S, Sarmentero J, Grana-Castro O, Pisano DG, Barrero MJ. Epigenetics Chromatin. 2018 Jun 8;11(1):30. doi: 10.1186/s13072-018-0197-x. PubMed |
| Endogenous HIF2A reporter systems for high-throughput functional screening. Zaini MN, Patel SA, Syafruddin SE, Rodrigues P, Vanharanta S. Sci Rep. 2018 Aug 13;8(1):12063. doi: 10.1038/s41598-018-30499-2. PubMed |
| High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms. Nightingale K, Lin KM, Ravenhill BJ, Davies C, Nobre L, Fielding CA, Ruckova E, Fletcher-Etherington A, Soday L, Nichols H, Sugrue D, Wang ECY, Moreno P, Umrania Y, Huttlin EL, Antrobus R, Davison AJ, Wilkinson GWG, Stanton RJ, Tomasec P, Weekes MP. Cell Host Microbe. 2018 Sep 12;24(3):447-460.e11. doi: 10.1016/j.chom.2018.07.011. Epub 2018 Aug 16. PubMed |
| AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A. Davies AK, Itzhak DN, Edgar JR, Archuleta TL, Hirst J, Jackson LP, Robinson MS, Borner GHH. Nat Commun. 2018 Sep 27;9(1):3958. doi: 10.1038/s41467-018-06172-7. PubMed |
| The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1. Menzies SA, Volkmar N, van den Boomen DJ, Timms RT, Dickson AS, Nathan JA, Lehner PJ. Elife. 2018 Dec 13;7. pii: 40009. doi: 10.7554/eLife.40009. PubMed |
| CREBBP/EP300 Bromodomain Inhibition Affects the Proliferation of AR-Positive Breast Cancer Cell Lines. Garcia-Carpizo V, Ruiz-Llorente S, Sarmentero J, Gonzalez-Corpas A, Barrero MJ. Mol Cancer Res. 2019 Mar;17(3):720-730. doi: 10.1158/1541-7786.MCR-18-0719. Epub 2019 Jan 3. PubMed |
| SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. Zhu C, Li B, Frontzek K, Liu Y, Aguzzi A. J Exp Med. 2019 Apr 1;216(4):743-756. doi: 10.1084/jem.20171885. Epub 2019 Mar 6. PubMed |
| A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma. Syafruddin SE, Rodrigues P, Vojtasova E, Patel SA, Zaini MN, Burge J, Warren AY, Stewart GD, Eisen T, Bihary D, Samarajiwa SA, Vanharanta S. Nat Commun. 2019 Mar 11;10(1):1152. doi: 10.1038/s41467-019-09116-x. PubMed |
CRISPR-KO screen identifies Dmap1 as a regulator of chemically-induced reprogramming and differentiation of cardiac progenitors.
Yu JSL, Palano G, Lim C, Moggio A, Drowley L, Plowright AT, Bohlooly-Y M, Rosen BS, Hansson EM, Wang QD, Yusa K.
Stem Cells. 2019 Apr 1. doi: 10.1002/stem.3012.
PubMed
Associated Plasmids |
| Intracellular Ca(2+) Homeostasis and Nuclear Export Mediate Exit from Naive Pluripotency. MacDougall MS, Clarke R, Merrill BJ. Cell Stem Cell. 2019 Aug 1;25(2):210-224.e6. doi: 10.1016/j.stem.2019.04.015. Epub 2019 May 16. PubMed |
| Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development. Bai M, Han Y, Wu Y, Liao J, Li L, Wang L, Li Q, Xing W, Chen L, Zou W, Li J. PLoS Biol. 2019 Jul 2;17(7):e3000350. doi: 10.1371/journal.pbio.3000350. eCollection 2019 Jul. PubMed |
| Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice. Dash PK, Kaminski R, Bella R, Su H, Mathews S, Ahooyi TM, Chen C, Mancuso P, Sariyer R, Ferrante P, Donadoni M, Robinson JA, Sillman B, Lin Z, Hilaire JR, Banoub M, Elango M, Gautam N, Mosley RL, Poluektova LY, McMillan J, Bade AN, Gorantla S, Sariyer IK, Burdo TH, Young WB, Amini S, Gordon J, Jacobson JM, Edagwa B, Khalili K, Gendelman HE. Nat Commun. 2019 Jul 2;10(1):2753. doi: 10.1038/s41467-019-10366-y. PubMed |
| A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells. Olbrich T, Vega-Sendino M, Murga M, de Carcer G, Malumbres M, Ortega S, Ruiz S, Fernandez-Capetillo O. Cell Rep. 2019 Jul 16;28(3):597-604.e4. doi: 10.1016/j.celrep.2019.06.060. PubMed |
| An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer. Burr ML, Sparbier CE, Chan KL, Chan YC, Kersbergen A, Lam EYN, Azidis-Yates E, Vassiliadis D, Bell CC, Gilan O, Jackson S, Tan L, Wong SQ, Hollizeck S, Michalak EM, Siddle HV, McCabe MT, Prinjha RK, Guerra GR, Solomon BJ, Sandhu S, Dawson SJ, Beavis PA, Tothill RW, Cullinane C, Lehner PJ, Sutherland KD, Dawson MA. Cancer Cell. 2019 Oct 14;36(4):385-401.e8. doi: 10.1016/j.ccell.2019.08.008. Epub 2019 Sep 26. PubMed |
Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients.
Magnotti F, Lefeuvre L, Benezech S, Malsot T, Waeckel L, Martin A, Kerever S, Chirita D, Desjonqueres M, Duquesne A, Gerfaud-Valentin M, Laurent A, Seve P, Popoff MR, Walzer T, Belot A, Jamilloux Y, Henry T.
EMBO Mol Med. 2019 Oct 7:e10547. doi: 10.15252/emmm.201910547.
PubMed
Associated Plasmids |
| Regional Gene Repression by DNA Double-Strand Breaks in G1 Phase Cells. Purman CE, Collins PL, Porter SI, Saini A, Gupta H, Sleckman BP, Oltz EM. Mol Cell Biol. 2019 Nov 25;39(24). pii: MCB.00181-19. doi: 10.1128/MCB.00181-19. Print 2019 Dec 15. PubMed |
| Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability. Rom A, Melamed L, Gil N, Goldrich MJ, Kadir R, Golan M, Biton I, Perry RB, Ulitsky I. Nat Commun. 2019 Nov 8;10(1):5092. doi: 10.1038/s41467-019-13075-8. PubMed |
| The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells. Harding HP, Ordonez A, Allen F, Parts L, Inglis AJ, Williams RL, Ron D. Elife. 2019 Nov 21;8. pii: 50149. doi: 10.7554/eLife.50149. PubMed |
| Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-gamma-signaling mutant cancer cells. Williams JB, Li S, Higgs EF, Cabanov A, Wang X, Huang H, Gajewski TF. Nat Commun. 2020 Jan 30;11(1):602. doi: 10.1038/s41467-020-14290-4. PubMed |
| Reversible promoter methylation determines fluctuating expression of acute phase proteins. Zhang SC, Wang MY, Feng JR, Chang Y, Ji SR, Wu Y. Elife. 2020 Mar 30;9. pii: 51317. doi: 10.7554/eLife.51317. PubMed |
| Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms. Wandel MP, Kim BH, Park ES, Boyle KB, Nayak K, Lagrange B, Herod A, Henry T, Zilbauer M, Rohde J, MacMicking JD, Randow F. Nat Immunol. 2020 Aug;21(8):880-891. doi: 10.1038/s41590-020-0697-2. Epub 2020 Jun 15. PubMed |
| Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia. Deniz O, Ahmed M, Todd CD, Rio-Machin A, Dawson MA, Branco MR. Nat Commun. 2020 Jul 14;11(1):3506. doi: 10.1038/s41467-020-17206-4. PubMed |
| Histone methyltransferase activity programs nuclear peripheral genome positioning. See K, Kiseleva AA, Smith CL, Liu F, Li J, Poleshko A, Epstein JA. Dev Biol. 2020 Oct 1;466(1-2):90-98. doi: 10.1016/j.ydbio.2020.07.010. Epub 2020 Jul 24. PubMed |
| MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas. Oldrini B, Vaquero-Siguero N, Mu Q, Kroon P, Zhang Y, Galan-Ganga M, Bao Z, Wang Z, Liu H, Sa JK, Zhao J, Kim H, Rodriguez-Perales S, Nam DH, Verhaak RGW, Rabadan R, Jiang T, Wang J, Squatrito M. Nat Commun. 2020 Aug 4;11(1):3883. doi: 10.1038/s41467-020-17717-0. PubMed |
| Protective anti-prion antibodies in human immunoglobulin repertoires. Senatore A, Frontzek K, Emmenegger M, Chincisan A, Losa M, Reimann R, Horny G, Guo J, Fels S, Sorce S, Zhu C, George N, Ewert S, Pietzonka T, Hornemann S, Aguzzi A. EMBO Mol Med. 2020 Sep 7;12(9):e12739. doi: 10.15252/emmm.202012739. Epub 2020 Aug 10. PubMed |
| Regulation of neuronal commitment in mouse embryonic stem cells by the Reno1/Bahcc1 locus. Hezroni H, Ben-Tov Perry R, Gil N, Degani N, Ulitsky I. EMBO Rep. 2020 Nov 5;21(11):e51264. doi: 10.15252/embr.202051264. Epub 2020 Sep 24. PubMed |
| Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation. Gabaev I, Williamson JC, Crozier TWM, Schulz TF, Lehner PJ. Cell Rep. 2020 Oct 13;33(2):108249. doi: 10.1016/j.celrep.2020.108249. PubMed |
| Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC. Lankes K, Hassan Z, Doffo MJ, Schneeweis C, Lier S, Ollinger R, Rad R, Kramer OH, Keller U, Saur D, Reichert M, Schneider G, Wirth M. Mol Oncol. 2020 Dec;14(12):3048-3064. doi: 10.1002/1878-0261.12835. Epub 2020 Nov 8. PubMed |
| De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment. Rodger C, Flex E, Allison RJ, Sanchis-Juan A, Hasenahuer MA, Cecchetti S, French CE, Edgar JR, Carpentieri G, Ciolfi A, Pantaleoni F, Bruselles A, Onesimo R, Zampino G, Marcon F, Siniscalchi E, Lees M, Krishnakumar D, McCann E, Yosifova D, Jarvis J, Kruer MC, Marks W, Campbell J, Allen LE, Gustincich S, Raymond FL, Tartaglia M, Reid E. Am J Hum Genet. 2020 Dec 3;107(6):1129-1148. doi: 10.1016/j.ajhg.2020.10.012. Epub 2020 Nov 12. PubMed |
| SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression. Hou G, Harley ITW, Lu X, Zhou T, Xu N, Yao C, Qin Y, Ouyang Y, Ma J, Zhu X, Yu X, Xu H, Dai D, Ding H, Yin Z, Ye Z, Deng J, Zhou M, Tang Y, Namjou B, Guo Y, Weirauch MT, Kottyan LC, Harley JB, Shen N. Nat Commun. 2021 Jan 8;12(1):135. doi: 10.1038/s41467-020-20460-1. PubMed |
| No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor. Shilts J, Crozier TWM, Greenwood EJD, Lehner PJ, Wright GJ. Sci Rep. 2021 Jan 11;11(1):413. doi: 10.1038/s41598-020-80464-1. PubMed |
| The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr. Dupont L, Bloor S, Williamson JC, Cuesta SM, Shah R, Teixeira-Silva A, Naamati A, Greenwood EJD, Sarafianos SG, Matheson NJ, Lehner PJ. Cell Host Microbe. 2021 May 12;29(5):792-805.e6. doi: 10.1016/j.chom.2021.03.001. Epub 2021 Apr 2. PubMed |
| Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella JF, Thomas P, Sauvageau G, Adams DJ, Wong CC. Nat Commun. 2021 Apr 30;12(1):2482. doi: 10.1038/s41467-021-22750-8. PubMed |
| Widespread displacement of DNA- and RNA-binding factors underlies toxicity of arginine-rich cell-penetrating peptides. Lafarga V, Sirozh O, Diaz-Lopez I, Galarreta A, Hisaoka M, Zarzuela E, Boskovic J, Jovanovic B, Fernandez-Leiro R, Munoz J, Stoecklin G, Ventoso I, Fernandez-Capetillo O. EMBO J. 2021 Jul 1;40(13):e103311. doi: 10.15252/embj.2019103311. Epub 2021 May 12. PubMed |
| Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination. Chen CC, Chen BR, Wang Y, Curman P, Beilinson HA, Brecht RM, Liu CC, Farrell RJ, de Juan-Sanz J, Charbonnier LM, Kajimura S, Ryan TA, Schatz DG, Chatila TA, Wikstrom JD, Tyler JK, Sleckman BP. J Exp Med. 2021 Aug 2;218(8). pii: 212182. doi: 10.1084/jem.20201708. Epub 2021 May 25. PubMed |
| Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element. Baxter JS, Johnson N, Tomczyk K, Gillespie A, Maguire S, Brough R, Fachal L, Michailidou K, Bolla MK, Wang Q, Dennis J, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Augustinsson A, Becher H, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bogdanova NV, Bojesen SE, Brenner H, Brucker SY, Cai Q, Campa D, Canzian F, Castelao JE, Chan TL, Chang-Claude J, Chanock SJ, Chenevix-Trench G, Choi JY, Clarke CL, Colonna S, Conroy DM, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Dork T, Dossus L, Dwek M, Eccles DM, Ekici AB, Eliassen AH, Engel C, Fasching PA, Figueroa J, Flyger H, Gago-Dominguez M, Gao C, Garcia-Closas M, Garcia-Saenz JA, Ghoussaini M, Giles GG, Goldberg MS, Gonzalez-Neira A, Guenel P, Gundert M, Haeberle L, Hahnen E, Haiman CA, Hall P, Hamann U, Hartman M, Hatse S, Hauke J, Hollestelle A, Hoppe R, Hopper JL, Hou MF, Ito H, Iwasaki M, Jager A, Jakubowska A, Janni W, John EM, Joseph V, Jung A, Kaaks R, Kang D, Keeman R, Khusnutdinova E, Kim SW, Kosma VM, Kraft P, Kristensen VN, Kubelka-Sabit K, Kurian AW, Kwong A, Lacey JV, Lambrechts D, Larson NL, Larsson SC, Le Marchand L, Lejbkowicz F, Li J, Long J, Lophatananon A, Lubinski J, Mannermaa A, Manoochehri M, Manoukian S, Margolin S, Matsuo K, Mavroudis D, Mayes R, Menon U, Milne RL, Mohd Taib NA, Muir K, Muranen TA, Murphy RA, Nevanlinna H, O'Brien KM, Offit K, Olson JE, Olsson H, Park SK, Park-Simon TW, Patel AV, Peterlongo P, Peto J, Plaseska-Karanfilska D, Presneau N, Pylkas K, Rack B, Rennert G, Romero A, Ruebner M, Rudiger T, Saloustros E, Sandler DP, Sawyer EJ, Schmidt MK, Schmutzler RK, Schneeweiss A, Schoemaker MJ, Shah M, Shen CY, Shu XO, Simard J, Southey MC, Stone J, Surowy H, Swerdlow AJ, Tamimi RM, Tapper WJ, Taylor JA, Teo SH, Teras LR, Terry MB, Toland AE, Tomlinson I, Truong T, Tseng CC, Untch M, Vachon CM, van den Ouweland AMW, Wang SS, Weinberg CR, Wendt C, Winham SJ, Winqvist R, Wolk A, Wu AH, Yamaji T, Zheng W, Ziogas A, Pharoah PDP, Dunning AM, Easton DF, Pettitt SJ, Lord CJ, Haider S, Orr N, Fletcher O. Am J Hum Genet. 2021 Jul 1;108(7):1190-1203. doi: 10.1016/j.ajhg.2021.05.013. Epub 2021 Jun 18. PubMed |
| Highly conserved and cis-acting lncRNAs produced from paralogous regions in the center of HOXA and HOXB clusters in the endoderm lineage. Degani N, Lubelsky Y, Perry RB, Ainbinder E, Ulitsky I. PLoS Genet. 2021 Jul 19;17(7):e1009681. doi: 10.1371/journal.pgen.1009681. eCollection 2021 Jul. PubMed |
| NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1. Marques C, Unterkircher T, Kroon P, Oldrini B, Izzo A, Dramaretska Y, Ferrarese R, Kling E, Schnell O, Nelander S, Wagner EF, Bakiri L, Gargiulo G, Carro MS, Squatrito M. Elife. 2021 Aug 17;10. pii: 64846. doi: 10.7554/eLife.64846. PubMed |
| The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining. Chen BR, Wang Y, Shen ZJ, Bennett A, Hindi I, Tyler JK, Sleckman BP. DNA Repair (Amst). 2021 Dec;108:103217. doi: 10.1016/j.dnarep.2021.103217. Epub 2021 Sep 1. PubMed |
| Mapping the evolving landscape of super-enhancers during cell differentiation. Kai Y, Li BE, Zhu M, Li GY, Chen F, Han Y, Cha HJ, Orkin SH, Cai W, Huang J, Yuan GC. Genome Biol. 2021 Sep 15;22(1):269. doi: 10.1186/s13059-021-02485-x. PubMed |
| Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists. Grinkevitch V, Wappett M, Crawford N, Price S, Lees A, McCann C, McAllister K, Prehn J, Young J, Bateson J, Gallagher L, Michaut M, Iyer V, Chatzipli A, Barthorpe S, Ciznadija D, Sloma I, Wesa A, Tice DA, Wessels L, Garnett M, Longley DB, McDermott U, McDade SS. Mol Cancer Ther. 2022 Apr 1;21(4):594-606. doi: 10.1158/1535-7163.MCT-21-0532. PubMed |
| Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery. Zhou T, Zhu X, Ye Z, Wang YF, Yao C, Xu N, Zhou M, Ma J, Qin Y, Shen Y, Tang Y, Yin Z, Xu H, Zhang Y, Zang X, Ding H, Yang W, Guo Y, Harley JB, Namjou B, Kaufman KM, Kottyan LC, Weirauch MT, Hou G, Shen N. Nat Commun. 2022 Apr 6;13(1):1855. doi: 10.1038/s41467-022-29514-y. PubMed |
| DNA-PK promotes DNA end resection at DNA double strand breaks in G(0) cells. Fowler FC, Chen BR, Zolnerowich N, Wu W, Pavani R, Paiano J, Peart C, Chen Z, Nussenzweig A, Sleckman BP, Tyler JK. Elife. 2022 May 16;11:e74700. doi: 10.7554/eLife.74700. PubMed |
| Identification of a distal enhancer that determines the expression pattern of acute phase marker C-reactive protein. Wang MY, Zhang CM, Zhou HH, Ge ZB, Su CC, Lou ZH, Zhang XY, Xu TT, Li SY, Zhu L, Zhou YL, Wu Y, Ji SR. J Biol Chem. 2022 Aug;298(8):102160. doi: 10.1016/j.jbc.2022.102160. Epub 2022 Jun 17. PubMed |
Sequestration of LINE-1 in cytosolic aggregates by MOV10 restricts retrotransposition.
Arora R, Bodak M, Penouty L, Hackman C, Ciaudo C.
EMBO Rep. 2022 Jul 20:e54458. doi: 10.15252/embr.202154458.
PubMed
Associated Plasmids |
| A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourao ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M. Nature. 2022 Aug;608(7924):778-783. doi: 10.1038/s41586-022-05022-3. Epub 2022 Aug 3. PubMed |
| Evidence against the Human Metapneumovirus G, SH, and M2-2 Proteins as Bona Fide Interferon Antagonists. Groen K, van Nieuwkoop S, Lamers MM, Fouchier RAM, van den Hoogen BG. J Virol. 2022 Sep 14;96(17):e0072322. doi: 10.1128/jvi.00723-22. Epub 2022 Aug 17. PubMed |
| AP-4 regulates neuronal lysosome composition, function, and transport via regulating export of critical lysosome receptor proteins at the trans-Golgi network. Majumder P, Edmison D, Rodger C, Patel S, Reid E, Gowrishankar S. Mol Biol Cell. 2022 Oct 1;33(12):ar102. doi: 10.1091/mbc.E21-09-0473. Epub 2022 Aug 17. PubMed |
| Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus. Hou G, Zhou T, Xu N, Yin Z, Zhu X, Zhang Y, Cui Y, Ma J, Tang Y, Cheng Z, Shen Y, Chen Y, Zou LH, Wang YF, Yin Z, Guo Y, Ding H, Ye Z, Shen N. Arthritis Rheumatol. 2023 Apr;75(4):574-585. doi: 10.1002/art.42390. Epub 2023 Feb 8. PubMed |
| ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma. Ferrarese R, Izzo A, Andrieux G, Lagies S, Bartmuss JP, Masilamani AP, Wasilenko A, Osti D, Faletti S, Schulzki R, Yuan S, Kling E, Ribecco V, Heiland DH, Tholen S, Prinz M, Pelicci G, Kammerer B, Boerries M, Carro MS. Life Sci Alliance. 2022 Nov 22;6(1):e202201400. doi: 10.26508/lsa.202201400. Print 2023 Jan. PubMed |
| The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer. An HW, Seok SH, Kwon JW, Choudhury AD, Oh JS, Voon DC, Kim DY, Park JW. Cell Rep. 2022 Dec 27;41(13):111878. doi: 10.1016/j.celrep.2022.111878. PubMed |
| Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes. Sparbier CE, Gillespie A, Gomez J, Kumari N, Motazedian A, Chan KL, Bell CC, Gilan O, Chan YC, Popp S, Gough DJ, Eckersley-Maslin MA, Dawson SJ, Lehner PJ, Sutherland KD, Ernst P, McGeehan GM, Lam EYN, Burr ML, Dawson MA. Nat Cell Biol. 2023 Feb;25(2):258-272. doi: 10.1038/s41556-022-01056-x. Epub 2023 Jan 12. PubMed |
| The exocyst complex is an essential component of the mammalian constitutive secretory pathway. Pereira C, Stalder D, Anderson GSF, Shun-Shion AS, Houghton J, Antrobus R, Chapman MA, Fazakerley DJ, Gershlick DC. J Cell Biol. 2023 May 1;222(5):e202205137. doi: 10.1083/jcb.202205137. Epub 2023 Mar 15. PubMed |
| Cancer Cell-Derived PDGFB Stimulates mTORC1 Activation in Renal Carcinoma. Abuhamad AY, Mohamad Zamberi NN, Vanharanta S, Mohd Yusuf SNH, Mohtar MA, Syafruddin SE. Int J Mol Sci. 2023 Mar 29;24(7):6447. doi: 10.3390/ijms24076447. PubMed |
| CRISPR editing of CCR5 and HIV-1 facilitates viral elimination in antiretroviral drug-suppressed virus-infected humanized mice. Dash PK, Chen C, Kaminski R, Su H, Mancuso P, Sillman B, Zhang C, Liao S, Sravanam S, Liu H, Waight E, Guo L, Mathews S, Sariyer R, Mosley RL, Poluektova LY, Caocci M, Amini S, Gorantla S, Burdo TH, Edagwa B, Gendelman HE, Khalili K. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2217887120. doi: 10.1073/pnas.2217887120. Epub 2023 May 1. PubMed |
| Complex regulation of Eomes levels mediated through distinct functional features of the Meteor long non-coding RNA locus. Gil N, Perry RB, Mukamel Z, Tuck A, Buhler M, Ulitsky I. Cell Rep. 2023 May 30;42(6):112569. doi: 10.1016/j.celrep.2023.112569. PubMed |
| Proteomics of immune cells from liver tumors reveals immunotherapy targets. Canale FP, Neumann J, von Renesse J, Loggi E, Pecoraro M, Vogel I, Zoppi G, Antonini G, Wolf T, Jin W, Zheng X, La Barba G, Birgin E, Forkel M, Nilsson T, Marone R, Mueller H, Pelletier N, Jeker LT, Civenni G, Schlapbach C, Catapano CV, Seifert L, Seifert AM, Gillessen S, De Dosso S, Cristaudi A, Rahbari NN, Ercolani G, Geiger R. Cell Genom. 2023 May 30;3(6):100331. doi: 10.1016/j.xgen.2023.100331. eCollection 2023 Jun 14. PubMed |
| TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. Shibata T, Sato R, Taoka M, Saitoh SI, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, Tojo A, Ohtsuki M, Ohto U, Shimizu T, Ozawa M, Yoshida N, Isobe T, Latz E, Mukai K, Taguchi T, Hemmi H, Akira S, Miyake K. J Exp Med. 2023 Sep 4;220(9):e20230054. doi: 10.1084/jem.20230054. Epub 2023 Jul 18. PubMed |
| MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies. Champion A, Rowland A, Yee L, van den Boomen D, Reeves M, Lehner P, Sinclair J, Poole E. J Med Virol. 2023 Nov;95(11):e29227. doi: 10.1002/jmv.29227. PubMed |
| Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer. Pfeifer M, Brammeld JS, Price S, Pilling J, Bhavsar D, Farcas A, Bateson J, Sundarrajan A, Miragaia RJ, Guan N, Arnold S, Tariq L, Grondine M, Talbot S, Guerriero ML, O'Neill DJ, Young J, Company C, Dunn S, Thorpe H, Martin MJ, Maratea K, Barrell D, Ahdesmaki M, Mettetal JT, Brownell J, McDermott U. Commun Biol. 2024 Apr 24;7(1):497. doi: 10.1038/s42003-024-06190-w. PubMed |
| Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers. Diepstraten ST, Yuan Y, La Marca JE, Young S, Chang C, Whelan L, Ross AM, Fischer KC, Pomilio G, Morris R, Georgiou A, Litalien V, Brown FC, Roberts AW, Strasser A, Wei AH, Kelly GL. Cancer Cell. 2024 May 13;42(5):850-868.e9. doi: 10.1016/j.ccell.2024.04.004. Epub 2024 Apr 25. PubMed |
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