pST1374-NLS-flag-linker-Cas9 Citations (131)
Originally described in: Generation of gene-modified mice via Cas9/RNA-mediated gene targeting.Shen B, Zhang J, Wu H, Wang J, Ma K, Li Z, Zhang X, Zhang P, Huang X Cell Res. 2013 Apr 2. doi: 10.1038/cr.2013.46. PubMed Journal
Articles Citing pST1374-NLS-flag-linker-Cas9
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| Pseudovirus-based neuraminidase inhibition assays reveal potential H5N1 drug-resistant mutations. Lu Y, Jiang T. Protein Cell. 2013 May;4(5):356-63. doi: 10.1007/s13238-013-2125-y. Epub 2013 Apr 15. PubMed |
| Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Niu Y, Shen B, Cui Y, Chen Y, Wang J, Wang L, Kang Y, Zhao X, Si W, Li W, Xiang AP, Zhou J, Guo X, Bi Y, Si C, Hu B, Dong G, Wang H, Zhou Z, Li T, Tan T, Pu X, Wang F, Ji S, Zhou Q, Huang X, Ji W, Sha J. Cell. 2014 Feb 13;156(4):836-43. doi: 10.1016/j.cell.2014.01.027. Epub 2014 Jan 30. PubMed |
| Dual sgRNAs facilitate CRISPR/Cas9-mediated mouse genome targeting. Zhou J, Wang J, Shen B, Chen L, Su Y, Yang J, Zhang W, Tian X, Huang X. FEBS J. 2014 Apr;281(7):1717-25. doi: 10.1111/febs.12735. Epub 2014 Feb 26. PubMed |
Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects.
Shen B, Zhang W, Zhang J, Zhou J, Wang J, Chen L, Wang L, Hodgkins A, Iyer V, Huang X, Skarnes WC.
Nat Methods. 2014 Mar 2. doi: 10.1038/nmeth.2857.
PubMed
Associated Plasmids |
| Heritable multiplex genetic engineering in rats using CRISPR/Cas9. Ma Y, Shen B, Zhang X, Lu Y, Chen W, Ma J, Huang X, Zhang L. PLoS One. 2014 Mar 5;9(3):e89413. doi: 10.1371/journal.pone.0089413. eCollection 2014. PubMed |
| Generation of eGFP and Cre knockin rats by CRISPR/Cas9. Ma Y, Ma J, Zhang X, Chen W, Yu L, Lu Y, Bai L, Shen B, Huang X, Zhang L. FEBS J. 2014 Sep;281(17):3779-90. doi: 10.1111/febs.12935. Epub 2014 Aug 13. PubMed |
| Efficient in vivo deletion of a large imprinted lncRNA by CRISPR/Cas9. Han J, Zhang J, Chen L, Shen B, Zhou J, Hu B, Du Y, Tate PH, Huang X, Zhang W. RNA Biol. 2014;11(7):829-35. doi: 10.4161/rna.29624. Epub 2014 Aug 19. PubMed |
| An efficient genotyping method for genome-modified animals and human cells generated with CRISPR/Cas9 system. Zhu X, Xu Y, Yu S, Lu L, Ding M, Cheng J, Song G, Gao X, Yao L, Fan D, Meng S, Zhang X, Hu S, Tian Y. Sci Rep. 2014 Sep 19;4:6420. doi: 10.1038/srep06420. PubMed |
| Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA. Wang Y, Du Y, Shen B, Zhou X, Li J, Liu Y, Wang J, Zhou J, Hu B, Kang N, Gao J, Yu L, Huang X, Wei H. Sci Rep. 2015 Feb 5;5:8256. doi: 10.1038/srep08256. PubMed |
| The genetics of human infertility by functional interrogation of SNPs in mice. Singh P, Schimenti JC. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10431-6. doi: 10.1073/pnas.1506974112. Epub 2015 Aug 3. PubMed |
| Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system. Wang X, Yu H, Lei A, Zhou J, Zeng W, Zhu H, Dong Z, Niu Y, Shi B, Cai B, Liu J, Huang S, Yan H, Zhao X, Zhou G, He X, Chen X, Yang Y, Jiang Y, Shi L, Tian X, Wang Y, Ma B, Huang X, Qu L, Chen Y. Sci Rep. 2015 Sep 10;5:13878. doi: 10.1038/srep13878. PubMed |
| Efficient Generation of Gene-Modified Pigs Harboring Precise Orthologous Human Mutation via CRISPR/Cas9-Induced Homology-Directed Repair in Zygotes. Zhou X, Wang L, Du Y, Xie F, Li L, Liu Y, Liu C, Wang S, Zhang S, Huang X, Wang Y, Wei H. Hum Mutat. 2016 Jan;37(1):110-8. doi: 10.1002/humu.22913. Epub 2015 Oct 23. PubMed |
| Preliminary Characterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9 System. Bao D, Ma Y, Zhang X, Guan F, Chen W, Gao K, Qin C, Zhang L. Sci Rep. 2015 Nov 5;5:15942. doi: 10.1038/srep15942. PubMed |
| Regulator of G-Protein Signaling 10 Negatively Regulates Cardiac Remodeling by Blocking Mitogen-Activated Protein Kinase-Extracellular Signal-Regulated Protein Kinase 1/2 Signaling. Miao R, Lu Y, Xing X, Li Y, Huang Z, Zhong H, Huang Y, Chen AF, Tang X, Li H, Cai J, Yuan H. Hypertension. 2016 Jan;67(1):86-98. doi: 10.1161/HYPERTENSIONAHA.115.05957. Epub 2015 Nov 16. PubMed |
| GPI Anchor Modification Machinery Deficiency is Responsible for the Formation of Pro-PrP in BxPC-3 and Increases Cancer Cell Motility. Yang L, Gao Z, Hu L, Wu G, Yang X, Zhang L, Zhu Y, Wong BS, Xin W, Sy MS, Li C. J Biol Chem. 2015 Dec 18. pii: jbc.M115.705830. PubMed |
| CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients. Su S, Hu B, Shao J, Shen B, Du J, Du Y, Zhou J, Yu L, Zhang L, Chen F, Sha H, Cheng L, Meng F, Zou Z, Huang X, Liu B. Sci Rep. 2016 Jan 28;6:20070. doi: 10.1038/srep20070. PubMed |
| Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway. Li CY, Zhou Q, Yang LC, Chen YH, Hou JW, Guo K, Wang YP, Li YG. Basic Res Cardiol. 2016 Mar;111(2):19. doi: 10.1007/s00395-016-0536-7. Epub 2016 Feb 18. PubMed |
| Hepatic Oncostatin M Receptor beta Regulates Obesity-Induced Steatosis and Insulin Resistance. Luo P, Wang PX, Li ZZ, Zhang XJ, Jiang X, Gong J, Qin JJ, Guo J, Zhu X, Yang S, Li H. Am J Pathol. 2016 May;186(5):1278-92. doi: 10.1016/j.ajpath.2015.12.028. Epub 2016 Mar 11. PubMed |
| Ubiquitin-Specific Protease 4 Is an Endogenous Negative Regulator of Pathological Cardiac Hypertrophy. He B, Zhao YC, Gao LC, Ying XY, Xu LW, Su YY, Ji QQ, Lin N, Pu J. Hypertension. 2016 Jun;67(6):1237-48. doi: 10.1161/HYPERTENSIONAHA.116.07392. Epub 2016 Apr 4. PubMed |
| BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes. Yu C, Ji SY, Sha QQ, Dang Y, Zhou JJ, Zhang YL, Liu Y, Wang ZW, Hu B, Sun QY, Sun SC, Tang F, Fan HY. Nat Struct Mol Biol. 2016 May;23(5):387-94. doi: 10.1038/nsmb.3204. Epub 2016 Apr 11. PubMed |
| Pivotal Role of Regulator of G-protein Signaling 12 in Pathological Cardiac Hypertrophy. Huang J, Chen L, Yao Y, Tang C, Ding J, Fu C, Li H, Ma G. Hypertension. 2016 Jun;67(6):1228-36. doi: 10.1161/HYPERTENSIONAHA.115.06877. Epub 2016 Apr 18. PubMed |
| Generation of an Oocyte-Specific Cas9 Transgenic Mouse for Genome Editing. Zhang L, Zhou J, Han J, Hu B, Hou N, Shi Y, Huang X, Lou X. PLoS One. 2016 Apr 27;11(4):e0154364. doi: 10.1371/journal.pone.0154364. eCollection 2016. PubMed |
| Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve. Dong Z, Huang M, Liu Z, Xie P, Dong Y, Wu X, Qu Z, Shen B, Huang X, Zhang T, Li J, Liu J, Yanase T, Zhou C, Xu Y. Cell Death Differ. 2016 May 20. doi: 10.1038/cdd.2016.47. PubMed |
| Regulator of G protein signalling 14 attenuates cardiac remodelling through the MEK-ERK1/2 signalling pathway. Li Y, Tang XH, Li XH, Dai HJ, Miao RJ, Cai JJ, Huang ZJ, Chen AF, Xing XW, Lu Y, Yuan H. Basic Res Cardiol. 2016 Jul;111(4):47. doi: 10.1007/s00395-016-0566-1. Epub 2016 Jun 13. PubMed |
| Generation and analysis of zebrafish melanoma models. Wojciechowska S, van Rooijen E, Ceol C, Patton EE, White RM. Methods Cell Biol. 2016;134:531-49. doi: 10.1016/bs.mcb.2016.03.008. Epub 2016 Apr 18. PubMed |
| CRISPR-Cas9 mediated genetic engineering for the purification of the endogenous integrator complex from mammalian cells. Baillat D, Russell WK, Wagner EJ. Protein Expr Purif. 2016 Dec;128:101-8. doi: 10.1016/j.pep.2016.08.011. Epub 2016 Aug 19. PubMed |
| Multiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep. Wang X, Niu Y, Zhou J, Yu H, Kou Q, Lei A, Zhao X, Yan H, Cai B, Shen Q, Zhou S, Zhu H, Zhou G, Niu W, Hua J, Jiang Y, Huang X, Ma B, Chen Y. Sci Rep. 2016 Aug 26;6:32271. doi: 10.1038/srep32271. PubMed |
| Efficient edition of the bovine PRNP prion gene in somatic cells and IVF embryos using the CRISPR/Cas9 system. Bevacqua RJ, Fernandez-Martin R, Savy V, Canel NG, Gismondi MI, Kues WA, Carlson DF, Fahrenkrug SC, Niemann H, Taboga OA, Ferraris S, Salamone DF. Theriogenology. 2016 Nov;86(8):1886-1896.e1. doi: 10.1016/j.theriogenology.2016.06.010. Epub 2016 Jun 15. PubMed |
| Novel Protective Role for Ubiquitin-Specific Protease 18 in Pathological Cardiac Remodeling. Ying X, Zhao Y, Yao T, Yuan A, Xu L, Gao L, Ding S, Ding H, Pu J, He B. Hypertension. 2016 Nov;68(5):1160-1170. doi: 10.1161/HYPERTENSIONAHA.116.07562. Epub 2016 Aug 29. PubMed |
| Generation of VDR Knock-Out Mice via Zygote Injection of CRISPR/Cas9 System. Zhang T, Yin Y, Liu H, Du W, Ren C, Wang L, Lu H, Zhang Z. PLoS One. 2016 Sep 29;11(9):e0163551. doi: 10.1371/journal.pone.0163551. eCollection 2016. PubMed |
| Dual specific phosphatase 12 ameliorates cardiac hypertrophy in response to pressure overload. Li WM, Zhao YF, Zhu GF, Peng WH, Zhu MY, Yu XJ, Chen W, Xu DC, Xu YW. Clin Sci (Lond). 2017 Jan 1;131(2):141-154. doi: 10.1042/CS20160664. Epub 2016 Oct 4. PubMed |
| C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility. Gomez-H L, Felipe-Medina N, Sanchez-Martin M, Davies OR, Ramos I, Garcia-Tunon I, de Rooij DG, Dereli I, Toth A, Barbero JL, Benavente R, Llano E, Pendas AM. Nat Commun. 2016 Oct 31;7:13298. doi: 10.1038/ncomms13298. PubMed |
| In Vitro and In Vivo Synergistic Therapeutic Effect of Cisplatin with Human Papillomavirus16 E6/E7 CRISPR/Cas9 on Cervical Cancer Cell Line. Zhen S, Lu JJ, Wang LJ, Sun XM, Zhang JQ, Li X, Luo WJ, Zhao L. Transl Oncol. 2016 Dec;9(6):498-504. doi: 10.1016/j.tranon.2016.10.002. Epub 2016 Oct 28. PubMed |
| Smad Nuclear Interacting Protein 1 Acts as a Protective Regulator of Pressure Overload-Induced Pathological Cardiac Hypertrophy. Lu YY, Xu DC, Zhao YF, Zhu GF, Zhu MY, Liu WJ, Yu XJ, Chen W, Liu Z, Xu YW. J Am Heart Assoc. 2016 Oct 26;5(11). pii: e003943. PubMed |
| Variants of genes encoding collagens and matrix metalloproteinase system increased the risk of aortic dissection. Li Z, Zhou C, Tan L, Chen P, Cao Y, Li C, Li X, Yan J, Zeng H, Wang DW, Wang DW. Sci China Life Sci. 2017 Jan;60(1):57-65. doi: 10.1007/s11427-016-0333-3. Epub 2016 Dec 13. PubMed |
| Inhibition of long non-coding RNA UCA1 by CRISPR/Cas9 attenuated malignant phenotypes of bladder cancer. Zhen S, Hua L, Liu YH, Sun XM, Jiang MM, Chen W, Zhao L, Li X. Oncotarget. 2017 Feb 7;8(6):9634-9646. doi: 10.18632/oncotarget.14176. PubMed |
| Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBA/CaJ Mice. Fu X, Zhang L, Jin Y, Sun X, Zhang A, Wen Z, Zhou Y, Xia M, Gao J. Neural Plast. 2016;2016:6720420. doi: 10.1155/2016/6720420. Epub 2016 Dec 22. PubMed |
| CRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer. Su S, Zou Z, Chen F, Ding N, Du J, Shao J, Li L, Fu Y, Hu B, Yang Y, Sha H, Meng F, Wei J, Huang X, Liu B. Oncoimmunology. 2016 Nov 22;6(1):e1249558. doi: 10.1080/2162402X.2016.1249558. eCollection 2017. PubMed |
| ZNF307 (Zinc Finger Protein 307) Acts as a Negative Regulator of Pressure Overload-Induced Cardiac Hypertrophy. Yu CJ, Liang C, Li YX, Hu QQ, Zheng WW, Niu N, Yang X, Wang ZR, Yu XD, Zhang BL, Song BL, Zhang ZR. Hypertension. 2017 Apr;69(4):615-624. doi: 10.1161/HYPERTENSIONAHA.116.08500. Epub 2017 Feb 21. PubMed |
| CRISPR/Cas9-mediated ApoE-/- and LDLR-/- double gene knockout in pigs elevates serum LDL-C and TC levels. Huang L, Hua Z, Xiao H, Cheng Y, Xu K, Gao Q, Xia Y, Liu Y, Zhang X, Zheng X, Mu Y, Li K. Oncotarget. 2017 Jun 6;8(23):37751-37760. doi: 10.18632/oncotarget.17154. PubMed |
| RPL10L Is Required for Male Meiotic Division by Compensating for RPL10 during Meiotic Sex Chromosome Inactivation in Mice. Jiang L, Li T, Zhang X, Zhang B, Yu C, Li Y, Fan S, Jiang X, Khan T, Hao Q, Xu P, Nadano D, Huleihel M, Lunenfeld E, Wang PJ, Zhang Y, Shi Q. Curr Biol. 2017 May 22;27(10):1498-1505.e6. doi: 10.1016/j.cub.2017.04.017. Epub 2017 May 11. PubMed |
| USP13 negatively regulates antiviral responses by deubiquitinating STING. Sun H, Zhang Q, Jing YY, Zhang M, Wang HY, Cai Z, Liuyu T, Zhang ZD, Xiong TC, Wu Y, Zhu QY, Yao J, Shu HB, Lin D, Zhong B. Nat Commun. 2017 May 23;8:15534. doi: 10.1038/ncomms15534. PubMed |
| Efficient generation of goats with defined point mutation (I397V) in GDF9 through CRISPR/Cas9. Niu Y, Zhao X, Zhou J, Li Y, Huang Y, Cai B, Liu Y, Ding Q, Zhou S, Zhao J, Zhou G, Ma B, Huang X, Wang X, Chen Y. Reprod Fertil Dev. 2018 Jan;30(2):307-312. doi: 10.1071/RD17068. PubMed |
| Induction of INKIT by Viral Infection Negatively Regulates Antiviral Responses through Inhibiting Phosphorylation of p65 and IRF3. Lu B, Ren Y, Sun X, Han C, Wang H, Chen Y, Peng Q, Cheng Y, Cheng X, Zhu Q, Li W, Li HL, Du HN, Zhong B, Huang Z. Cell Host Microbe. 2017 Jul 12;22(1):86-98.e4. doi: 10.1016/j.chom.2017.06.013. PubMed |
| Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response. Xu J, Xu X, Wang B, Ma Y, Zhang L, Xu H, Hu Y, Wu J, Cao X. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8620-8625. doi: 10.1073/pnas.1700917114. Epub 2017 Jul 24. PubMed |
| CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Tang T, Lang X, Xu C, Wang X, Gong T, Yang Y, Cui J, Bai L, Wang J, Jiang W, Zhou R. Nat Commun. 2017 Aug 4;8(1):202. doi: 10.1038/s41467-017-00227-x. PubMed |
| Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis. Hsu PJ, Zhu Y, Ma H, Guo Y, Shi X, Liu Y, Qi M, Lu Z, Shi H, Wang J, Cheng Y, Luo G, Dai Q, Liu M, Guo X, Sha J, Shen B, He C. Cell Res. 2017 Sep;27(9):1115-1127. doi: 10.1038/cr.2017.99. Epub 2017 Aug 15. PubMed |
| Building Cre Knockin Rat Lines Using CRISPR/Cas9. Ma Y, Zhang L, Huang X. Methods Mol Biol. 2017;1642:37-52. doi: 10.1007/978-1-4939-7169-5_3. PubMed |
| DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining. Conlin MP, Reid DA, Small GW, Chang HH, Watanabe G, Lieber MR, Ramsden DA, Rothenberg E. Cell Rep. 2017 Sep 19;20(12):2810-2819. doi: 10.1016/j.celrep.2017.08.091. PubMed |
| Engineered cells for costimulatory enhancement combined with IL-21 enhance the generation of PD-1-disrupted CTLs for adoptive immunotherapy. Shao J, Xu Q, Su S, Meng F, Zou Z, Chen F, Du J, Qian X, Liu B. Cell Immunol. 2017 Oct;320:38-45. doi: 10.1016/j.cellimm.2017.09.003. Epub 2017 Sep 7. PubMed |
| MicroRNA-302a suppresses influenza A virus-stimulated interferon regulatory factor-5 expression and cytokine storm induction. Chen X, Zhou L, Peng N, Yu H, Li M, Cao Z, Lin Y, Wang X, Li Q, Wang J, She Y, Zhu C, Lu M, Zhu Y, Liu S. J Biol Chem. 2017 Dec 29;292(52):21291-21303. doi: 10.1074/jbc.M117.805937. Epub 2017 Oct 18. PubMed |
| PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. Tan GH, Liu YY, Wang L, Li K, Zhang ZQ, Li HF, Yang ZF, Li Y, Li D, Wu MY, Yu CL, Long JJ, Chen RC, Li LX, Yin LP, Liu JW, Cheng XW, Shen Q, Shu YS, Sakimura K, Liao LJ, Wu ZY, Xiong ZQ. Cell Res. 2018 Jan;28(1):90-110. doi: 10.1038/cr.2017.128. Epub 2017 Oct 20. PubMed |
| Zinc-finger protein 418 overexpression protects against cardiac hypertrophy and fibrosis. Pan L, Sheng M, Huang Z, Zhu Z, Xu C, Teng L, He L, Gu C, Yi C, Li J. PLoS One. 2017 Oct 24;12(10):e0186635. doi: 10.1371/journal.pone.0186635. eCollection 2017. PubMed |
| Generation of conditional Acvrl1 knockout mice by CRISPR/Cas9-mediated gene targeting. Xu M, Xu H, Chen J, Chen C, Xu F, Qin Z. Mol Cell Probes. 2018 Feb;37:32-38. doi: 10.1016/j.mcp.2017.11.003. Epub 2017 Nov 10. PubMed |
| CRISPR-offinder: a CRISPR guide RNA design and off-target searching tool for user-defined protospacer adjacent motif. Zhao C, Zheng X, Qu W, Li G, Li X, Miao YL, Han X, Liu X, Li Z, Ma Y, Shao Q, Li H, Sun F, Xie S, Zhao S. Int J Biol Sci. 2017 Nov 1;13(12):1470-1478. doi: 10.7150/ijbs.21312. eCollection 2017. PubMed |
| Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. Deng YZ, Cai Z, Shi S, Jiang H, Shang YR, Ma N, Wang JJ, Guan DX, Chen TW, Rong YF, Qian ZY, Zhang EB, Feng D, Zhou QL, Du YN, Liu DP, Huang XX, Liu LM, Chin E, Li DS, Wang XF, Zhang XL, Xie D. J Exp Med. 2018 Jan 2;215(1):177-195. doi: 10.1084/jem.20170399. Epub 2017 Dec 13. PubMed |
| APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks. Lei L, Chen H, Xue W, Yang B, Hu B, Wei J, Wang L, Cui Y, Li W, Wang J, Yan L, Shang W, Gao J, Sha J, Zhuang M, Huang X, Shen B, Yang L, Chen J. Nat Struct Mol Biol. 2018 Jan;25(1):45-52. doi: 10.1038/s41594-017-0004-6. Epub 2017 Dec 11. PubMed |
| Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination. Cui Y, Niu Y, Zhou J, Chen Y, Cheng Y, Li S, Ai Z, Chu C, Wang H, Zheng B, Chen X, Sha J, Guo X, Huang X, Ji W. Cell Res. 2018 Mar;28(3):383-386. doi: 10.1038/cr.2018.10. Epub 2018 Jan 12. PubMed |
| Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer. Yu H, Long W, Zhang X, Xu K, Guo J, Zhao H, Li H, Qing Y, Pan W, Jia B, Zhao HY, Huang X, Wei HJ. J Transl Med. 2018 Feb 27;16(1):41. doi: 10.1186/s12967-018-1409-7. PubMed |
| USP2a Supports Metastasis by Tuning TGF-beta Signaling. Zhao Y, Wang X, Wang Q, Deng Y, Li K, Zhang M, Zhang Q, Zhou J, Wang HY, Bai P, Ren Y, Zhang N, Li W, Cheng Y, Xiao W, Du HN, Cheng X, Yin L, Fu X, Lin D, Zhou Q, Zhong B. Cell Rep. 2018 Feb 27;22(9):2442-2454. doi: 10.1016/j.celrep.2018.02.007. PubMed |
| Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes. Bai S, Fu K, Yin H, Cui Y, Yue Q, Li W, Cheng L, Tan H, Liu X, Guo Y, Zhang Y, Xie J, He W, Wang Y, Feng H, Xin C, Zhang J, Lin M, Shen B, Sun Z, Guo X, Zheng K, Ye L. Development. 2018 Jul 4;145(13). pii: dev.164855. doi: 10.1242/dev.164855. PubMed |
| Correction of the Marfan Syndrome Pathogenic FBN1 Mutation by Base Editing in Human Cells and Heterozygous Embryos. Zeng Y, Li J, Li G, Huang S, Yu W, Zhang Y, Chen D, Chen J, Liu J, Huang X. Mol Ther. 2018 Nov 7;26(11):2631-2637. doi: 10.1016/j.ymthe.2018.08.007. Epub 2018 Aug 14. PubMed |
| BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N. Cell Rep. 2018 Sep 25;24(13):3513-3527.e7. doi: 10.1016/j.celrep.2018.08.086. PubMed |
| Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance. Wang L, Sun ZS, Xiang B, Wei CJ, Wang Y, Sun K, Chen G, Lan MS, Carmona GN, Notkins AL, Cai T. J Transl Med. 2018 Oct 25;16(1):297. doi: 10.1186/s12967-018-1665-6. PubMed |
| Defining multistep cell fate decision pathways during pancreatic development at single-cell resolution. Yu XX, Qiu WL, Yang L, Zhang Y, He MY, Li LC, Xu CR. EMBO J. 2019 Apr 15;38(8). pii: embj.2018100164. doi: 10.15252/embj.2018100164. Epub 2019 Feb 8. PubMed |
| Ubiquitin-specific protease 26 (USP26) is not essential for mouse gametogenesis and fertility. Felipe-Medina N, Gomez-H L, Condezo YB, Sanchez-Martin M, Barbero JL, Ramos I, Llano E, Pendas AM. Chromosoma. 2019 Mar 18. pii: 10.1007/s00412-019-00697-6. doi: 10.1007/s00412-019-00697-6. PubMed |
| Programmable Base Editing of the Sheep Genome Revealed No Genome-Wide Off-Target Mutations. Zhou S, Cai B, He C, Wang Y, Ding Q, Liu J, Liu Y, Ding Y, Zhao X, Li G, Li C, Yu H, Kou Q, Niu W, Petersen B, Sonstegard T, Ma B, Chen Y, Wang X. Front Genet. 2019 Mar 15;10:215. doi: 10.3389/fgene.2019.00215. eCollection 2019. PubMed |
| Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-kappaB signaling. Zhao H, Pan WM, Zhang HH, Song Y, Chen J, Xiang Y, Gu B, Li SZ, Du RL, Zhang XD. Cell Death Dis. 2019 Apr 3;10(4):304. doi: 10.1038/s41419-019-1537-x. PubMed |
| GIPC proteins negatively modulate Plexind1 signaling during vascular development. Carretero-Ortega J, Chhangawala Z, Hunt S, Narvaez C, Menendez-Gonzalez J, Gay CM, Zygmunt T, Li X, Torres-Vazquez J. Elife. 2019 May 3;8. pii: 30454. doi: 10.7554/eLife.30454. PubMed |
| LRRFIP1 expression triggers platelet agglutination by enhancing alphaIIbbeta3 expression. Yin X, Liu P, Liu YY, Liu MY, Fan WL, Liu BY, Zhao JH. Exp Ther Med. 2019 Jul;18(1):269-277. doi: 10.3892/etm.2019.7571. Epub 2019 May 10. PubMed |
| P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice. Liu G, Wang Y, Zheng W, Cheng H, Zhou R. Int J Biol Sci. 2019 May 20;15(7):1383-1395. doi: 10.7150/ijbs.33773. eCollection 2019. PubMed |
| Hepatectomy promotes recurrence of liver cancer by enhancing IL-11-STAT3 signaling. Wang D, Zheng X, Fu B, Nian Z, Qian Y, Sun R, Tian Z, Wei H. EBioMedicine. 2019 Aug;46:119-132. doi: 10.1016/j.ebiom.2019.07.058. Epub 2019 Jul 30. PubMed |
| IDH1 fine-tunes cap-dependent translation initiation. Liu L, Lu JY, Li F, Xing X, Li T, Yang X, Shen X. J Mol Cell Biol. 2019 Oct 25;11(10):816-828. doi: 10.1093/jmcb/mjz082. PubMed |
| The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility. Gomez-H L, Felipe-Medina N, Condezo YB, Garcia-Valiente R, Ramos I, Suja JA, Barbero JL, Roig I, Sanchez-Martin M, de Rooij DG, Llano E, Pendas AM. PLoS Genet. 2019 Aug 22;15(8):e1008316. doi: 10.1371/journal.pgen.1008316. eCollection 2019 Aug. PubMed |
| Roles of the hypoximir microRNA-424/322 in acute hypoxia and hypoxia-induced pulmonary vascular leakage. Tsai SH, Huang PH, Tsai HY, Hsu YJ, Chen YW, Wang JC, Chen YH, Lin SJ. FASEB J. 2019 Nov;33(11):12565-12575. doi: 10.1096/fj.201900564RR. Epub 2019 Aug 28. PubMed |
| Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing. Kumita W, Sato K, Suzuki Y, Kurotaki Y, Harada T, Zhou Y, Kishi N, Sato K, Aiba A, Sakakibara Y, Feng G, Okano H, Sasaki E. Sci Rep. 2019 Sep 3;9(1):12719. doi: 10.1038/s41598-019-49110-3. PubMed |
| Genetic determinants of cellular addiction to DNA polymerase theta. Feng W, Simpson DA, Carvajal-Garcia J, Price BA, Kumar RJ, Mose LE, Wood RD, Rashid N, Purvis JE, Parker JS, Ramsden DA, Gupta GP. Nat Commun. 2019 Sep 19;10(1):4286. doi: 10.1038/s41467-019-12234-1. PubMed |
| CDK2 kinase activity is a regulator of male germ cell fate. Singh P, Patel RK, Palmer N, Grenier JK, Paduch D, Kaldis P, Grimson A, Schimenti JC. Development. 2019 Nov 6;146(21). pii: dev.180273. doi: 10.1242/dev.180273. PubMed |
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