hCas9_D10A Citations (41)
Originally described in: RNA-Guided Human Genome Engineering via Cas9.Mali P, Yang L, Esvelt KM, Aach J, Guell M, Dicarlo JE, Norville JE, Church GM Science. 2013 Feb 15;339(6121):823-6. doi: 10.1126/science.1232033 PubMed Journal
Articles Citing hCas9_D10A
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An enChIP system for the analysis of bacterial genome functions.
Fujita T, Yuno M, Fujii H.
BMC Res Notes. 2018 Jun 14;11(1):387. doi: 10.1186/s13104-018-3486-3.
PubMed
Associated Plasmids |
| 3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells. Davidson L, Muniz L, West S. Genes Dev. 2014 Feb 15;28(4):342-56. doi: 10.1101/gad.231274.113. Epub 2014 Jan 29. PubMed |
| Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors. Hu J, Lei Y, Wong WK, Liu S, Lee KC, He X, You W, Zhou R, Guo JT, Chen X, Peng X, Sun H, Huang H, Zhao H, Feng B. Nucleic Acids Res. 2014 Apr;42(7):4375-90. doi: 10.1093/nar/gku109. Epub 2014 Feb 5. PubMed |
| Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system. Anton T, Bultmann S, Leonhardt H, Markaki Y. Nucleus. 2014 Mar-Apr;5(2):163-72. doi: 10.4161/nucl.28488. Epub 2014 Mar 12. PubMed |
| Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease. Kuscu C, Arslan S, Singh R, Thorpe J, Adli M. Nat Biotechnol. 2014 Jul;32(7):677-83. doi: 10.1038/nbt.2916. Epub 2014 May 18. PubMed |
Adenoviral vector delivery of RNA-guided CRISPR/Cas9 nuclease complexes induces targeted mutagenesis in a diverse array of human cells.
Maggio I, Holkers M, Liu J, Janssen JM, Chen X, Goncalves MA.
Sci Rep. 2014 May 29;4:5105. doi: 10.1038/srep05105.
PubMed
Associated Plasmids |
| Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system. Inui M, Miyado M, Igarashi M, Tamano M, Kubo A, Yamashita S, Asahara H, Fukami M, Takada S. Sci Rep. 2014 Jun 23;4:5396. doi: 10.1038/srep05396. PubMed |
| Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer. Zhou X, Xin J, Fan N, Zou Q, Huang J, Ouyang Z, Zhao Y, Zhao B, Liu Z, Lai S, Yi X, Guo L, Esteban MA, Zeng Y, Yang H, Lai L. Cell Mol Life Sci. 2015 Mar;72(6):1175-84. doi: 10.1007/s00018-014-1744-7. Epub 2014 Oct 2. PubMed |
| Assaying break and nick-induced homologous recombination in mammalian cells using the DR-GFP reporter and Cas9 nucleases. Vriend LE, Jasin M, Krawczyk PM. Methods Enzymol. 2014;546:175-91. doi: 10.1016/B978-0-12-801185-0.00009-X. PubMed |
| Creating a monomeric endonuclease TALE-I-SceI with high specificity and low genotoxicity in human cells. Lin J, Chen H, Luo L, Lai Y, Xie W, Kee K. Nucleic Acids Res. 2015 Jan;43(2):1112-22. doi: 10.1093/nar/gku1339. Epub 2014 Dec 24. PubMed |
| Fanconi anemia gene editing by the CRISPR/Cas9 system. Osborn MJ, Gabriel R, Webber BR, DeFeo AP, McElroy AN, Jarjour J, Starker CG, Wagner JE, Joung JK, Voytas DF, von Kalle C, Schmidt M, Blazar BR, Tolar J. Hum Gene Ther. 2015 Feb;26(2):114-26. doi: 10.1089/hum.2014.111. PubMed |
| A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture. O'Geen H, Henry IM, Bhakta MS, Meckler JF, Segal DJ. Nucleic Acids Res. 2015 Mar 31;43(6):3389-404. doi: 10.1093/nar/gkv137. Epub 2015 Feb 20. PubMed |
| Generation of mutant mice via the CRISPR/Cas9 system using FokI-dCas9. Hara S, Tamano M, Yamashita S, Kato T, Saito T, Sakuma T, Yamamoto T, Inui M, Takada S. Sci Rep. 2015 Jun 9;5:11221. doi: 10.1038/srep11221. PubMed |
| Generation of Hypertension-Associated STK39 Polymorphism Knockin Cell Lines With the Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 System. Mandai S, Mori T, Sohara E, Rai T, Uchida S. Hypertension. 2015 Dec;66(6):1199-206. doi: 10.1161/HYPERTENSIONAHA.115.05872. Epub 2015 Sep 28. PubMed |
Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair.
He X, Tan C, Wang F, Wang Y, Zhou R, Cui D, You W, Zhao H, Ren J, Feng B.
Nucleic Acids Res. 2016 May 19;44(9):e85. doi: 10.1093/nar/gkw064. Epub 2016 Feb 4.
PubMed
Associated Plasmids |
| Utilization of the CRISPR/Cas9 system for the efficient production of mutant mice using crRNA/tracrRNA with Cas9 nickase and FokI-dCas9. Terao M, Tamano M, Hara S, Kato T, Kinoshita M, Takada S. Exp Anim. 2016 Mar 14. PubMed |
| Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks, nicks and paired nicks. Vriend LE, Prakash R, Chen CC, Vanoli F, Cavallo F, Zhang Y, Jasin M, Krawczyk PM. Nucleic Acids Res. 2016 Jun 20;44(11):5204-17. doi: 10.1093/nar/gkw179. Epub 2016 Mar 21. PubMed |
| CRISPR/Cas9 Targeted Gene Editing and Cellular Engineering in Fanconi Anemia. Osborn M, Lonetree CL, Webber BR, Patel D, Dunmire S, McElroy AN, DeFeo AP, MacMillan ML, Wagner J, Balzar BR, Tolar J. Stem Cells Dev. 2016 Aug 18. PubMed |
| Targeted gene knock-in by CRISPR/Cas ribonucleoproteins in porcine zygotes. Park KE, Powell A, Sandmaier SE, Kim CM, Mileham A, Donovan DM, Telugu BP. Sci Rep. 2017 Feb 14;7:42458. doi: 10.1038/srep42458. PubMed |
A stable but reversible integrated surrogate reporter for assaying CRISPR/Cas9-stimulated homology-directed repair.
Wen Y, Liao G, Pritchard T, Zhao TT, Connelly JP, Pruett-Miller SM, Blanc V, Davidson NO, Madison BB.
J Biol Chem. 2017 Apr 14;292(15):6148-6162. doi: 10.1074/jbc.M117.777722. Epub 2017 Feb 22.
PubMed
Associated Plasmids |
| Mechanisms of precise genome editing using oligonucleotide donors. Kan Y, Ruis B, Takasugi T, Hendrickson EA. Genome Res. 2017 Jul;27(7):1099-1111. doi: 10.1101/gr.214775.116. Epub 2017 Mar 29. PubMed |
| An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome. Iefremova V, Manikakis G, Krefft O, Jabali A, Weynans K, Wilkens R, Marsoner F, Brandl B, Muller FJ, Koch P, Ladewig J. Cell Rep. 2017 Apr 4;19(1):50-59. doi: 10.1016/j.celrep.2017.03.047. PubMed |
| Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells. Koehler KR, Nie J, Longworth-Mills E, Liu XP, Lee J, Holt JR, Hashino E. Nat Biotechnol. 2017 Jun;35(6):583-589. doi: 10.1038/nbt.3840. Epub 2017 May 1. PubMed |
| Engineered Epidermal Progenitor Cells Can Correct Diet-Induced Obesity and Diabetes. Yue J, Gou X, Li Y, Wicksteed B, Wu X. Cell Stem Cell. 2017 Aug 3;21(2):256-263.e4. doi: 10.1016/j.stem.2017.06.016. PubMed |
| Evaluating different DNA binding domains to modulate L1 ORF2p-driven site-specific retrotransposition events in human cells. Ade CM, Derbes RS, Wagstaff BJ, Linker SB, White TB, Deharo D, Belancio VP, Ivics Z, Roy-Engel AM. Gene. 2018 Feb 5;642:188-198. doi: 10.1016/j.gene.2017.11.033. Epub 2017 Nov 14. PubMed |
| A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1. Boiers C, Richardson SE, Laycock E, Zriwil A, Turati VA, Brown J, Wray JP, Wang D, James C, Herrero J, Sitnicka E, Karlsson S, Smith AJH, Jacobsen SEW, Enver T. Dev Cell. 2018 Feb 5;44(3):362-377.e7. doi: 10.1016/j.devcel.2017.12.005. Epub 2017 Dec 28. PubMed |
| RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination. Ribeiro de Almeida C, Dhir S, Dhir A, Moghaddam AE, Sattentau Q, Meinhart A, Proudfoot NJ. Mol Cell. 2018 May 17;70(4):650-662.e8. doi: 10.1016/j.molcel.2018.04.001. Epub 2018 May 3. PubMed |
Efficiency and Specificity of Targeted Integration Mediated by the Adeno-Associated Virus Serotype 2 Rep 78 Protein.
Li P, Marino MP, Zou J, Argaw T, Morreale MT, Iaffaldano BJ, Reiser J.
Hum Gene Ther Methods. 2018 Jun;29(3):135-145. doi: 10.1089/hgtb.2018.052.
PubMed
Associated Plasmids |
A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs.
Pflueger C, Tan D, Swain T, Nguyen TV, Pflueger J, Nefzger C, Polo JM, Ford E, Lister R.
Genome Res. 2018 Jun 15. pii: gr.233049.117. doi: 10.1101/gr.233049.117.
PubMed
Associated Plasmids |
| Genome-edited skin epidermal stem cells protect mice from cocaine-seeking behaviour and cocaine overdose. Li Y, Kong Q, Yue J, Gou X, Xu M, Wu X. Nat Biomed Eng. 2019 Feb;3(2):105-113. doi: 10.1038/s41551-018-0293-z. Epub 2018 Sep 17. PubMed |
PCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells.
Sheng C, Mendler IH, Rieke S, Snyder P, Jentsch M, Friedrich D, Drossel B, Loewer A.
Cell Rep. 2019 Apr 2;27(1):48-58.e7. doi: 10.1016/j.celrep.2019.03.031.
PubMed
Associated Plasmids |
| Involvement of G-quadruplex regions in mammalian replication origin activity. Prorok P, Artufel M, Aze A, Coulombe P, Peiffer I, Lacroix L, Guedin A, Mergny JL, Damaschke J, Schepers A, Ballester B, Mechali M. Nat Commun. 2019 Jul 22;10(1):3274. doi: 10.1038/s41467-019-11104-0. PubMed |
| Targeted exon skipping with AAV-mediated split adenine base editors. Winter J, Luu A, Gapinske M, Manandhar S, Shirguppe S, Woods WS, Song JS, Perez-Pinera P. Cell Discov. 2019 Aug 20;5:41. doi: 10.1038/s41421-019-0109-7. eCollection 2019. PubMed |
| Sequential phosphorylation of NDEL1 by the DYRK2-GSK3beta complex is critical for neuronal morphogenesis. Woo Y, Kim SJ, Suh BK, Kwak Y, Jung HJ, Nhung TTM, Mun DJ, Hong JH, Noh SJ, Kim S, Lee A, Baek ST, Nguyen MD, Choe Y, Park SK. Elife. 2019 Dec 9;8. pii: 50850. doi: 10.7554/eLife.50850. PubMed |
| Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse. Bondarieva A, Raveendran K, Telychko V, Rao HBDP, Ravindranathan R, Zorzompokou C, Finsterbusch F, Dereli I, Papanikos F, Trankner D, Schleiffer A, Fei JF, Klimova A, Ito M, Kulkarni DS, Roeder I, Hunter N, Toth A. Nat Commun. 2020 Jun 18;11(1):3101. doi: 10.1038/s41467-020-16885-3. PubMed |
| The Rab32/BLOC-3-dependent pathway mediates host defense against different pathogens in human macrophages. Baldassarre M, Solano-Collado V, Balci A, Colamarino RA, Dambuza IM, Reid DM, Wilson HM, Brown GD, Mukhopadhyay S, Dougan G, Spano S. Sci Adv. 2021 Jan 15;7(3). pii: 7/3/eabb1795. doi: 10.1126/sciadv.abb1795. Print 2021 Jan. PubMed |
| PINK1 gene mutation by pair truncated sgRNA/Cas9-D10A in cynomolgus monkeys. Chen ZZ, Wang JY, Kang Y, Yang QY, Gu XY, Zhi DL, Yan L, Long CZ, Shen B, Niu YY. Zool Res. 2021 Jul 18;42(4):469-477. doi: 10.24272/j.issn.2095-8137.2021.023. PubMed |
| Quantitative Ubiquitylome Analysis Reveals the Specificity of RNF111/Arkadia E3 Ubiquitin Ligase for its Degradative Substrates SKI and SKIL/SnoN in TGF-beta Signaling Pathway. Laigle V, Dingli F, Amhaz S, Perron T, Chouchene M, Colasse S, Petit I, Poullet P, Loew D, Prunier C, Levy L. Mol Cell Proteomics. 2021;20:100173. doi: 10.1016/j.mcpro.2021.100173. Epub 2021 Nov 3. PubMed |
Find and cut-and-transfer (FiCAT) mammalian genome engineering.
Pallares-Masmitja M, Ivancic D, Mir-Pedrol J, Jaraba-Wallace J, Tagliani T, Oliva B, Rahmeh A, Sanchez-Mejias A, Guell M.
Nat Commun. 2021 Dec 3;12(1):7071. doi: 10.1038/s41467-021-27183-x.
PubMed
Associated Plasmids |
| Gulo gene locus, a new gene editing locus for mammalian cells. Habu T, Ishikawa H, Kim J. Biotechnol J. 2022 Jul;17(7):e2100493. doi: 10.1002/biot.202100493. Epub 2022 Apr 19. PubMed |
| CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids. Nie J, Ueda Y, Solivais AJ, Hashino E. Nat Commun. 2022 Nov 17;13(1):7053. doi: 10.1038/s41467-022-34759-8. PubMed |
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