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pCW57.1 Citations (154)

Originally described in: Root Lab pLEX and pLIX Gateway backbones
Unpublished

Articles Citing pCW57.1

Articles
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. Vietri M, Schink KO, Campsteijn C, Wegner CS, Schultz SW, Christ L, Thoresen SB, Brech A, Raiborg C, Stenmark H. Nature. 2015 Jun 11;522(7555):231-5. doi: 10.1038/nature14408. Epub 2015 Jun 3. PubMed
Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression. Barger CJ, Zhang W, Hillman J, Stablewski AB, Higgins MJ, Vanderhyden BC, Odunsi K, Karpf AR. Oncotarget. 2015 Jul 16. PubMed

Associated Plasmids

Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers. Momcilovic M, McMickle R, Abt E, Seki A, Simko SA, Magyar C, Stout DB, Fishbein MC, Walser TC, Dubinett SM, Shackelford DB. Cancer Res. 2015 Nov 15;75(22):4910-22. doi: 10.1158/0008-5472.CAN-15-0797. PubMed
ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission. Christ L, Wenzel EM, Liestol K, Raiborg C, Campsteijn C, Stenmark H. J Cell Biol. 2016 Feb 29;212(5):499-513. doi: 10.1083/jcb.201507009. PubMed
PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Brown A, Patel S, Ward C, Lorenz A, Ortiz M, DuRoss A, Wieghardt F, Esch A, Otten EG, Heiser LM, Korolchuk VI, Sun C, Sarkar S, Sahay G. Sci Rep. 2016 Aug 30;6:31750. doi: 10.1038/srep31750. PubMed
Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ. Oncogenesis. 2017 Jan 16;6(1):e287. doi: 10.1038/oncsis.2016.89. PubMed
Noncanonical function of DGCR8 controls mESC exit from pluripotency. Cirera-Salinas D, Yu J, Bodak M, Ngondo RP, Herbert KM, Ciaudo C. J Cell Biol. 2017 Jan 18. pii: jcb.201606073. doi: 10.1083/jcb.201606073. PubMed

Associated Plasmids

DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. Shadle SC, Zhong JW, Campbell AE, Conerly ML, Jagannathan S, Wong CJ, Morello TD, van der Maarel SM, Tapscott SJ. PLoS Genet. 2017 Mar 8;13(3):e1006658. doi: 10.1371/journal.pgen.1006658. eCollection 2017 Mar. PubMed

Associated Plasmids

CRISPR-Cas9 system-driven site-specific selection pressure on Herpes simplex virus genomes. Li Z, Bi Y, Xiao H, Sun L, Ren Y, Li Y, Chen C, Cun W. Virus Res. 2017 Mar 6. pii: S0168-1702(16)30694-3. doi: 10.1016/j.virusres.2017.03.010. PubMed
Kaposi's sarcoma-associated herpesvirus ORF34 is essential for late gene expression and virus production. Nishimura M, Watanabe T, Yagi S, Yamanaka T, Fujimuro M. Sci Rep. 2017 Mar 23;7(1):329. doi: 10.1038/s41598-017-00401-7. PubMed
Dissection of ubiquitinated protein degradation by basal autophagy. Takayama K, Matsuura A, Itakura E. FEBS Lett. 2017 May;591(9):1199-1211. doi: 10.1002/1873-3468.12641. Epub 2017 Apr 18. PubMed
Conservation and innovation in the DUX4-family gene network. Whiddon JL, Langford AT, Wong CJ, Zhong JW, Tapscott SJ. Nat Genet. 2017 Jun;49(6):935-940. doi: 10.1038/ng.3846. Epub 2017 May 1. PubMed

Associated Plasmids

Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons. Hendrickson PG, Dorais JA, Grow EJ, Whiddon JL, Lim JW, Wike CL, Weaver BD, Pflueger C, Emery BR, Wilcox AL, Nix DA, Peterson CM, Tapscott SJ, Carrell DT, Cairns BR. Nat Genet. 2017 Jun;49(6):925-934. doi: 10.1038/ng.3844. Epub 2017 May 1. PubMed
INTERACTION OF THE MINERALOCORTICOID RECEPTOR WITH RACK1 AND ITS ROLE IN ALDOSTERONE SIGNALING. Kuppusamy M, Gomez-Sanchez EP, Beloate LN, Plonczynski M, Naray-Fejes-Toth A, Fejes-Toth G, Gomez-Sanchez CE. Endocrinology. 2017 May 2. doi: 10.1210/en.2017-00095. PubMed
Extracellular Interactions between Hepatitis C Virus and Secreted Apolipoprotein E. Li Z, Li Y, Bi Y, Zhang H, Yao Y, Li Q, Cun W, Dong S. J Virol. 2017 Jul 12;91(15). pii: e02227-16. doi: 10.1128/JVI.02227-16. Print 2017 Aug 1. PubMed
The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity. Feng Q, Jagannathan S, Bradley RK. Mol Cell. 2017 Jul 20;67(2):239-251.e6. doi: 10.1016/j.molcel.2017.05.034. Epub 2017 Jun 29. PubMed

Associated Plasmids

Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1. Feng YX, Jin DX, Sokol ES, Reinhardt F, Miller DH, Gupta PB. Nat Commun. 2017 Oct 20;8(1):1079. doi: 10.1038/s41467-017-01052-y. PubMed
The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, Gonzalez-Prieto R, Xiao Z, Verlaan-de Vries M, Vertegaal ACO. Nat Commun. 2017 Nov 27;8(1):1809. doi: 10.1038/s41467-017-01900-x. PubMed
Cockayne's Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation. Epanchintsev A, Costanzo F, Rauschendorf MA, Caputo M, Ye T, Donnio LM, Proietti-de-Santis L, Coin F, Laugel V, Egly JM. Mol Cell. 2017 Dec 21;68(6):1054-1066.e6. doi: 10.1016/j.molcel.2017.11.009. Epub 2017 Dec 7. PubMed
KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation. Campbell M, Watanabe T, Nakano K, Davis RR, Lyu Y, Tepper CG, Durbin-Johnson B, Fujimuro M, Izumiya Y. Nat Commun. 2018 Jan 4;9(1):49. doi: 10.1038/s41467-017-02089-9. PubMed
Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I Molecules. Moser SC, Voerman JSA, Buckley DL, Winter GE, Schliehe C. Front Immunol. 2018 Jan 8;8:1920. doi: 10.3389/fimmu.2017.01920. eCollection 2017. PubMed
Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma. Zeid R, Lawlor MA, Poon E, Reyes JM, Fulciniti M, Lopez MA, Scott TG, Nabet B, Erb MA, Winter GE, Jacobson Z, Polaski DR, Karlin KL, Hirsch RA, Munshi NP, Westbrook TF, Chesler L, Lin CY, Bradner JE. Nat Genet. 2018 Apr;50(4):515-523. doi: 10.1038/s41588-018-0044-9. Epub 2018 Jan 29. PubMed
NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins. Campbell AE, Shadle SC, Jagannathan S, Lim JW, Resnick R, Tawil R, van der Maarel SM, Tapscott SJ. Elife. 2018 Mar 13;7. pii: 31023. doi: 10.7554/eLife.31023. PubMed

Associated Plasmids

DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins. Patel A, Yang P, Tinkham M, Pradhan M, Sun MA, Wang Y, Hoang D, Wolf G, Horton JR, Zhang X, Macfarlan T, Cheng X. Cell. 2018 Mar 22;173(1):221-233.e12. doi: 10.1016/j.cell.2018.02.058. Epub 2018 Mar 15. PubMed
Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth. Reichenbach B, Classon J, Aida T, Tanaka K, Genander M, Goritz C. EMBO J. 2018 May 2;37(9). pii: embj.201798280. doi: 10.15252/embj.201798280. Epub 2018 Apr 3. PubMed
A Raf-Competitive K-Ras Binder Can Fail to Functionally Antagonize Signaling. Kauke MJ, Tisdale AW, Kelly RL, Braun CJ, Hemann MT, Wittrup KD. Mol Cancer Ther. 2018 Aug;17(8):1773-1780. doi: 10.1158/1535-7163.MCT-17-0645. Epub 2018 May 2. PubMed
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. Zimmermann M, Murina O, Reijns MAM, Agathanggelou A, Challis R, Tarnauskaite Z, Muir M, Fluteau A, Aregger M, McEwan A, Yuan W, Clarke M, Lambros MB, Paneesha S, Moss P, Chandrashekhar M, Angers S, Moffat J, Brunton VG, Hart T, de Bono J, Stankovic T, Jackson AP, Durocher D. Nature. 2018 Jul;559(7713):285-289. doi: 10.1038/s41586-018-0291-z. Epub 2018 Jul 4. PubMed
Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism. Studd JB, Yang M, Li Z, Vijayakrishnan J, Lu Y, Yeoh AE, Paulsson K, Houlston RS. Leukemia. 2019 Jan;33(1):1-14. doi: 10.1038/s41375-018-0184-z. Epub 2018 Jul 6. PubMed
The shieldin complex mediates 53BP1-dependent DNA repair. Noordermeer SM, Adam S, Setiaputra D, Barazas M, Pettitt SJ, Ling AK, Olivieri M, Alvarez-Quilon A, Moatti N, Zimmermann M, Annunziato S, Krastev DB, Song F, Brandsma I, Frankum J, Brough R, Sherker A, Landry S, Szilard RK, Munro MM, McEwan A, Goullet de Rugy T, Lin ZY, Hart T, Moffat J, Gingras AC, Martin A, van Attikum H, Jonkers J, Lord CJ, Rottenberg S, Durocher D. Nature. 2018 Aug;560(7716):117-121. doi: 10.1038/s41586-018-0340-7. Epub 2018 Jul 18. PubMed

Associated Plasmids

Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores. Janssen LME, Averink TV, Blomen VA, Brummelkamp TR, Medema RH, Raaijmakers JA. Curr Biol. 2018 Sep 10;28(17):2685-2696.e4. doi: 10.1016/j.cub.2018.06.026. Epub 2018 Aug 16. PubMed
A Single Point Mutation in the Rhinovirus 2B Protein Reduces the Requirement for Phosphatidylinositol 4-Kinase Class III Beta in Viral Replication. Roulin PS, Murer LP, Greber UF. J Virol. 2018 Nov 12;92(23). pii: JVI.01462-18. doi: 10.1128/JVI.01462-18. Print 2018 Dec 1. PubMed
Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4. Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, Quaranta E, Di Biagio D, Sigismondo G, Guzzardo V, Lejeune P, Haendler B, Krijgsveld J, Fassan M, Bicciato S, Cordenonsi M, Piccolo S. Nat Med. 2018 Oct;24(10):1599-1610. doi: 10.1038/s41591-018-0158-8. Epub 2018 Sep 17. PubMed
Src kinase phosphorylates Notch1 to inhibit MAML binding. LaFoya B, Munroe JA, Pu X, Albig AR. Sci Rep. 2018 Oct 19;8(1):15515. doi: 10.1038/s41598-018-33920-y. PubMed
INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. Elife. 2018 Oct 25;7. pii: 38539. doi: 10.7554/eLife.38539. PubMed
The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling. Massa F, Tammaro R, Prado MA, Cesana M, Lee BH, Finley D, Franco B, Morleo M. Hum Mol Genet. 2019 Mar 1;28(5):764-777. doi: 10.1093/hmg/ddy380. PubMed
The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S. Nature. 2018 Nov;563(7730):265-269. doi: 10.1038/s41586-018-0658-1. Epub 2018 Oct 31. PubMed
Subtype-specific regulatory network rewiring in acute myeloid leukemia. Assi SA, Imperato MR, Coleman DJL, Pickin A, Potluri S, Ptasinska A, Chin PS, Blair H, Cauchy P, James SR, Zacarias-Cabeza J, Gilding LN, Beggs A, Clokie S, Loke JC, Jenkin P, Uddin A, Delwel R, Richards SJ, Raghavan M, Griffiths MJ, Heidenreich O, Cockerill PN, Bonifer C. Nat Genet. 2019 Jan;51(1):151-162. doi: 10.1038/s41588-018-0270-1. Epub 2018 Nov 12. PubMed
Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression. Mowery CT, Reyes JM, Cabal-Hierro L, Higby KJ, Karlin KL, Wang JH, Kimmerling RJ, Cejas P, Lim K, Li H, Furusawa T, Long HW, Pellman D, Chapuy B, Bustin M, Manalis SR, Westbrook TF, Lin CY, Lane AA. Cell Rep. 2018 Nov 13;25(7):1898-1911.e5. doi: 10.1016/j.celrep.2018.10.061. PubMed
S-Palmitoylation Sorts Membrane Cargo for Anterograde Transport in the Golgi. Ernst AM, Syed SA, Zaki O, Bottanelli F, Zheng H, Hacke M, Xi Z, Rivera-Molina F, Graham M, Rebane AA, Bjorkholm P, Baddeley D, Toomre D, Pincet F, Rothman JE. Dev Cell. 2018 Nov 19;47(4):479-493.e7. doi: 10.1016/j.devcel.2018.10.024. PubMed
Nucleus-localized adiponectin is survival gatekeeper through miR-214-mediated AIFM2 regulation. Cho J, Teshigawara R, Kameda M, Yamaguchi S, Tada T. Genes Cells. 2019 Feb;24(2):126-138. doi: 10.1111/gtc.12658. Epub 2019 Jan 2. PubMed
Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma. Edginton-White B, Cauchy P, Assi SA, Hartmann S, Riggs AG, Mathas S, Cockerill PN, Bonifer C. Leukemia. 2018 Dec 13. pii: 10.1038/s41375-018-0311-x. doi: 10.1038/s41375-018-0311-x. PubMed
TRB1 negatively regulates gluconeogenesis by suppressing the transcriptional activity of FOXO1. Tsuzuki K, Itoh Y, Inoue Y, Hayashi H. FEBS Lett. 2019 Feb;593(3):369-380. doi: 10.1002/1873-3468.13314. Epub 2019 Jan 8. PubMed
A comparison of resveratrol and other polyphenolic compounds on Notch activation and endothelial cell activity. LaFoya B, Munroe JA, Albig AR. PLoS One. 2019 Jan 17;14(1):e0210607. doi: 10.1371/journal.pone.0210607. eCollection 2019. PubMed
Follicular lymphoma-associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and mTOR. Wang F, Gatica D, Ying ZX, Peterson LF, Kim P, Bernard D, Saiya-Cork K, Wang S, Kaminski MS, Chang AE, Phillips T, Klionsky DJ, Malek SN. J Clin Invest. 2019 Mar 4;130:1626-1640. doi: 10.1172/JCI98288. eCollection 2019 Mar 4. PubMed
MDM2 and MDM4 are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors. Howard TP, Arnoff TE, Song MR, Giacomelli AO, Wang X, Hong AL, Dharia NV, Wang S, Vazquez F, Pham MT, Morgan AM, Wachter F, Bird GH, Kugener G, Oberlick EM, Rees MG, Tiv HL, Hwang JH, Walsh KH, Cook A, Krill-Burger JM, Tsherniak A, Gokhale PC, Park PJ, Stegmaier K, Walensky LD, Hahn WC, Roberts CWM. Cancer Res. 2019 Feb 12. pii: 0008-5472.CAN-18-3066. doi: 10.1158/0008-5472.CAN-18-3066. PubMed

Associated Plasmids

Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer. Barger CJ, Branick C, Chee L, Karpf AR. Cancers (Basel). 2019 Feb 21;11(2). pii: cancers11020251. doi: 10.3390/cancers11020251. PubMed

Associated Plasmids

Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding. Li S, Chen K, Zhang Y, Barnes SD, Jaichander P, Zheng Y, Hassan M, Malladi VS, Skapek SX, Xu L, Bassel-Duby R, Olson EN, Liu N. Genes Dev. 2019 Jun 1;33(11-12):626-640. doi: 10.1101/gad.324467.119. Epub 2019 Apr 11. PubMed
OVOL2 induces mesenchymal-to-epithelial transition in fibroblasts and enhances cell-state reprogramming towards epithelial lineages. Watanabe K, Liu Y, Noguchi S, Murray M, Chang JC, Kishima M, Nishimura H, Hashimoto K, Minoda A, Suzuki H. Sci Rep. 2019 Apr 24;9(1):6490. doi: 10.1038/s41598-019-43021-z. PubMed
Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer. Parolia A, Cieslik M, Chu SC, Xiao L, Ouchi T, Zhang Y, Wang X, Vats P, Cao X, Pitchiaya S, Su F, Wang R, Feng FY, Wu YM, Lonigro RJ, Robinson DR, Chinnaiyan AM. Nature. 2019 Jul;571(7765):413-418. doi: 10.1038/s41586-019-1347-4. Epub 2019 Jun 26. PubMed
A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription. Platanitis E, Demiroz D, Schneller A, Fischer K, Capelle C, Hartl M, Gossenreiter T, Muller M, Novatchkova M, Decker T. Nat Commun. 2019 Jul 2;10(1):2921. doi: 10.1038/s41467-019-10970-y. PubMed
How to Choose the Right Inducible Gene Expression System for Mammalian Studies? Kallunki T, Barisic M, Jaattela M, Liu B. Cells. 2019 Jul 30;8(8). pii: cells8080796. doi: 10.3390/cells8080796. PubMed
Identification of a factor controlling lysosomal homeostasis using a novel lysosomal trafficking probe. Ishii S, Matsuura A, Itakura E. Sci Rep. 2019 Aug 12;9(1):11635. doi: 10.1038/s41598-019-48131-2. PubMed

Associated Plasmids

Control of homologous recombination by the HROB-MCM8-MCM9 pathway. Hustedt N, Saito Y, Zimmermann M, Alvarez-Quilon A, Setiaputra D, Adam S, McEwan A, Yuan JY, Olivieri M, Zhao Y, Kanemaki MT, Jurisicova A, Durocher D. Genes Dev. 2019 Oct 1;33(19-20):1397-1415. doi: 10.1101/gad.329508.119. Epub 2019 Aug 29. PubMed

Associated Plasmids

A consensus set of genetic vulnerabilities to ATR inhibition. Hustedt N, Alvarez-Quilon A, McEwan A, Yuan JY, Cho T, Koob L, Hart T, Durocher D. Open Biol. 2019 Sep 27;9(9):190156. doi: 10.1098/rsob.190156. Epub 2019 Sep 11. PubMed
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Samir P, Kesavardhana S, Patmore DM, Gingras S, Malireddi RKS, Karki R, Guy CS, Briard B, Place DE, Bhattacharya A, Sharma BR, Nourse A, King SV, Pitre A, Burton AR, Pelletier S, Gilbertson RJ, Kanneganti TD. Nature. 2019 Sep;573(7775):590-594. doi: 10.1038/s41586-019-1551-2. Epub 2019 Sep 11. PubMed
UL26 Attenuates IKKbeta-Mediated Induction of Interferon-Stimulated Gene (ISG) Expression and Enhanced Protein ISGylation during Human Cytomegalovirus Infection. Goodwin CM, Schafer X, Munger J. J Virol. 2019 Nov 13;93(23). pii: JVI.01052-19. doi: 10.1128/JVI.01052-19. Print 2019 Dec 1. PubMed
BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis. Huang K, O'Neill KL, Li J, Zhou W, Han N, Pang X, Wu W, Struble L, Borgstahl G, Liu Z, Zhang L, Luo X. Cell Res. 2019 Nov;29(11):942-952. doi: 10.1038/s41422-019-0231-y. Epub 2019 Sep 24. PubMed
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massague J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26. PubMed
MX 2 is a novel regulator of cell cycle in melanoma cells. Juraleviciute M, Pozniak J, Nsengimana J, Harland M, Randerson-Moor J, Wernhoff P, Bassarova A, Oy GF, Troen G, Florenes VA, Bishop DT, Herlyn M, Newton-Bishop J, Slipicevic A. Pigment Cell Melanoma Res. 2019 Oct 29. doi: 10.1111/pcmr.12837. PubMed
Reprogramming of DNA methylation at NEUROD2-bound sequences during cortical neuron differentiation. Hahn MA, Jin SG, Li AX, Liu J, Huang Z, Wu X, Kim BW, Johnson J, Bilbao AV, Tao S, Yim JA, Fong Y, Goebbels S, Schwab MH, Lu Q, Pfeifer GP. Sci Adv. 2019 Oct 23;5(10):eaax0080. doi: 10.1126/sciadv.aax0080. eCollection 2019 Oct. PubMed
DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression. Resnick R, Wong CJ, Hamm DC, Bennett SR, Skene PJ, Hake SB, Henikoff S, van der Maarel SM, Tapscott SJ. Cell Rep. 2019 Nov 12;29(7):1812-1820.e5. doi: 10.1016/j.celrep.2019.10.025. PubMed
Enhanced lysosomal degradation maintains the quiescent state of neural stem cells. Kobayashi T, Piao W, Takamura T, Kori H, Miyachi H, Kitano S, Iwamoto Y, Yamada M, Imayoshi I, Shioda S, Ballabio A, Kageyama R. Nat Commun. 2019 Nov 29;10(1):5446. doi: 10.1038/s41467-019-13203-4. PubMed
The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex. Bauer M, Flatt JW, Seiler D, Cardel B, Emmenlauer M, Boucke K, Suomalainen M, Hemmi S, Greber UF. Cell Rep. 2019 Dec 17;29(12):3785-3795.e8. doi: 10.1016/j.celrep.2019.11.064. PubMed

Associated Plasmids

Interferon mediated neuroinflammation in polyglutamine disease is not caused by RNA toxicity. Bhambri A, Pinto A, Pillai B. Cell Death Dis. 2020 Jan 2;11(1):3. doi: 10.1038/s41419-019-2193-x. PubMed
Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence. Miyajima C, Kawarada Y, Inoue Y, Suzuki C, Mitamura K, Morishita D, Ohoka N, Imamura T, Hayashi H. Cells. 2020 Jan 9;9(1). pii: cells9010171. doi: 10.3390/cells9010171. PubMed
Codon optimization is an essential parameter for the efficient allotopic expression of mtDNA genes. Lewis CJ, Dixit B, Batiuk E, Hall CJ, O'Connor MS, Boominathan A. Redox Biol. 2020 Feb;30:101429. doi: 10.1016/j.redox.2020.101429. Epub 2020 Jan 11. PubMed
Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2. Morita K, He S, Nowak RP, Wang J, Zimmerman MW, Fu C, Durbin AD, Martel MW, Prutsch N, Gray NS, Fischer ES, Look AT. Cell. 2020 Apr 30;181(3):702-715.e20. doi: 10.1016/j.cell.2020.03.051. Epub 2020 Apr 20. PubMed
HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis. Bai G, Kermi C, Stoy H, Schiltz CJ, Bacal J, Zaino AM, Hadden MK, Eichman BF, Lopes M, Cimprich KA. Mol Cell. 2020 Jun 18;78(6):1237-1251.e7. doi: 10.1016/j.molcel.2020.04.031. Epub 2020 May 21. PubMed
Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Alvarez-Quilon A, Wojtaszek JL, Mathieu MC, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Munoz IM, Grazzini E, Young JTF, Rouse J, Zinda M, Williams RS, Durocher D. Mol Cell. 2020 Jun 18;78(6):1152-1165.e8. doi: 10.1016/j.molcel.2020.05.021. Epub 2020 Jun 8. PubMed
Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation. Xie L, Hu WY, Hu DP, Shi G, Li Y, Yang J, Prins GS. Environ Health Perspect. 2020 Jun;128(6):67008. doi: 10.1289/EHP6471. Epub 2020 Jun 11. PubMed
Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase. Abdisalaam S, Bhattacharya S, Mukherjee S, Sinha D, Srinivasan K, Zhu M, Akbay EA, Sadek HA, Shay JW, Asaithamby A. J Biol Chem. 2020 Aug 7;295(32):11144-11160. doi: 10.1074/jbc.RA120.012962. Epub 2020 Jun 15. PubMed
FGFR1 Is Critical for RBL2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer. Kim KB, Kim Y, Rivard CJ, Kim DW, Park KS. Cancer Res. 2020 Nov 15;80(22):5051-5062. doi: 10.1158/0008-5472.CAN-20-1453. Epub 2020 Sep 24. PubMed
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling. Fedele C, Li S, Teng KW, Foster CJR, Peng D, Ran H, Mita P, Geer MJ, Hattori T, Koide A, Wang Y, Tang KH, Leinwand J, Wang W, Diskin B, Deng J, Chen T, Dolgalev I, Ozerdem U, Miller G, Koide S, Wong KK, Neel BG. J Exp Med. 2021 Jan 4;218(1). pii: 211451. doi: 10.1084/jem.20201414. PubMed
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import. Girardi E, Agrimi G, Goldmann U, Fiume G, Lindinger S, Sedlyarov V, Srndic I, Gurtl B, Agerer B, Kartnig F, Scarcia P, Di Noia MA, Lineiro E, Rebsamen M, Wiedmer T, Bergthaler A, Palmieri L, Superti-Furga G. Nat Commun. 2020 Dec 1;11(1):6145. doi: 10.1038/s41467-020-19871-x. PubMed
Massively parallel functional testing of MSH2 missense variants conferring Lynch syndrome risk. Jia X, Burugula BB, Chen V, Lemons RM, Jayakody S, Maksutova M, Kitzman JO. Am J Hum Genet. 2021 Jan 7;108(1):163-175. doi: 10.1016/j.ajhg.2020.12.003. Epub 2020 Dec 23. PubMed
Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers. Head SA, Hernandez-Alias X, Yang JS, Ciampi L, Beltran-Sastre V, Torres-Mendez A, Irimia M, Schaefer MH, Serrano L. PLoS Biol. 2021 Feb 23;19(2):e3001138. doi: 10.1371/journal.pbio.3001138. eCollection 2021 Feb. PubMed
Caspase-9 acts as a regulator of necroptotic cell death. Molnar T, Pallagi P, Tel B, Kiraly R, Csoma E, Jenei V, Varga Z, Gogolak P, Odile Hueber A, Mate Z, Erdelyi F, Szabo G, Pettko-Szandtner A, Bacsi A, Virag L, Maleth J, Koncz G. FEBS J. 2021 Apr 25. doi: 10.1111/febs.15898. PubMed
RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness. Benitez S, Cordero A, Santamaria PG, Redondo-Pedraza J, Rocha AS, Collado-Sole A, Jimenez M, Sanz-Moreno A, Yoldi G, Santos JC, De Benedictis I, Gomez-Aleza C, Da Silva-Alvarez S, Troule K, Gomez-Lopez G, Alcazar N, Palmero I, Collado M, Serrano M, Gonzalez-Suarez E. Dev Cell. 2021 Jun 21;56(12):1727-1741.e7. doi: 10.1016/j.devcel.2021.04.022. Epub 2021 May 17. PubMed
Suppression of Breast Cancer by Small Molecules That Block the Prolactin Receptor. Borcherding DC, Hugo ER, Fox SR, Jacobson EM, Hunt BG, Merino EJ, Ben-Jonathan N. Cancers (Basel). 2021 May 28;13(11). pii: cancers13112662. doi: 10.3390/cancers13112662. PubMed
Drug-like sphingolipid SH-BC-893 opposes ceramide-induced mitochondrial fission and corrects diet-induced obesity. Jayashankar V, Selwan E, Hancock SE, Verlande A, Goodson MO, Eckenstein KH, Milinkeviciute G, Hoover BM, Chen B, Fleischman AG, Cramer KS, Hanessian S, Masri S, Turner N, Edinger AL. EMBO Mol Med. 2021 Aug 9;13(8):e13086. doi: 10.15252/emmm.202013086. Epub 2021 Jul 7. PubMed
The multi-functional reovirus sigma3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury. Guo Y, Hinchman MM, Lewandrowski M, Cross ST, Sutherland DM, Welsh OL, Dermody TS, Parker JSL. PLoS Pathog. 2021 Jul 8;17(7):e1009494. doi: 10.1371/journal.ppat.1009494. eCollection 2021 Jul. PubMed
A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation. Zhang W, Yang X, Chen L, Liu YY, Venkatarangan V, Reist L, Hanson P, Xu H, Wang Y, Li M. PLoS Biol. 2021 Jul 23;19(7):e3001361. doi: 10.1371/journal.pbio.3001361. eCollection 2021 Jul. PubMed
BHLHE40 Regulates IL-10 and IFN-gamma Production in T Cells but Does Not Interfere With Human Type 1 Regulatory T Cell Differentiation. Uyeda MJ, Freeborn RA, Cieniewicz B, Romano R, Chen PP, Liu JM, Thomas B, Lee E, Cepika AM, Bacchetta R, Roncarolo MG. Front Immunol. 2021 Jul 7;12:683680. doi: 10.3389/fimmu.2021.683680. eCollection 2021. PubMed
The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection. Li J, Nagy N, Liu J, Gupta S, Frisan T, Hennig T, Cameron DP, Baranello L, Masucci MG. PLoS Pathog. 2021 Sep 20;17(9):e1009954. doi: 10.1371/journal.ppat.1009954. eCollection 2021 Sep. PubMed
11betaHSD2 Efficacy in Preventing Transcriptional Activation of the Mineralocorticoid Receptor by Corticosterone. Ali Y, Kuppusamy M, Velarde-Miranda C, Gomez-Sanchez CM, Plonczynski M, Gomez-Sanchez CE, Gomez-Sanchez EP. J Endocr Soc. 2021 Sep 3;5(11):bvab146. doi: 10.1210/jendso/bvab146. eCollection 2021 Nov 1. PubMed
Labeling and measuring stressed mitochondria using a PINK1-based ratiometric fluorescent sensor. Uesugi R, Ishii S, Matsuura A, Itakura E. J Biol Chem. 2021 Nov;297(5):101279. doi: 10.1016/j.jbc.2021.101279. Epub 2021 Oct 5. PubMed
TEC kinase stabilizes PLK4 to promote liver cancer metastasis. Yeung SF, Zhou Y, Zou W, Chan WL, Ching YP. Cancer Lett. 2022 Jan 1;524:70-81. doi: 10.1016/j.canlet.2021.08.038. Epub 2021 Oct 9. PubMed
Benzyl-para-di-[5-methyl-4-(n-octylamino) pyrimidin-2(1H)one] as an interferon beta (IFN-beta) modulator. Trifonov L, Yurchenko M, Skjesol A, Cohen G, Espevik T, Korshin EE, Grovdal LM, Husebye H, Gruzman A. Mol Divers. 2021 Oct 19. pii: 10.1007/s11030-021-10324-1. doi: 10.1007/s11030-021-10324-1. PubMed
UBR7 acts as a histone chaperone for post-nucleosomal histone H3. Hogan AK, Sathyan KM, Willis AB, Khurana S, Srivastava S, Zasadzinska E, Lee AS, Bailey AO, Gaynes MN, Huang J, Bodner J, Rosencrance CD, Wong KA, Morgan MA, Eagen KP, Shilatifard A, Foltz DR. EMBO J. 2021 Dec 15;40(24):e108307. doi: 10.15252/embj.2021108307. Epub 2021 Nov 17. PubMed
The Endoplasmic Reticulum Stress Sensor IRE1alpha Regulates the UV DNA Repair Response through the Control of Intracellular Calcium Homeostasis. Son J, Mogre S, Chalmers FE, Ibinson J, Worrell S, Glick AB. J Invest Dermatol. 2021 Nov 20. pii: S0022-202X(21)02508-2. doi: 10.1016/j.jid.2021.11.010. PubMed
A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer. Liu Y, Wu Z, Zhou J, Ramadurai DKA, Mortenson KL, Aguilera-Jimenez E, Yan Y, Yang X, Taylor AM, Varley KE, Gertz J, Choi PS, Cherniack AD, Chen X, Bass AJ, Bailey SD, Zhang X. Nat Commun. 2021 Dec 8;12(1):7139. doi: 10.1038/s41467-021-27055-4. PubMed
Disruption of actin dynamics induces autophagy of the eukaryotic chaperonin TRiC/CCT. Date Y, Matsuura A, Itakura E. Cell Death Discov. 2022 Jan 25;8(1):37. doi: 10.1038/s41420-022-00828-6. PubMed
KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer. Kim KB, Kabra A, Kim DW, Xue Y, Huang Y, Hou PC, Zhou Y, Miranda LJ, Park JI, Shi X, Bender TP, Bushweller JH, Park KS. Sci Adv. 2022 Feb 18;8(7):eabl4618. doi: 10.1126/sciadv.abl4618. Epub 2022 Feb 16. PubMed
TRACE-seq: A transgenic system for unbiased and non-invasive transcriptome profiling of living cells. Cherbonneau F, Li G, Gokulnath P, Sahu P, Prunevieille A, Kitchen R, Benichou G, Larghero J, Domian I, Das S. iScience. 2022 Jan 25;25(2):103806. doi: 10.1016/j.isci.2022.103806. eCollection 2022 Feb 18. PubMed
N-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion. Hobohm L, Koudelka T, Bahr FH, Truberg J, Kapell S, Schacht SS, Meisinger D, Mengel M, Jochimsen A, Hofmann A, Heintz L, Tholey A, Voss M. Cell Mol Life Sci. 2022 Mar 13;79(3):185. doi: 10.1007/s00018-022-04163-y. PubMed
Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency. Wang F, Yang Y, Boudagh G, Eskelinen EL, Klionsky DJ, Malek SN. Autophagy. 2022 Aug;18(8):1982-2000. doi: 10.1080/15548627.2022.2050663. Epub 2022 Mar 24. PubMed
Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation. Chen Z, Ioris RM, Richardson S, Van Ess AN, Vendrell I, Kessler BM, Buffa FM, Busino L, Clifford SC, Bullock AN, D'Angiolella V. Cell Death Differ. 2022 Apr 4. pii: 10.1038/s41418-022-00983-4. doi: 10.1038/s41418-022-00983-4. PubMed

Associated Plasmids

Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis. Wang D, Tanaka-Yano M, Meader E, Kinney MA, Morris V, Lummertz da Rocha E, Liu N, Liu T, Zhu Q, Orkin SH, North TE, Daley GQ, Rowe RG. Cell Rep. 2022 Apr 5;39(1):110587. doi: 10.1016/j.celrep.2022.110587. PubMed

Associated Plasmids

Data-driven learning how oncogenic gene expression locally alters heterocellular networks. Klinke DJ II, Fernandez A, Deng W, Razazan A, Latifizadeh H, Pirkey AC. Nat Commun. 2022 Apr 13;13(1):1986. doi: 10.1038/s41467-022-29636-3. PubMed
A Single Transcript Knockdown-Replacement Strategy Employing 5' UTR Secondary Structures to Precisely Titrate Rescue Protein Translation. Millette MM, Holland ED, Tenpas TJ, Dent EW. Front Genome Ed. 2022 Mar 28;4:803375. doi: 10.3389/fgeed.2022.803375. eCollection 2022. PubMed

Associated Plasmids

ROR activation by Nobiletin enhances antitumor efficacy via suppression of IkappaB/NF-kappaB signaling in triple-negative breast cancer. Kim E, Kim YJ, Ji Z, Kang JM, Wirianto M, Paudel KR, Smith JA, Ono K, Kim JA, Eckel-Mahan K, Zhou X, Lee HK, Yoo JY, Yoo SH, Chen Z. Cell Death Dis. 2022 Apr 19;13(4):374. doi: 10.1038/s41419-022-04826-5. PubMed
CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition. Gallo D, Young JTF, Fourtounis J, Martino G, Alvarez-Quilon A, Bernier C, Duffy NM, Papp R, Roulston A, Stocco R, Szychowski J, Veloso A, Alam H, Baruah PS, Fortin AB, Bowlan J, Chaudhary N, Desjardins J, Dietrich E, Fournier S, Fugere-Desjardins C, Goullet de Rugy T, Leclaire ME, Liu B, Bhaskaran V, Mamane Y, Melo H, Nicolas O, Singhania A, Szilard RK, Tkac J, Yin SY, Morris SJ, Zinda M, Marshall CG, Durocher D. Nature. 2022 Apr;604(7907):749-756. doi: 10.1038/s41586-022-04638-9. Epub 2022 Apr 20. PubMed
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells. Morris V, Wang D, Li Z, Marion W, Hughes T, Sousa P, Harada T, Sui SH, Naumenko S, Kalfon J, Sensharma P, Falchetti M, Vinicius da Silva R, Candelli T, Schneider P, Margaritis T, Holstege FCP, Pikman Y, Harris M, Stam RW, Orkin SH, Koehler AN, Shalek AK, North TE, Pimkin M, Daley GQ, Lummertz da Rocha E, Rowe RG. Cell Rep. 2022 Apr 26;39(4):110752. doi: 10.1016/j.celrep.2022.110752. PubMed
Breakage of cytoplasmic chromosomes by pathological DNA base excision repair. Tang S, Stokasimov E, Cui Y, Pellman D. Nature. 2022 Jun;606(7916):930-936. doi: 10.1038/s41586-022-04767-1. Epub 2022 Apr 27. PubMed
ALKBH5 regulates somatic cell reprogramming in a phase-specific manner. Khodeer S, Klungland A, Dahl JA. J Cell Sci. 2022 Jun 1;135(11). pii: 275396. doi: 10.1242/jcs.259824. Epub 2022 Jun 10. PubMed
TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes. Verma M, Loh NY, Sabaratnam R, Vasan SK, van Dam AD, Todorcevic M, Neville MJ, Toledo E, Karpe F, Christodoulides C. Metabolism. 2022 Aug;133:155240. doi: 10.1016/j.metabol.2022.155240. Epub 2022 Jun 10. PubMed
Cystathionine-beta-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation. Zhu H, Chan KT, Huang X, Cerra C, Blake S, Trigos AS, Anderson D, Creek DJ, De Souza DP, Wang X, Fu C, Jana M, Sanij E, Pearson RB, Kang J. Elife. 2022 Jun 27;11. pii: 71929. doi: 10.7554/eLife.71929. PubMed
YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING. Sladitschek-Martens HL, Guarnieri A, Brumana G, Zanconato F, Battilana G, Xiccato RL, Panciera T, Forcato M, Bicciato S, Guzzardo V, Fassan M, Ulliana L, Gandin A, Tripodo C, Foiani M, Brusatin G, Cordenonsi M, Piccolo S. Nature. 2022 Jul;607(7920):790-798. doi: 10.1038/s41586-022-04924-6. Epub 2022 Jun 29. PubMed
Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently. Kim S, Park HS, Oh BH. Comput Struct Biotechnol J. 2022 Jun 14;20:3019-3029. doi: 10.1016/j.csbj.2022.06.021. eCollection 2022. PubMed
A Quantitative Assay for Ca(2+) Uptake through Normal and Pathological Hemichannels. Nardin C, Tettey-Matey A, Donati V, Marazziti D, Di Pietro C, Peres C, Raspa M, Zonta F, Yang G, Gorelik M, Singh S, Cardarelli L, Sidhu SS, Mammano F. Int J Mol Sci. 2022 Jun 30;23(13). pii: ijms23137337. doi: 10.3390/ijms23137337. PubMed
AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer. Kim S, Au CC, Jamalruddin MAB, Abou-Ghali NE, Mukhtar E, Portella L, Berger A, Worroll D, Vatsa P, Rickman DS, Nanus DM, Giannakakou P. Elife. 2022 Jul 18;11:e73396. doi: 10.7554/eLife.73396. PubMed
YES1 Is a Druggable Oncogenic Target in SCLC. Redin E, Garrido-Martin EM, Valencia K, Redrado M, Solorzano JL, Carias R, Echepare M, Exposito F, Serrano D, Ferrer I, Nunez-Buiza A, Garmendia I, Garcia-Pedrero JM, Gurpide A, Paz-Ares L, Politi K, Montuenga LM, Calvo A. J Thorac Oncol. 2022 Dec;17(12):1387-1403. doi: 10.1016/j.jtho.2022.08.002. Epub 2022 Aug 18. PubMed
Knockouts of TUT7 and 3'hExo show that they cooperate in histone mRNA maintenance and degradation. Holmquist CE, He W, Meganck RM, Marzluff WF. RNA. 2022 Nov;28(11):1519-1533. doi: 10.1261/rna.079233.122. Epub 2022 Aug 30. PubMed
The histone methyltransferase SETD2 negatively regulates cell size. Molenaar TM, Malik M, Silva J, Liu NQ, Haarhuis JHI, Ambrosi C, Kwesi-Maliepaard EM, van Welsem T, Baubec T, Faller WJ, van Leeuwen F. J Cell Sci. 2022 Oct 1;135(19):jcs259856. doi: 10.1242/jcs.259856. Epub 2022 Oct 6. PubMed
1-deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells. Cordes T, Kuna RS, McGregor GH, Khare SV, Gengatharan J, Muthusamy T, Metallo CM. J Lipid Res. 2022 Sep 14:100281. doi: 10.1016/j.jlr.2022.100281. PubMed

Associated Plasmids

A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation. Drozdz MM, Doane AS, Alkallas R, Desman G, Bareja R, Reilly M, Bang J, Yusupova M, You J, Eraslan Z, Wang JZ, Verma A, Aguirre K, Kane E, Watson IR, Elemento O, Piskounova E, Merghoub T, Zippin JH. Cell Rep. 2022 Sep 27;40(13):111412. doi: 10.1016/j.celrep.2022.111412. PubMed
ETV6 Deficiency Unlocks ERG-Dependent Microsatellite Enhancers to Drive Aberrant Gene Activation in B-Lymphoblastic Leukemia. Kodgule R, Goldman JW, Monovich AC, Saari T, Aguilar AR, Hall CN, Rajesh N, Gupta J, Chu SA, Ye L, Gurumurthy A, Iyer A, Brown NA, Chiang MY, Cieslik MP, Ryan RJH. Blood Cancer Discov. 2023 Jan 6;4(1):34-53. doi: 10.1158/2643-3230.BCD-21-0224. PubMed
mRNA 5' terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay. van den Elzen AMG, Watson MJ, Thoreen CC. PLoS Genet. 2022 Nov 28;18(11):e1010532. doi: 10.1371/journal.pgen.1010532. eCollection 2022 Nov. PubMed
Deterministic Single Cell Encapsulation in Asymmetric Microenvironments to Direct Cell Polarity. Cho IS, Gupta P, Mostafazadeh N, Wong SW, Saichellappa S, Lenzini S, Peng Z, Shin JW. Adv Sci (Weinh). 2023 Jan;10(3):e2206014. doi: 10.1002/advs.202206014. Epub 2022 Dec 1. PubMed
CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy. Ishii S, Chino H, Ode KL, Kurikawa Y, Ueda HR, Matsuura A, Mizushima N, Itakura E. Mol Biol Cell. 2023 Apr 1;34(4):ar29. doi: 10.1091/mbc.E22-09-0432. Epub 2023 Feb 3. PubMed
Macrophages promote anti-androgen resistance in prostate cancer bone disease. Li XF, Selli C, Zhou HL, Cao J, Wu S, Ma RY, Lu Y, Zhang CB, Xun B, Lam AD, Pang XC, Fernando A, Zhang Z, Unciti-Broceta A, Carragher NO, Ramachandran P, Henderson NC, Sun LL, Hu HY, Li GB, Sawyers C, Qian BZ. J Exp Med. 2023 Apr 3;220(4):e20221007. doi: 10.1084/jem.20221007. Epub 2023 Feb 7. PubMed
TCF7L1 Regulates LGR5 Expression in Colorectal Cancer Cells. King CM, Marx OM, Ding W, Koltun WA, Yochum GS. Genes (Basel). 2023 Feb 14;14(2):481. doi: 10.3390/genes14020481. PubMed
CircSMARCA5 silencing impairs cell proliferation and invasion via the miR-17-3p-EGFR signaling in lung adenocarcinoma. Geng Q, Zhao H, Zhou Z, Chen X, Zhao H, Chen N, Li Y, Guo C, Yang A, Beer DG, Chen G. Life Sci. 2023 May 1;320:121560. doi: 10.1016/j.lfs.2023.121560. Epub 2023 Mar 7. PubMed
Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway. McCann JJ, Fleenor DE, Chen J, Lai CH, Bass TE, Kastan MB. Radiat Res. 2023 Apr 1;199(4):406-421. doi: 10.1667/RADE-22-00219.1. PubMed

Associated Plasmids

Thymidine nucleotide metabolism controls human telomere length. Mannherz W, Agarwal S. Nat Genet. 2023 Apr;55(4):568-580. doi: 10.1038/s41588-023-01339-5. Epub 2023 Mar 23. PubMed
Transcriptional activation of endogenous Oct4 via the CRISPR/dCas9 activator ameliorates Hutchinson-Gilford progeria syndrome in mice. Kim J, Hwang Y, Kim S, Chang Y, Kim Y, Kwon Y, Kim J. Aging Cell. 2023 Jun;22(6):e13825. doi: 10.1111/acel.13825. Epub 2023 Mar 25. PubMed
Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia. Yashar WM, Curtiss BM, Coleman DJ, VanCampen J, Kong G, Macaraeg J, Estabrook J, Demir E, Long N, Bottomly D, McWeeney SK, Tyner JW, Druker BJ, Maxson JE, Braun TP. Mol Cancer Res. 2023 Jul 5;21(7):631-647. doi: 10.1158/1541-7786.MCR-22-0745. PubMed
Protein supersaturation powers innate immune signaling. Rodriguez Gama A, Miller T, Lange JJ, Wu J, Song X, Venkatesan S, Unruh JR, Bradford D, Halfmann R. bioRxiv. 2023 Mar 21:2023.03.20.533581. doi: 10.1101/2023.03.20.533581. Preprint. PubMed
MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner. Xie G, Lee JE, Senft AD, Park YK, Jang Y, Chakraborty S, Thompson JJ, McKernan K, Liu C, Macfarlan TS, Rocha PP, Peng W, Ge K. Nat Genet. 2023 Apr 3. doi: 10.1038/s41588-023-01356-4. PubMed

Associated Plasmids

Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction. Spens AE, Sutliff NA, Bennett SR, Campbell AE, Tapscott SJ. Elife. 2023 Apr 24;12:e82057. doi: 10.7554/eLife.82057. PubMed
Adeno-associated virus vector system controlling capsid expression improves viral quantity and quality. Ohba K, Sehara Y, Enoki T, Mineno J, Ozawa K, Mizukami H. iScience. 2023 Mar 23;26(4):106487. doi: 10.1016/j.isci.2023.106487. eCollection 2023 Apr 21. PubMed
Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer. Wan L, Lin KT, Rahman MA, Ishigami Y, Wang Z, Jensen MA, Wilkinson JE, Park Y, Tuveson DA, Krainer AR. Cancer Discov. 2023 Jul 7;13(7):1678-1695. doi: 10.1158/2159-8290.CD-22-1013. PubMed
FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks. Mazouzi A, Moser SC, Abascal F, van den Broek B, Del Castillo Velasco-Herrera M, van der Heijden I, Hekkelman M, Drenth AP, van der Burg E, Kroese LJ, Jalink K, Adams DJ, Jonkers J, Brummelkamp TR. Sci Adv. 2023 Jun 2;9(22):eadf4409. doi: 10.1126/sciadv.adf4409. Epub 2023 May 31. PubMed
Human SAMD9 is a poxvirus-activatable anticodon nuclease inhibiting codon-specific protein synthesis. Zhang F, Ji Q, Chaturvedi J, Morales M, Mao Y, Meng X, Dong L, Deng J, Qian SB, Xiang Y. Sci Adv. 2023 Jun 9;9(23):eadh8502. doi: 10.1126/sciadv.adh8502. Epub 2023 Jun 7. PubMed
Heritable transcriptional defects from aberrations of nuclear architecture. Papathanasiou S, Mynhier NA, Liu S, Brunette G, Stokasimov E, Jacob E, Li L, Comenho C, van Steensel B, Buenrostro JD, Zhang CZ, Pellman D. Nature. 2023 Jul;619(7968):184-192. doi: 10.1038/s41586-023-06157-7. Epub 2023 Jun 7. PubMed

Associated Plasmids

CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling. Serwe G, Kachaner D, Gagnon J, Plutoni C, Lajoie D, Durame E, Sahmi M, Garrido D, Lefrancois M, Arseneault G, Saba-El-Leil MK, Meloche S, Emery G, Therrien M. Nat Commun. 2023 Jun 15;14(1):3560. doi: 10.1038/s41467-023-39281-z. PubMed
The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes. Djakovic L, Hennig T, Reinisch K, Milic A, Whisnant AW, Wolf K, Weiss E, Haas T, Grothey A, Jurges CS, Kluge M, Wolf E, Erhard F, Friedel CC, Dolken L. Nat Commun. 2023 Jul 31;14(1):4591. doi: 10.1038/s41467-023-40217-w. PubMed
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation. Chen PY, Huang BJ, Harris M, Boone C, Wang W, Carias H, Mesiona B, Mavrici D, Kohler AC, Bollag G, Zhang C, Zhang Y, Shannon K. JCI Insight. 2023 Sep 8;8(17):e168445. doi: 10.1172/jci.insight.168445. PubMed
DUX4-r exerts a neomorphic activity that depends on GTF2I in acute lymphoblastic leukemia. Campolungo D, Salome M, Biferali B, Tascini AS, Gabellini D. Sci Adv. 2023 Sep 15;9(37):eadi3771. doi: 10.1126/sciadv.adi3771. Epub 2023 Sep 15. PubMed
Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses. Espejo-Serrano C, Aitken C, Tan BF, May DG, Chrisopulos RJ, Roux KJ, Demmers JA, Mackintosh SG, Gribnau J, Bustos F, Gontan C, Findlay GM. Life Sci Alliance. 2024 Jan 10;7(3):e202302282. doi: 10.26508/lsa.202302282. Print 2024 Mar. PubMed
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD. Hruska-Plochan M, Wiersma VI, Betz KM, Mallona I, Ronchi S, Maniecka Z, Hock EM, Tantardini E, Laferriere F, Sahadevan S, Hoop V, Delvendahl I, Perez-Berlanga M, Gatta B, Panatta M, van der Bourg A, Bohaciakova D, Sharma P, De Vos L, Frontzek K, Aguzzi A, Lashley T, Robinson MD, Karayannis T, Mueller M, Hierlemann A, Polymenidou M. Nature. 2024 Feb;626(8001):1073-1083. doi: 10.1038/s41586-024-07042-7. Epub 2024 Feb 14. PubMed
Altered vacuole membrane protein 1 (VMP1) expression is associated with increased NLRP3 inflammasome activation and mitochondrial dysfunction. Zack SR, Venkatesan M, Nikolaienko R, Cook B, Melki R, Zima AV, Campbell EM. Inflamm Res. 2024 Apr;73(4):563-580. doi: 10.1007/s00011-024-01856-x. Epub 2024 Feb 27. PubMed
NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells. Saito Y, Yang Y, Saito M, Park CY, Funato K, Tabar V, Darnell RB. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2314695121. doi: 10.1073/pnas.2314695121. Epub 2024 Feb 28. PubMed
A Methodology for Specific Disruption of Microtubules in Dendritic Spines. Holland ED, Miller HL, Millette MM, Taylor RJ, Drucker GL, Dent EW. bioRxiv [Preprint]. 2024 Mar 4:2024.03.04.583370. doi: 10.1101/2024.03.04.583370. PubMed
Tumor Cell-Associated IL-1alpha Affects Breast Cancer Progression and Metastasis in Mice through Manipulation of the Tumor Immune Microenvironment. Krishnamohan M, Kaplanov I, Maudi-Boker S, Yousef M, Machluf-Katz N, Cohen I, Elkabets M, Titus J, Bersudsky M, Apte RN, Voronov E, Braiman A. Int J Mol Sci. 2024 Apr 2;25(7):3950. doi: 10.3390/ijms25073950. PubMed
SHIP inhibition mediates select TREM2-induced microglial functions. Ramakrishnan GS, Berry WL, Pacherille A, Kerr WG, Chisholm JD, Pedicone C, Humphrey MB. Mol Immunol. 2024 Jun;170:35-45. doi: 10.1016/j.molimm.2024.04.002. Epub 2024 Apr 12. PubMed
Dynamic control of gene expression by ISGF3 and IRF1 during IFNbeta and IFNgamma signaling. Ravi Sundar Jose Geetha A, Fischer K, Babadei O, Smesnik G, Vogt A, Platanitis E, Muller M, Farlik M, Decker T. EMBO J. 2024 Jun;43(11):2233-2263. doi: 10.1038/s44318-024-00092-7. Epub 2024 Apr 24. PubMed
p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol. Wrobel L, Hoffmann JL, Li X, Rubinsztein DC. Sci Adv. 2024 May 3;10(18):eadl6082. doi: 10.1126/sciadv.adl6082. Epub 2024 May 3. PubMed

Associated Plasmids

Herpes simplex encephalitis due to a mutation in an E3 ubiquitin ligase. Bibert S, Quinodoz M, Perriot S, Krebs FS, Jan M, Malta RC, Collinet E, Canales M, Mathias A, Faignart N, Roulet-Perez E, Meylan P, Brouillet R, Opota O, Lozano-Calderon L, Fellmann F, Guex N, Zoete V, Asner S, Rivolta C, Du Pasquier R, Bochud PY. Nat Commun. 2024 May 10;15(1):3969. doi: 10.1038/s41467-024-48287-0. PubMed
Targeted sequencing for hereditary breast and ovarian cancer in BRCA1/2-negative families reveals complex genetic architecture and phenocopies. Plowman JN, Matoy EJ, Uppala LV, Draves SB, Watson CJ, Sefranek BA, Stacey ML, Anderson SP, Belshan MA, Blue EE, Huff CD, Fu Y, Stessman HAF. HGG Adv. 2024 Jul 18;5(3):100306. doi: 10.1016/j.xhgg.2024.100306. Epub 2024 May 10. PubMed
Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase response. Ehle C, Iyer-Bierhoff A, Wu Y, Xing S, Kiehntopf M, Mosig AS, Godmann M, Heinzel T. Commun Biol. 2024 May 16;7(1):589. doi: 10.1038/s42003-024-06288-1. PubMed
Context dependent activity of p63-bound gene regulatory elements. McCann AA, Baniulyte G, Woodstock DL, Sammons MA. bioRxiv [Preprint]. 2024 May 12:2024.05.09.593326. doi: 10.1101/2024.05.09.593326. PubMed
TCF7L1 regulates colorectal cancer cell migration by repressing GAS1 expression. King CM, Ding W, Eshelman MA, Yochum GS. Sci Rep. 2024 May 30;14(1):12477. doi: 10.1038/s41598-024-63346-8. PubMed
Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling. Saunders N, Monel B, Cayet N, Archetti L, Moreno H, Jeanne A, Marguier A, Buchrieser J, Wai T, Schwartz O, Frechin M. Nat Commun. 2024 Jun 11;15(1):4996. doi: 10.1038/s41467-024-49260-7. PubMed

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