pCW57.1 Citations (154)
Originally described in: Root Lab pLEX and pLIX Gateway backbonesUnpublished
Articles Citing pCW57.1
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| Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. Vietri M, Schink KO, Campsteijn C, Wegner CS, Schultz SW, Christ L, Thoresen SB, Brech A, Raiborg C, Stenmark H. Nature. 2015 Jun 11;522(7555):231-5. doi: 10.1038/nature14408. Epub 2015 Jun 3. PubMed |
Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression.
Barger CJ, Zhang W, Hillman J, Stablewski AB, Higgins MJ, Vanderhyden BC, Odunsi K, Karpf AR.
Oncotarget. 2015 Jul 16.
PubMed
Associated Plasmids |
| Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers. Momcilovic M, McMickle R, Abt E, Seki A, Simko SA, Magyar C, Stout DB, Fishbein MC, Walser TC, Dubinett SM, Shackelford DB. Cancer Res. 2015 Nov 15;75(22):4910-22. doi: 10.1158/0008-5472.CAN-15-0797. PubMed |
| ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission. Christ L, Wenzel EM, Liestol K, Raiborg C, Campsteijn C, Stenmark H. J Cell Biol. 2016 Feb 29;212(5):499-513. doi: 10.1083/jcb.201507009. PubMed |
| PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Brown A, Patel S, Ward C, Lorenz A, Ortiz M, DuRoss A, Wieghardt F, Esch A, Otten EG, Heiser LM, Korolchuk VI, Sun C, Sarkar S, Sahay G. Sci Rep. 2016 Aug 30;6:31750. doi: 10.1038/srep31750. PubMed |
| Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell WK, Tan AC, Nemenoff R, Stenmark K, Jiang BH, Reyland ME, Heasley L, Hu CJ. Oncogenesis. 2017 Jan 16;6(1):e287. doi: 10.1038/oncsis.2016.89. PubMed |
Noncanonical function of DGCR8 controls mESC exit from pluripotency.
Cirera-Salinas D, Yu J, Bodak M, Ngondo RP, Herbert KM, Ciaudo C.
J Cell Biol. 2017 Jan 18. pii: jcb.201606073. doi: 10.1083/jcb.201606073.
PubMed
Associated Plasmids |
DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.
Shadle SC, Zhong JW, Campbell AE, Conerly ML, Jagannathan S, Wong CJ, Morello TD, van der Maarel SM, Tapscott SJ.
PLoS Genet. 2017 Mar 8;13(3):e1006658. doi: 10.1371/journal.pgen.1006658. eCollection 2017 Mar.
PubMed
Associated Plasmids |
| CRISPR-Cas9 system-driven site-specific selection pressure on Herpes simplex virus genomes. Li Z, Bi Y, Xiao H, Sun L, Ren Y, Li Y, Chen C, Cun W. Virus Res. 2017 Mar 6. pii: S0168-1702(16)30694-3. doi: 10.1016/j.virusres.2017.03.010. PubMed |
| Kaposi's sarcoma-associated herpesvirus ORF34 is essential for late gene expression and virus production. Nishimura M, Watanabe T, Yagi S, Yamanaka T, Fujimuro M. Sci Rep. 2017 Mar 23;7(1):329. doi: 10.1038/s41598-017-00401-7. PubMed |
| Dissection of ubiquitinated protein degradation by basal autophagy. Takayama K, Matsuura A, Itakura E. FEBS Lett. 2017 May;591(9):1199-1211. doi: 10.1002/1873-3468.12641. Epub 2017 Apr 18. PubMed |
Conservation and innovation in the DUX4-family gene network.
Whiddon JL, Langford AT, Wong CJ, Zhong JW, Tapscott SJ.
Nat Genet. 2017 Jun;49(6):935-940. doi: 10.1038/ng.3846. Epub 2017 May 1.
PubMed
Associated Plasmids |
| Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons. Hendrickson PG, Dorais JA, Grow EJ, Whiddon JL, Lim JW, Wike CL, Weaver BD, Pflueger C, Emery BR, Wilcox AL, Nix DA, Peterson CM, Tapscott SJ, Carrell DT, Cairns BR. Nat Genet. 2017 Jun;49(6):925-934. doi: 10.1038/ng.3844. Epub 2017 May 1. PubMed |
| INTERACTION OF THE MINERALOCORTICOID RECEPTOR WITH RACK1 AND ITS ROLE IN ALDOSTERONE SIGNALING. Kuppusamy M, Gomez-Sanchez EP, Beloate LN, Plonczynski M, Naray-Fejes-Toth A, Fejes-Toth G, Gomez-Sanchez CE. Endocrinology. 2017 May 2. doi: 10.1210/en.2017-00095. PubMed |
| Extracellular Interactions between Hepatitis C Virus and Secreted Apolipoprotein E. Li Z, Li Y, Bi Y, Zhang H, Yao Y, Li Q, Cun W, Dong S. J Virol. 2017 Jul 12;91(15). pii: e02227-16. doi: 10.1128/JVI.02227-16. Print 2017 Aug 1. PubMed |
The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity.
Feng Q, Jagannathan S, Bradley RK.
Mol Cell. 2017 Jul 20;67(2):239-251.e6. doi: 10.1016/j.molcel.2017.05.034. Epub 2017 Jun 29.
PubMed
Associated Plasmids |
| Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1. Feng YX, Jin DX, Sokol ES, Reinhardt F, Miller DH, Gupta PB. Nat Commun. 2017 Oct 20;8(1):1079. doi: 10.1038/s41467-017-01052-y. PubMed |
| The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, Gonzalez-Prieto R, Xiao Z, Verlaan-de Vries M, Vertegaal ACO. Nat Commun. 2017 Nov 27;8(1):1809. doi: 10.1038/s41467-017-01900-x. PubMed |
| Cockayne's Syndrome A and B Proteins Regulate Transcription Arrest after Genotoxic Stress by Promoting ATF3 Degradation. Epanchintsev A, Costanzo F, Rauschendorf MA, Caputo M, Ye T, Donnio LM, Proietti-de-Santis L, Coin F, Laugel V, Egly JM. Mol Cell. 2017 Dec 21;68(6):1054-1066.e6. doi: 10.1016/j.molcel.2017.11.009. Epub 2017 Dec 7. PubMed |
| KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulation. Campbell M, Watanabe T, Nakano K, Davis RR, Lyu Y, Tepper CG, Durbin-Johnson B, Fujimuro M, Izumiya Y. Nat Commun. 2018 Jan 4;9(1):49. doi: 10.1038/s41467-017-02089-9. PubMed |
| Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I Molecules. Moser SC, Voerman JSA, Buckley DL, Winter GE, Schliehe C. Front Immunol. 2018 Jan 8;8:1920. doi: 10.3389/fimmu.2017.01920. eCollection 2017. PubMed |
| Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma. Zeid R, Lawlor MA, Poon E, Reyes JM, Fulciniti M, Lopez MA, Scott TG, Nabet B, Erb MA, Winter GE, Jacobson Z, Polaski DR, Karlin KL, Hirsch RA, Munshi NP, Westbrook TF, Chesler L, Lin CY, Bradner JE. Nat Genet. 2018 Apr;50(4):515-523. doi: 10.1038/s41588-018-0044-9. Epub 2018 Jan 29. PubMed |
NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.
Campbell AE, Shadle SC, Jagannathan S, Lim JW, Resnick R, Tawil R, van der Maarel SM, Tapscott SJ.
Elife. 2018 Mar 13;7. pii: 31023. doi: 10.7554/eLife.31023.
PubMed
Associated Plasmids |
| DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins. Patel A, Yang P, Tinkham M, Pradhan M, Sun MA, Wang Y, Hoang D, Wolf G, Horton JR, Zhang X, Macfarlan T, Cheng X. Cell. 2018 Mar 22;173(1):221-233.e12. doi: 10.1016/j.cell.2018.02.058. Epub 2018 Mar 15. PubMed |
| Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth. Reichenbach B, Classon J, Aida T, Tanaka K, Genander M, Goritz C. EMBO J. 2018 May 2;37(9). pii: embj.201798280. doi: 10.15252/embj.201798280. Epub 2018 Apr 3. PubMed |
| A Raf-Competitive K-Ras Binder Can Fail to Functionally Antagonize Signaling. Kauke MJ, Tisdale AW, Kelly RL, Braun CJ, Hemann MT, Wittrup KD. Mol Cancer Ther. 2018 Aug;17(8):1773-1780. doi: 10.1158/1535-7163.MCT-17-0645. Epub 2018 May 2. PubMed |
| CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. Zimmermann M, Murina O, Reijns MAM, Agathanggelou A, Challis R, Tarnauskaite Z, Muir M, Fluteau A, Aregger M, McEwan A, Yuan W, Clarke M, Lambros MB, Paneesha S, Moss P, Chandrashekhar M, Angers S, Moffat J, Brunton VG, Hart T, de Bono J, Stankovic T, Jackson AP, Durocher D. Nature. 2018 Jul;559(7713):285-289. doi: 10.1038/s41586-018-0291-z. Epub 2018 Jul 4. PubMed |
| Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism. Studd JB, Yang M, Li Z, Vijayakrishnan J, Lu Y, Yeoh AE, Paulsson K, Houlston RS. Leukemia. 2019 Jan;33(1):1-14. doi: 10.1038/s41375-018-0184-z. Epub 2018 Jul 6. PubMed |
The shieldin complex mediates 53BP1-dependent DNA repair.
Noordermeer SM, Adam S, Setiaputra D, Barazas M, Pettitt SJ, Ling AK, Olivieri M, Alvarez-Quilon A, Moatti N, Zimmermann M, Annunziato S, Krastev DB, Song F, Brandsma I, Frankum J, Brough R, Sherker A, Landry S, Szilard RK, Munro MM, McEwan A, Goullet de Rugy T, Lin ZY, Hart T, Moffat J, Gingras AC, Martin A, van Attikum H, Jonkers J, Lord CJ, Rottenberg S, Durocher D.
Nature. 2018 Aug;560(7716):117-121. doi: 10.1038/s41586-018-0340-7. Epub 2018 Jul 18.
PubMed
Associated Plasmids |
| Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores. Janssen LME, Averink TV, Blomen VA, Brummelkamp TR, Medema RH, Raaijmakers JA. Curr Biol. 2018 Sep 10;28(17):2685-2696.e4. doi: 10.1016/j.cub.2018.06.026. Epub 2018 Aug 16. PubMed |
| A Single Point Mutation in the Rhinovirus 2B Protein Reduces the Requirement for Phosphatidylinositol 4-Kinase Class III Beta in Viral Replication. Roulin PS, Murer LP, Greber UF. J Virol. 2018 Nov 12;92(23). pii: JVI.01462-18. doi: 10.1128/JVI.01462-18. Print 2018 Dec 1. PubMed |
| Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4. Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, Quaranta E, Di Biagio D, Sigismondo G, Guzzardo V, Lejeune P, Haendler B, Krijgsveld J, Fassan M, Bicciato S, Cordenonsi M, Piccolo S. Nat Med. 2018 Oct;24(10):1599-1610. doi: 10.1038/s41591-018-0158-8. Epub 2018 Sep 17. PubMed |
| Src kinase phosphorylates Notch1 to inhibit MAML binding. LaFoya B, Munroe JA, Pu X, Albig AR. Sci Rep. 2018 Oct 19;8(1):15515. doi: 10.1038/s41598-018-33920-y. PubMed |
| INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. Elife. 2018 Oct 25;7. pii: 38539. doi: 10.7554/eLife.38539. PubMed |
| The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling. Massa F, Tammaro R, Prado MA, Cesana M, Lee BH, Finley D, Franco B, Morleo M. Hum Mol Genet. 2019 Mar 1;28(5):764-777. doi: 10.1093/hmg/ddy380. PubMed |
| The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S. Nature. 2018 Nov;563(7730):265-269. doi: 10.1038/s41586-018-0658-1. Epub 2018 Oct 31. PubMed |
| Subtype-specific regulatory network rewiring in acute myeloid leukemia. Assi SA, Imperato MR, Coleman DJL, Pickin A, Potluri S, Ptasinska A, Chin PS, Blair H, Cauchy P, James SR, Zacarias-Cabeza J, Gilding LN, Beggs A, Clokie S, Loke JC, Jenkin P, Uddin A, Delwel R, Richards SJ, Raghavan M, Griffiths MJ, Heidenreich O, Cockerill PN, Bonifer C. Nat Genet. 2019 Jan;51(1):151-162. doi: 10.1038/s41588-018-0270-1. Epub 2018 Nov 12. PubMed |
| Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression. Mowery CT, Reyes JM, Cabal-Hierro L, Higby KJ, Karlin KL, Wang JH, Kimmerling RJ, Cejas P, Lim K, Li H, Furusawa T, Long HW, Pellman D, Chapuy B, Bustin M, Manalis SR, Westbrook TF, Lin CY, Lane AA. Cell Rep. 2018 Nov 13;25(7):1898-1911.e5. doi: 10.1016/j.celrep.2018.10.061. PubMed |
| S-Palmitoylation Sorts Membrane Cargo for Anterograde Transport in the Golgi. Ernst AM, Syed SA, Zaki O, Bottanelli F, Zheng H, Hacke M, Xi Z, Rivera-Molina F, Graham M, Rebane AA, Bjorkholm P, Baddeley D, Toomre D, Pincet F, Rothman JE. Dev Cell. 2018 Nov 19;47(4):479-493.e7. doi: 10.1016/j.devcel.2018.10.024. PubMed |
| Nucleus-localized adiponectin is survival gatekeeper through miR-214-mediated AIFM2 regulation. Cho J, Teshigawara R, Kameda M, Yamaguchi S, Tada T. Genes Cells. 2019 Feb;24(2):126-138. doi: 10.1111/gtc.12658. Epub 2019 Jan 2. PubMed |
| Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma. Edginton-White B, Cauchy P, Assi SA, Hartmann S, Riggs AG, Mathas S, Cockerill PN, Bonifer C. Leukemia. 2018 Dec 13. pii: 10.1038/s41375-018-0311-x. doi: 10.1038/s41375-018-0311-x. PubMed |
| TRB1 negatively regulates gluconeogenesis by suppressing the transcriptional activity of FOXO1. Tsuzuki K, Itoh Y, Inoue Y, Hayashi H. FEBS Lett. 2019 Feb;593(3):369-380. doi: 10.1002/1873-3468.13314. Epub 2019 Jan 8. PubMed |
| A comparison of resveratrol and other polyphenolic compounds on Notch activation and endothelial cell activity. LaFoya B, Munroe JA, Albig AR. PLoS One. 2019 Jan 17;14(1):e0210607. doi: 10.1371/journal.pone.0210607. eCollection 2019. PubMed |
| Follicular lymphoma-associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and mTOR. Wang F, Gatica D, Ying ZX, Peterson LF, Kim P, Bernard D, Saiya-Cork K, Wang S, Kaminski MS, Chang AE, Phillips T, Klionsky DJ, Malek SN. J Clin Invest. 2019 Mar 4;130:1626-1640. doi: 10.1172/JCI98288. eCollection 2019 Mar 4. PubMed |
MDM2 and MDM4 are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors.
Howard TP, Arnoff TE, Song MR, Giacomelli AO, Wang X, Hong AL, Dharia NV, Wang S, Vazquez F, Pham MT, Morgan AM, Wachter F, Bird GH, Kugener G, Oberlick EM, Rees MG, Tiv HL, Hwang JH, Walsh KH, Cook A, Krill-Burger JM, Tsherniak A, Gokhale PC, Park PJ, Stegmaier K, Walensky LD, Hahn WC, Roberts CWM.
Cancer Res. 2019 Feb 12. pii: 0008-5472.CAN-18-3066. doi: 10.1158/0008-5472.CAN-18-3066.
PubMed
Associated Plasmids |
Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer.
Barger CJ, Branick C, Chee L, Karpf AR.
Cancers (Basel). 2019 Feb 21;11(2). pii: cancers11020251. doi: 10.3390/cancers11020251.
PubMed
Associated Plasmids |
| Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding. Li S, Chen K, Zhang Y, Barnes SD, Jaichander P, Zheng Y, Hassan M, Malladi VS, Skapek SX, Xu L, Bassel-Duby R, Olson EN, Liu N. Genes Dev. 2019 Jun 1;33(11-12):626-640. doi: 10.1101/gad.324467.119. Epub 2019 Apr 11. PubMed |
| OVOL2 induces mesenchymal-to-epithelial transition in fibroblasts and enhances cell-state reprogramming towards epithelial lineages. Watanabe K, Liu Y, Noguchi S, Murray M, Chang JC, Kishima M, Nishimura H, Hashimoto K, Minoda A, Suzuki H. Sci Rep. 2019 Apr 24;9(1):6490. doi: 10.1038/s41598-019-43021-z. PubMed |
| Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer. Parolia A, Cieslik M, Chu SC, Xiao L, Ouchi T, Zhang Y, Wang X, Vats P, Cao X, Pitchiaya S, Su F, Wang R, Feng FY, Wu YM, Lonigro RJ, Robinson DR, Chinnaiyan AM. Nature. 2019 Jul;571(7765):413-418. doi: 10.1038/s41586-019-1347-4. Epub 2019 Jun 26. PubMed |
| A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription. Platanitis E, Demiroz D, Schneller A, Fischer K, Capelle C, Hartl M, Gossenreiter T, Muller M, Novatchkova M, Decker T. Nat Commun. 2019 Jul 2;10(1):2921. doi: 10.1038/s41467-019-10970-y. PubMed |
| How to Choose the Right Inducible Gene Expression System for Mammalian Studies? Kallunki T, Barisic M, Jaattela M, Liu B. Cells. 2019 Jul 30;8(8). pii: cells8080796. doi: 10.3390/cells8080796. PubMed |
Identification of a factor controlling lysosomal homeostasis using a novel lysosomal trafficking probe.
Ishii S, Matsuura A, Itakura E.
Sci Rep. 2019 Aug 12;9(1):11635. doi: 10.1038/s41598-019-48131-2.
PubMed
Associated Plasmids |
Control of homologous recombination by the HROB-MCM8-MCM9 pathway.
Hustedt N, Saito Y, Zimmermann M, Alvarez-Quilon A, Setiaputra D, Adam S, McEwan A, Yuan JY, Olivieri M, Zhao Y, Kanemaki MT, Jurisicova A, Durocher D.
Genes Dev. 2019 Oct 1;33(19-20):1397-1415. doi: 10.1101/gad.329508.119. Epub 2019 Aug 29.
PubMed
Associated Plasmids |
| A consensus set of genetic vulnerabilities to ATR inhibition. Hustedt N, Alvarez-Quilon A, McEwan A, Yuan JY, Cho T, Koob L, Hart T, Durocher D. Open Biol. 2019 Sep 27;9(9):190156. doi: 10.1098/rsob.190156. Epub 2019 Sep 11. PubMed |
| DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Samir P, Kesavardhana S, Patmore DM, Gingras S, Malireddi RKS, Karki R, Guy CS, Briard B, Place DE, Bhattacharya A, Sharma BR, Nourse A, King SV, Pitre A, Burton AR, Pelletier S, Gilbertson RJ, Kanneganti TD. Nature. 2019 Sep;573(7775):590-594. doi: 10.1038/s41586-019-1551-2. Epub 2019 Sep 11. PubMed |
| UL26 Attenuates IKKbeta-Mediated Induction of Interferon-Stimulated Gene (ISG) Expression and Enhanced Protein ISGylation during Human Cytomegalovirus Infection. Goodwin CM, Schafer X, Munger J. J Virol. 2019 Nov 13;93(23). pii: JVI.01052-19. doi: 10.1128/JVI.01052-19. Print 2019 Dec 1. PubMed |
| BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis. Huang K, O'Neill KL, Li J, Zhou W, Han N, Pang X, Wu W, Struble L, Borgstahl G, Liu Z, Zhang L, Luo X. Cell Res. 2019 Nov;29(11):942-952. doi: 10.1038/s41422-019-0231-y. Epub 2019 Sep 24. PubMed |
| Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massague J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26. PubMed |
| MX 2 is a novel regulator of cell cycle in melanoma cells. Juraleviciute M, Pozniak J, Nsengimana J, Harland M, Randerson-Moor J, Wernhoff P, Bassarova A, Oy GF, Troen G, Florenes VA, Bishop DT, Herlyn M, Newton-Bishop J, Slipicevic A. Pigment Cell Melanoma Res. 2019 Oct 29. doi: 10.1111/pcmr.12837. PubMed |
| Reprogramming of DNA methylation at NEUROD2-bound sequences during cortical neuron differentiation. Hahn MA, Jin SG, Li AX, Liu J, Huang Z, Wu X, Kim BW, Johnson J, Bilbao AV, Tao S, Yim JA, Fong Y, Goebbels S, Schwab MH, Lu Q, Pfeifer GP. Sci Adv. 2019 Oct 23;5(10):eaax0080. doi: 10.1126/sciadv.aax0080. eCollection 2019 Oct. PubMed |
| DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression. Resnick R, Wong CJ, Hamm DC, Bennett SR, Skene PJ, Hake SB, Henikoff S, van der Maarel SM, Tapscott SJ. Cell Rep. 2019 Nov 12;29(7):1812-1820.e5. doi: 10.1016/j.celrep.2019.10.025. PubMed |
| Enhanced lysosomal degradation maintains the quiescent state of neural stem cells. Kobayashi T, Piao W, Takamura T, Kori H, Miyachi H, Kitano S, Iwamoto Y, Yamada M, Imayoshi I, Shioda S, Ballabio A, Kageyama R. Nat Commun. 2019 Nov 29;10(1):5446. doi: 10.1038/s41467-019-13203-4. PubMed |
The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex.
Bauer M, Flatt JW, Seiler D, Cardel B, Emmenlauer M, Boucke K, Suomalainen M, Hemmi S, Greber UF.
Cell Rep. 2019 Dec 17;29(12):3785-3795.e8. doi: 10.1016/j.celrep.2019.11.064.
PubMed
Associated Plasmids |
| Interferon mediated neuroinflammation in polyglutamine disease is not caused by RNA toxicity. Bhambri A, Pinto A, Pillai B. Cell Death Dis. 2020 Jan 2;11(1):3. doi: 10.1038/s41419-019-2193-x. PubMed |
| Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence. Miyajima C, Kawarada Y, Inoue Y, Suzuki C, Mitamura K, Morishita D, Ohoka N, Imamura T, Hayashi H. Cells. 2020 Jan 9;9(1). pii: cells9010171. doi: 10.3390/cells9010171. PubMed |
| Codon optimization is an essential parameter for the efficient allotopic expression of mtDNA genes. Lewis CJ, Dixit B, Batiuk E, Hall CJ, O'Connor MS, Boominathan A. Redox Biol. 2020 Feb;30:101429. doi: 10.1016/j.redox.2020.101429. Epub 2020 Jan 11. PubMed |
| Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2. Morita K, He S, Nowak RP, Wang J, Zimmerman MW, Fu C, Durbin AD, Martel MW, Prutsch N, Gray NS, Fischer ES, Look AT. Cell. 2020 Apr 30;181(3):702-715.e20. doi: 10.1016/j.cell.2020.03.051. Epub 2020 Apr 20. PubMed |
| HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis. Bai G, Kermi C, Stoy H, Schiltz CJ, Bacal J, Zaino AM, Hadden MK, Eichman BF, Lopes M, Cimprich KA. Mol Cell. 2020 Jun 18;78(6):1237-1251.e7. doi: 10.1016/j.molcel.2020.04.031. Epub 2020 May 21. PubMed |
| Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Alvarez-Quilon A, Wojtaszek JL, Mathieu MC, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Munoz IM, Grazzini E, Young JTF, Rouse J, Zinda M, Williams RS, Durocher D. Mol Cell. 2020 Jun 18;78(6):1152-1165.e8. doi: 10.1016/j.molcel.2020.05.021. Epub 2020 Jun 8. PubMed |
| Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation. Xie L, Hu WY, Hu DP, Shi G, Li Y, Yang J, Prins GS. Environ Health Perspect. 2020 Jun;128(6):67008. doi: 10.1289/EHP6471. Epub 2020 Jun 11. PubMed |
| Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase. Abdisalaam S, Bhattacharya S, Mukherjee S, Sinha D, Srinivasan K, Zhu M, Akbay EA, Sadek HA, Shay JW, Asaithamby A. J Biol Chem. 2020 Aug 7;295(32):11144-11160. doi: 10.1074/jbc.RA120.012962. Epub 2020 Jun 15. PubMed |
| FGFR1 Is Critical for RBL2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer. Kim KB, Kim Y, Rivard CJ, Kim DW, Park KS. Cancer Res. 2020 Nov 15;80(22):5051-5062. doi: 10.1158/0008-5472.CAN-20-1453. Epub 2020 Sep 24. PubMed |
| SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling. Fedele C, Li S, Teng KW, Foster CJR, Peng D, Ran H, Mita P, Geer MJ, Hattori T, Koide A, Wang Y, Tang KH, Leinwand J, Wang W, Diskin B, Deng J, Chen T, Dolgalev I, Ozerdem U, Miller G, Koide S, Wong KK, Neel BG. J Exp Med. 2021 Jan 4;218(1). pii: 211451. doi: 10.1084/jem.20201414. PubMed |
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| The Endoplasmic Reticulum Stress Sensor IRE1alpha Regulates the UV DNA Repair Response through the Control of Intracellular Calcium Homeostasis. Son J, Mogre S, Chalmers FE, Ibinson J, Worrell S, Glick AB. J Invest Dermatol. 2021 Nov 20. pii: S0022-202X(21)02508-2. doi: 10.1016/j.jid.2021.11.010. PubMed |
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Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.
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| ROR activation by Nobiletin enhances antitumor efficacy via suppression of IkappaB/NF-kappaB signaling in triple-negative breast cancer. Kim E, Kim YJ, Ji Z, Kang JM, Wirianto M, Paudel KR, Smith JA, Ono K, Kim JA, Eckel-Mahan K, Zhou X, Lee HK, Yoo JY, Yoo SH, Chen Z. Cell Death Dis. 2022 Apr 19;13(4):374. doi: 10.1038/s41419-022-04826-5. PubMed |
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| A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation. Drozdz MM, Doane AS, Alkallas R, Desman G, Bareja R, Reilly M, Bang J, Yusupova M, You J, Eraslan Z, Wang JZ, Verma A, Aguirre K, Kane E, Watson IR, Elemento O, Piskounova E, Merghoub T, Zippin JH. Cell Rep. 2022 Sep 27;40(13):111412. doi: 10.1016/j.celrep.2022.111412. PubMed |
| ETV6 Deficiency Unlocks ERG-Dependent Microsatellite Enhancers to Drive Aberrant Gene Activation in B-Lymphoblastic Leukemia. Kodgule R, Goldman JW, Monovich AC, Saari T, Aguilar AR, Hall CN, Rajesh N, Gupta J, Chu SA, Ye L, Gurumurthy A, Iyer A, Brown NA, Chiang MY, Cieslik MP, Ryan RJH. Blood Cancer Discov. 2023 Jan 6;4(1):34-53. doi: 10.1158/2643-3230.BCD-21-0224. PubMed |
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Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway.
McCann JJ, Fleenor DE, Chen J, Lai CH, Bass TE, Kastan MB.
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| Thymidine nucleotide metabolism controls human telomere length. Mannherz W, Agarwal S. Nat Genet. 2023 Apr;55(4):568-580. doi: 10.1038/s41588-023-01339-5. Epub 2023 Mar 23. PubMed |
| Transcriptional activation of endogenous Oct4 via the CRISPR/dCas9 activator ameliorates Hutchinson-Gilford progeria syndrome in mice. Kim J, Hwang Y, Kim S, Chang Y, Kim Y, Kwon Y, Kim J. Aging Cell. 2023 Jun;22(6):e13825. doi: 10.1111/acel.13825. Epub 2023 Mar 25. PubMed |
| Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia. Yashar WM, Curtiss BM, Coleman DJ, VanCampen J, Kong G, Macaraeg J, Estabrook J, Demir E, Long N, Bottomly D, McWeeney SK, Tyner JW, Druker BJ, Maxson JE, Braun TP. Mol Cancer Res. 2023 Jul 5;21(7):631-647. doi: 10.1158/1541-7786.MCR-22-0745. PubMed |
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MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.
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| Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction. Spens AE, Sutliff NA, Bennett SR, Campbell AE, Tapscott SJ. Elife. 2023 Apr 24;12:e82057. doi: 10.7554/eLife.82057. PubMed |
| Adeno-associated virus vector system controlling capsid expression improves viral quantity and quality. Ohba K, Sehara Y, Enoki T, Mineno J, Ozawa K, Mizukami H. iScience. 2023 Mar 23;26(4):106487. doi: 10.1016/j.isci.2023.106487. eCollection 2023 Apr 21. PubMed |
| Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer. Wan L, Lin KT, Rahman MA, Ishigami Y, Wang Z, Jensen MA, Wilkinson JE, Park Y, Tuveson DA, Krainer AR. Cancer Discov. 2023 Jul 7;13(7):1678-1695. doi: 10.1158/2159-8290.CD-22-1013. PubMed |
| FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks. Mazouzi A, Moser SC, Abascal F, van den Broek B, Del Castillo Velasco-Herrera M, van der Heijden I, Hekkelman M, Drenth AP, van der Burg E, Kroese LJ, Jalink K, Adams DJ, Jonkers J, Brummelkamp TR. Sci Adv. 2023 Jun 2;9(22):eadf4409. doi: 10.1126/sciadv.adf4409. Epub 2023 May 31. PubMed |
| Human SAMD9 is a poxvirus-activatable anticodon nuclease inhibiting codon-specific protein synthesis. Zhang F, Ji Q, Chaturvedi J, Morales M, Mao Y, Meng X, Dong L, Deng J, Qian SB, Xiang Y. Sci Adv. 2023 Jun 9;9(23):eadh8502. doi: 10.1126/sciadv.adh8502. Epub 2023 Jun 7. PubMed |
Heritable transcriptional defects from aberrations of nuclear architecture.
Papathanasiou S, Mynhier NA, Liu S, Brunette G, Stokasimov E, Jacob E, Li L, Comenho C, van Steensel B, Buenrostro JD, Zhang CZ, Pellman D.
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| CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling. Serwe G, Kachaner D, Gagnon J, Plutoni C, Lajoie D, Durame E, Sahmi M, Garrido D, Lefrancois M, Arseneault G, Saba-El-Leil MK, Meloche S, Emery G, Therrien M. Nat Commun. 2023 Jun 15;14(1):3560. doi: 10.1038/s41467-023-39281-z. PubMed |
| The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes. Djakovic L, Hennig T, Reinisch K, Milic A, Whisnant AW, Wolf K, Weiss E, Haas T, Grothey A, Jurges CS, Kluge M, Wolf E, Erhard F, Friedel CC, Dolken L. Nat Commun. 2023 Jul 31;14(1):4591. doi: 10.1038/s41467-023-40217-w. PubMed |
| Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation. Chen PY, Huang BJ, Harris M, Boone C, Wang W, Carias H, Mesiona B, Mavrici D, Kohler AC, Bollag G, Zhang C, Zhang Y, Shannon K. JCI Insight. 2023 Sep 8;8(17):e168445. doi: 10.1172/jci.insight.168445. PubMed |
| DUX4-r exerts a neomorphic activity that depends on GTF2I in acute lymphoblastic leukemia. Campolungo D, Salome M, Biferali B, Tascini AS, Gabellini D. Sci Adv. 2023 Sep 15;9(37):eadi3771. doi: 10.1126/sciadv.adi3771. Epub 2023 Sep 15. PubMed |
| Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses. Espejo-Serrano C, Aitken C, Tan BF, May DG, Chrisopulos RJ, Roux KJ, Demmers JA, Mackintosh SG, Gribnau J, Bustos F, Gontan C, Findlay GM. Life Sci Alliance. 2024 Jan 10;7(3):e202302282. doi: 10.26508/lsa.202302282. Print 2024 Mar. PubMed |
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